Abstract: A standalone integrated digital audio workstation (DAW) including: a single housing; embedded multi-channel analog-to-digital (A/D) and digital-to-analog (D/A) converters within the single housing; a recording engine, coupled to the A/D and D/A converters for recording multiple tracks of audio at one or more sampling rates using a near-zero jitter clock signal in a record mode; recording media for storing the multiple tracks to create native recording files during the recording mode; and one or more processors, within the single housing, to edit, mix, and prepare final production files without the use of a separate computer in a DAW mode using directly the native recording files. Embodiments also relate to a studio system with a DAW and method of use.

Abstract: A system for determining whether a subject is breathing through his nose or mouth and providing feedback to the user. The feedback may take the form of an alarm signal or an instruction to the user. The system advantageously uses an acoustic sensor placed in the user's suprasternal notch.

Abstract: A medication delivery device for delivering a medicament by inhalation, said device comprising a housing (2) defining a chamber adapted to receive a metered dose of medication from a medication dispensing device, such as a pressurised metered dose inhaler canister or a dry powder inhaler, said chamber having an outlet (4) communicating with a mouthpiece of the device whereby said metered dose of medication can be withdrawn from the chamber via the mouthpiece by inhalation by a patient, said chamber being provided with a moveable wall (5) moveable between a first position and a second position, whereby said moveable wall is arranged to move from its first position to its second position as a patient withdraws a dose of medication from the chamber by inhalation to verify complete inhalation of said dose of medication. FIG.

Abstract: The invention combines a microarray and cell-based screening strategy that enables rapid identification of possible mechanisms underpinning the pharmacology and toxicology of drug candidates. The methods of the invention identified unique properties relating to apoptosis and the anti-inflammatory response elicited by several peroxisome proliferator activated receptor gamma (PPAR?) ligands. The methods illustrate, for example, that PPAR? ligands that are safe and effective drugs (e.g., Actos, Avandia) either do not induce apoptosis or only modestly induce apoptosis. Conversely, PPAR? ligands that have failed clinical development (e.g., Ciglitazone; Day, C., Diabet. Med., 16: 179-192 (1999)) or that have been withdrawn from the market (e.g., Troglitazone (Rezulin)) due to hepatotoxicity are potent inducers of apoptosis.

Abstract: The identification and evaluation of mRNA and protein targets associated with RNA binding proteins or mRNP complexes is described. In particular, the invention provides methods for identifying RNA binding proteins associated with physiological pathways that participate in glucose and lipid metabolism and mRNAs that exhibit coordinated gene regulation across those M pathways. Candidate targets are provided that are useful for the diagnosis or treatment of diseases related to diseases, such as disease related to aberrant glucose and lipid metabolism, such as, for example, obesity, diabetes, and hypoglycemia.

Abstract: A method, system, and computer program software for an emergency management and response mission support platform for facilitating communication between a plurality of emergency response and management organizations is provided. In one embodiment, the platform includes an incident management and response unit and a portal. The incident management and response unit coordinates information between a plurality of emergence management and response organizations and provides substantially real-time operational information, such as, for example, location of emergency personnel and assets from a plurality of organizations, emergency response plans, and evacuation plan analysis, and delivers this information to users via a portal which provides a user interface to view content provided by the incident management and response unit.

Abstract: A point-of-sale (POS) system includes a POS host terminal that includes a first POS management module that is configured to facilitate a POS transaction. A peripheral device, which may be for example, a smart card/debit card reader with an optional signature capture, is communicatively coupled to the POS host terminal and includes a second POS management module that is configured to facilitate the POS transaction with the POS host terminal being under the control of the peripheral device.