Abstract: Among other things, the present disclosure provides oligonucleotides targeting SARM1 and compositions thereof. In some embodiments, the present disclosure provides methods for preventing or treating various conditions, disorders or diseases.

Abstract: Among other things, the present disclosure provides oligonucleotides targeting calpain-2 and compositions thereof. In some embodiments, the present disclosure provides methods for preventing or treating various conditions, disorders or diseases.

Abstract: Described are systems and methods that enable secure real time communication (“RTC”) sessions that may be used, for example, for editing and movie production. Client devices may interact with an RTC management system to obtain color calibration information so that the color presented on the different client devices is consistent with each other and corresponds to the intended color of the video for which collaboration is to be performed. In addition, on-going multifactor authentication may be performed for each client device of an RTC session during the RTC session. Still further, to improve the quality of the exchanged video information and to reduce transmission requirements, in response to detection of events, such as a pause event, a high resolution image of a paused video may be generated and sent for presentation on the display of each client device, instead of continuing to stream a paused video.

Abstract: Described herein are methods for using compounds that activate pyruvate kinase.

Abstract: A system and method for retrofitting a vehicle with a UV light air sterilization system is installed by forming one or more openings in the ventilation system and sealingly securing UV LED light source units in each of the openings in an air-tight connection so that air does not escape the ventilation system through said openings. The UV lights are connected electrically with the electrical system of the vehicle and that illuminates them at a frequency and intensity of UVC light with germicidal or bactericidal effect on air in their location. A switch or relay switches the electrical current on and supplies electrical current to the UV light sources when manually activated by a user of the vehicle, responsive to electrical power being supplied to the fan device, or responsive to a sensor detecting airflow in the ventilation system.

Abstract: Described are systems and methods that enable secure real time communication (“RTC”) sessions that may be used, for example, for editing and movie production. Client devices may interact with an RTC management system to collaborate on different files retained on the different client devices, without the files having to be uploaded from the client device on which it is stored. In addition, on-going multifactor authentication may be performed for each client device of an RTC session during the RTC session and/or video authentication may be used to grant access into an RTC session. Still further, to improve the quality of the exchanged video information and to reduce transmission requirements, in response to detection of events, such as a pause event, a high resolution image of a paused video may be generated and sent for presentation on the display of each client device, instead of continuing to stream a paused video.

Abstract: Described are systems and methods that enable secure real time communication (“RTC”) sessions that may be used, for example, for editing and movie production. Client devices may interact with an RTC management system to obtain color calibration information so that the color presented on the different client devices is consistent with each other and corresponds to the intended color of the video for which collaboration is to be performed. In addition, on-going multifactor authentication may be performed for each client device of an RTC session during the RTC session. Still further, to improve the quality of the exchanged video information and to reduce transmission requirements, in response to detection of events, such as a pause event, a high resolution image of a paused video may be generated and sent for presentation on the display of each client device, instead of continuing to stream a paused video.

Abstract: A robotic system for treating the skin of a patient has a robotic arm with several degrees of freedom supporting a navigation unit at an end distal to its base. The navigation unit holds a medical instrument, such as a scalpel, a microneedle tool, a plasma skin treatment device, or other medical instrument. The navigation unit has sensors that sense the distance and angle of attitude of the tool relative to the patient. A control system provides for a programmed movement of the medical instrument through a series of movements on or near the skin of the patient. Relying on the sensors in the navigational unit, the control system navigation maintains the medical instrument at a predetermined operating distance from and at a predetermined angle to the skin of the patient as the instrument is moved through the procedure, whether controlled robotically and autonomously or manually.

Abstract: Described are systems and methods that enable secure real time communication (“RTC”) sessions that may be used, for example, for editing and movie production. Client devices may interact with an RTC management system to obtain color calibration information so that the color presented on the different client devices is consistent with each other and corresponds to the intended color of the video for which collaboration is to be performed. In addition, on-going multifactor authentication may be performed for each client device of an RTC session during the RTC session. Still further, to improve the quality of the exchanged video information and to reduce transmission requirements, in response to detection of events, such as a pause event, a high resolution image of a paused video may be generated and sent for presentation on the display of each client device, instead of continuing to stream a paused video.

Abstract: A charter reservation system which takes place on a server computer for creating charter airline reservations. User input is received for reserving one or more seats on a charter airline, in which the user is financially responsible for all the available seats on the charter airline. Thereafter, the user input is sent to a plurality of private charter airlines without the use on an intermediate broker. Once the user input is sent to the airlines, users are sent offers received from private charter airlines. The system receives user input regarding one of the offers received to reserve a customized charter shuttle with routes and times prescribed by the user input. If any available seats remain, the system receives user input to offer the seats to registered users on the charter reservation system. Thereafter, a credit is provided to the user for each available seat sold to other registered users.

Abstract: The present invention relates to pharmaceutical comprising multimeric-multiepitope influenza polypeptides, to processes for their production and to their use as immunizing subjects against influenza. In particular, the invention relates to stable aqueous microparticulate suspensions and solid compositions comprising a multimeric multiepitope polypeptide.

Abstract: Pharmaceutical suspensions of multimeric-multiepitope influenza polypeptides, processes for their production and their use as immunizing subjects against influenza. In particular, stable aqueous microparticulate suspensions of a multimeric multiepitope polypeptide are disclosed.

Abstract: A method is described that involves creating a private key and a public key cryptographic key pair, generating a unique and random identifier for a voter's vote and accepting an election vote from said voter. The vote and identifier are electronically signed with the private key to create a digital signature. The vote and identifier are provided in a human readable format to the voter.

Abstract: Pharmaceutical suspensions of multimeric-multiepitope influenza polypeptides, processes for their production and their use as immunizing subjects against influenza. In particular, stable aqueous microparticulate suspensions of a multimeric multiepitope polypeptide are disclosed.

Abstract: A method is described that involves creating a private key and a public key cryptographic key pair, generating a unique and random identifier for a voter's vote and accepting an election vote from said voter. The vote and identifier are electronically signed with the private key to create a digital signature. The vote and identifier are provided in a human readable format to the voter.

Abstract: The invention provides for a modified roulette table layout comprising at least one additional betting position, wherein the additional betting position provides a wager equivalent to an existing betting position.

Abstract: A method is described that involves creating a private key and a public key cryptographic key pair, generating a unique and random identifier for a voter's vote and accepting an election vote from said voter. The vote and identifier are electronically signed with the private key to create a digital signature. The vote and identifier are provided in a human readable format to the voter.