Patents by Inventor Barry J. Hand
Barry J. Hand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220073652Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.Type: ApplicationFiled: September 21, 2021Publication date: March 10, 2022Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Publication number: 20220073651Abstract: The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.Type: ApplicationFiled: September 21, 2021Publication date: March 10, 2022Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Barry J. Hand, Eyal S. Ron
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Patent number: 11130824Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.Type: GrantFiled: March 9, 2020Date of Patent: September 28, 2021Assignee: Gelesis LLCInventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Publication number: 20200277407Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.Type: ApplicationFiled: March 9, 2020Publication date: September 3, 2020Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Patent number: 10584183Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.Type: GrantFiled: December 14, 2018Date of Patent: March 10, 2020Assignee: Gelesis, LLCInventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Publication number: 20190233545Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.Type: ApplicationFiled: December 14, 2018Publication date: August 1, 2019Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Patent number: 10179824Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.Type: GrantFiled: January 29, 2016Date of Patent: January 15, 2019Assignee: GELESIS LLCInventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Patent number: 10098907Abstract: The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.Type: GrantFiled: April 24, 2017Date of Patent: October 16, 2018Assignee: GELESIS LLCInventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Patent number: 9926287Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: GrantFiled: November 18, 2016Date of Patent: March 27, 2018Assignee: Phyton Holdings, LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Publication number: 20170304356Abstract: The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.Type: ApplicationFiled: April 24, 2017Publication date: October 26, 2017Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Publication number: 20170066734Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: ApplicationFiled: November 18, 2016Publication date: March 9, 2017Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Patent number: 9527825Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: GrantFiled: February 25, 2016Date of Patent: December 27, 2016Assignee: Phyton Holdings, LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
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Publication number: 20160222134Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.Type: ApplicationFiled: January 29, 2016Publication date: August 4, 2016Inventors: Alessandro Sannino, Christian Demitri, Yishai Zohar, Eyal S. Ron, Barry J. Hand, Cosimo Saponaro
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Publication number: 20160176837Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: ApplicationFiled: February 25, 2016Publication date: June 23, 2016Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Patent number: 9303004Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: GrantFiled: February 24, 2014Date of Patent: April 5, 2016Assignee: Phyton Holdings, LLCInventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Publication number: 20150005517Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: ApplicationFiled: February 24, 2014Publication date: January 1, 2015Applicant: Phyton Holdings LLCInventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Patent number: 8703982Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: GrantFiled: February 12, 2010Date of Patent: April 22, 2014Assignee: Phyton Holdings LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James A. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
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Patent number: 7897796Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: GrantFiled: June 18, 2007Date of Patent: March 1, 2011Assignee: Phyton Holdings, LLCInventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Publication number: 20110021729Abstract: The present invention relates in part to poly(styrene-co-maleic anhydride/acid) copolymers having high purity, for example, having low amounts of maleic acid, maleic anhydride, and/or styrene. The present invention also relates in parts to methods of purifying poly(styrene-co-maleic anhydride/acid) copolymers to remove the residual monomers and low molecular weight fragments.Type: ApplicationFiled: March 19, 2010Publication date: January 27, 2011Inventors: Eyal S. Ron, Yishai Zohar, Barry J. Hand, Mircea Dan Bucevschi, Monica Colt
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Publication number: 20100145080Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: ApplicationFiled: February 12, 2010Publication date: June 10, 2010Applicant: Phyton Holdings LLCInventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang