Abstract: A process for evaluating space systems for safety assurance and residual risk to the flight crew. The process includes a success oriented System Safety phase which attempts to reduce the probability of failure with respect to the loss of a crew member as low as practical; a failure oriented SPACESAFE phase which assumes that at least one Safety Critical Subsystem has failed and attempts to engineer a risk mitigation design minimize adverse effects on the crew; and an Integration phase which complimentary integrates the System Safety phase with the SPACESAFE phase. Such process allows for increased flight crew safety by minimizing risk of a failures that contribute to loss of a crew member.