Abstract: The invention is directed to methods of removing adventitious virus from cells and cell lines and virus-free cells and cell lines obtainable by such methods.

Abstract: Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction and use, are provided. The vectors have a structure, or are capable of rapidly adopting a structure, which involves intrastrand base pairing of at least one region in a heterologous sequence.

Abstract: Methods and systems for determining and comparing physician adherence to guidelines are disclosed. The methods can comprise receiving patient data, scoring criteria, determining domain and overall scores, and comparing said scores. The methods can comprise receiving patient data, scoring criteria, determining overall scores, and comparing said scores. The methods provide a list of criteria and a scoring algorithm for deriving adherence scores useful for evaluating physician care. The methods allow for the comparison of standards of care between physicians, facilities, and between classes of patients.