Patents by Inventor Barry E. Rothenberg
Barry E. Rothenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884910Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: GrantFiled: August 3, 2023Date of Patent: January 30, 2024Assignee: Embrient, Inc.Inventors: Kyong-su Son, Royal Q. Le, Barry E. Rothenberg
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Publication number: 20230374437Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: ApplicationFiled: August 3, 2023Publication date: November 23, 2023Applicant: Embrient, Inc.Inventors: Kyong-su Son, Royal Q. Le, Barry E. Rothenberg
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Patent number: 11780871Abstract: Compositions and methods are presented that reduce the risk for ARDS and/or need for ventilation in a patient diagnosed with a coronavirus, and particularly SARS-CoV-2 virus, a SARS virus, or a MERS virus. In preferred aspects, HMW-HA is administered to the lung before onset of ARDS and/or cytokine storm. Additionally, NAD+ may be co-administered or prophylactically administered where NAD+levels are low.Type: GrantFiled: March 29, 2021Date of Patent: October 10, 2023Assignee: BILLUPS-ROTHENBERG, INC.Inventor: Barry E. Rothenberg
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Publication number: 20230242861Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: ApplicationFiled: March 28, 2023Publication date: August 3, 2023Applicant: Embrient, Inc.Inventors: Royal Q. Le, Barry E. Rothenberg, Kyong-su Son
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Patent number: 11634681Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: GrantFiled: May 16, 2022Date of Patent: April 25, 2023Assignee: EMBRIENT, INC.Inventors: Royal Q. Le, Barry E. Rothenberg, Kyong-su Son
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Patent number: 11591562Abstract: Provided herein are systems for continuously measuring oxygen and carbon dioxide gas levels inside a cell culture incubator, comprising an oxygen sensor that uses LED based fluorescence technology to determine the amount of oxygen in the surrounding atmosphere, a carbon dioxide sensor that uses LED based Non-dispersive Infra-Red (NDIR) technology to determine the amount of carbon dioxide in the surrounding atmosphere, and electronics to wirelessly monitor the output from the oxygen sensor and carbon dioxide sensor. Most preferably, the system can be placed inside a cell culture incubator, and sensor readings are pre-compensated for temperature, pressure, and humidity. Also provided herein are methods of using the same.Type: GrantFiled: December 18, 2019Date of Patent: February 28, 2023Assignee: BILLUPS-ROTHENBERG, INC.Inventors: Royal Q. Le, Kyong Son, Barry E. Rothenberg
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Patent number: 11471840Abstract: Provided herein are gas mixing systems, comprising a gas inlet for receiving two or more gases and a mixing chamber with a static mixer for mixing the gases. Preferred mixing chambers further comprise a reduced pressure compartment downstream of the static mixer that is in fluid communication with the gas inlet. A gas outlet is in fluid communication with the mixing chamber, and one or more sensors are coupled to the reduced pressure compartment and are configured to continuously sense various parameters such as barometric pressure and the percentage of oxygen in the gas mixture moving through the mixing device. Most typically, the readings of the sensor are pre-compensated for temperature, pressure, and humidity. Also provided herein are methods for using the same.Type: GrantFiled: December 18, 2019Date of Patent: October 18, 2022Assignee: BILLUPS-ROTHENBERG, INC.Inventors: Royal Q. Le, Kyong Son, Barry E. Rothenberg
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Publication number: 20220275322Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: ApplicationFiled: May 16, 2022Publication date: September 1, 2022Applicant: Embrient, Inc.Inventors: Royal Q. Le, Barry E. Rothenberg, Kyong-su Son
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Patent number: 11365385Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: GrantFiled: November 10, 2021Date of Patent: June 21, 2022Assignee: EMBRIENT, INC.Inventors: Royal Q. Le, Barry E. Rothenberg, Kyong-su Son
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Publication number: 20220089998Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: ApplicationFiled: November 10, 2021Publication date: March 24, 2022Inventors: Royal Q. Le, Barry E. Rothenberg, Kyong-su Son
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Patent number: 11203737Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: GrantFiled: June 24, 2021Date of Patent: December 21, 2021Inventors: Royal Q. Le, Barry E. Rothenberg, Kyong-Su Son
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Publication number: 20210324322Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: ApplicationFiled: June 24, 2021Publication date: October 21, 2021Inventors: Royal Q. Le, Barry E. Rothenberg, Kyong-su Son
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Patent number: 11072773Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: GrantFiled: November 24, 2020Date of Patent: July 27, 2021Inventors: Barry E. Rothenberg, Kyong-su Son, Royal Q Le
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Publication number: 20210079336Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: ApplicationFiled: November 24, 2020Publication date: March 18, 2021Inventors: Barry E. Rothenberg, Kyong-su Son, Royal Q. Le
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Patent number: 10900010Abstract: An incubator for cell and tissue culture under controlled atmospheric conditions has a primary air flow control device that forms a primary, preferably laminar flow, air veil across an opening that allows access to the cells or tissue cultures disposed within the incubator. Preferably, most if not all of the air in the primary (laminar flow) air veil is recirculated, and a secondary air flow control device is used that forms a secondary, preferably laminar flow, air veil between the primary (laminar flow) air veil and a user of the incubator.Type: GrantFiled: September 3, 2020Date of Patent: January 26, 2021Inventors: Barry E. Rothenberg, Kyong-su Son, Royal Q Le
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Publication number: 20200190459Abstract: Provided herein are systems for continuously measuring oxygen and carbon dioxide gas levels inside a cell culture incubator, comprising an oxygen sensor that uses LED based fluorescence technology to determine the amount of oxygen in the surrounding atmosphere, a carbon dioxide sensor that uses LED based Non-dispersive Infra-Red (NDIR) technology to determine the amount of carbon dioxide in the surrounding atmosphere, and electronics to wirelessly monitor the output from the oxygen sensor and carbon dioxide sensor. Most preferably, the system can be placed inside a cell culture incubator, and sensor readings are pre-compensated for temperature, pressure, and humidity. Also provided herein are methods of using the same.Type: ApplicationFiled: December 18, 2019Publication date: June 18, 2020Inventors: Royal Q. Le, Kyong Son, Barry E. Rothenberg
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Publication number: 20200188865Abstract: Provided herein are gas mixing systems, comprising a gas inlet for receiving two or more gases and a mixing chamber with a static mixer for mixing the gases. Preferred mixing chambers further comprise a reduced pressure compartment downstream of the static mixer that is in fluid communication with the gas inlet. A gas outlet is in fluid communication with the mixing chamber, and one or more sensors are coupled to the reduced pressure compartment and are configured to continuously sense various parameters such as barometric pressure and the percentage of oxygen in the gas mixture moving through the mixing device. Most typically, the readings of the sensor are pre-compensated for temperature, pressure, and humidity. Also provided herein are methods for using the same.Type: ApplicationFiled: December 18, 2019Publication date: June 18, 2020Inventors: Royal Q. Le, Kyong Son, Barry E. Rothenberg
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Patent number: 10138455Abstract: A incubator chamber comprises a base, lid and plurality of trays, each of which are stackable upon one another in an open or closed configuration. A clamp could be provided having an interior cavity sized and dimensioned to simultaneously receive a portion of a perimeter of each of a base and a lid.Type: GrantFiled: March 15, 2016Date of Patent: November 27, 2018Inventor: Barry E. Rothenberg
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Publication number: 20160194596Abstract: A incubator chamber comprises a base, lid and plurality of trays, each of which are stackable upon one another in an open or closed configuration. A clamp could be provided having an interior cavity sized and dimensioned to simultaneously receive a portion of a perimeter of each of a base and a lid.Type: ApplicationFiled: March 15, 2016Publication date: July 7, 2016Inventor: Barry E. Rothenberg
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Patent number: 9315769Abstract: A incubator chamber comprises a base, lid and plurality of trays, each of which are stackable upon one another in an open or closed configuration. A clamp could be provided having an interior cavity sized and dimensioned to simultaneously receive a portion of a perimeter of each of a base and a lid.Type: GrantFiled: December 2, 2013Date of Patent: April 19, 2016Assignee: Billups-Rothenberg, Inc.Inventor: Barry E. Rothenberg