Patents by Inventor Barry J. Marshall

Barry J. Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8992935
    Abstract: The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified Helicobacter pylori comprising a functional urease, wherein the contiguous amino acid sequence between amino acid 529 and amino acid 555 of SEQ ID NO:1 is altered to produce said modified Helicobacter pylori which is unable to establish or maintain a persistent infection.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: March 31, 2015
    Assignee: Ondek Pty. Ltd.
    Inventors: Mohammed Benghezal, Tobias Schoep, Alma Fulurija, Douglas E. Berg, Barry J. Marshall
  • Patent number: 8790909
    Abstract: The present invention relates to strains of Helicobacter pylori useful for the delivery of biologically active agents. In particular, the present invention provides an isolated strain of H. pylori having: (a) low pathogenicity; (b) ability to naturally transform; and (c) ability to colonise mouse stomach mucosa without host adaptation.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: July 29, 2014
    Assignee: Ondek Pty. Ltd.
    Inventors: Mohammed Benghezal, Alma Fulurija, Wei Lu, Hans-Olof Nilsson, Barry J. Marshall
  • Patent number: 8715929
    Abstract: The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a promoter operably-linked to at least two genes, wherein at least one gene is a gene of interest and at least one gene is a gene essential to said bacterium.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: May 6, 2014
    Assignee: Ondek Pty. Ltd.
    Inventors: Mohammed Benghezal, Yakhya Dieye, Carola Schwann, Miriam Sehnal, Alma Fulurija, Barry J. Marshall
  • Publication number: 20130259888
    Abstract: The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified Helicobacter pylori comprising a functional urease, wherein the contiguous amino acid sequence between amino acid 529 and amino acid 555 of SEQ ID NO:1 is altered to produce said modified Helicobacter pylori which is unable to establish or maintain a persistent infection.
    Type: Application
    Filed: June 24, 2011
    Publication date: October 3, 2013
    Applicant: ONDEK PTY LTD
    Inventors: Mohammed Benghezal, Tobias Schoep, Alma Fulurija, Douglas E. Berg, Barry J. Marshall
  • Patent number: 8420374
    Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: April 16, 2013
    Assignee: Ondek Pty. Ltd.
    Inventor: Barry J. Marshall
  • Patent number: 8298806
    Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: October 30, 2012
    Assignee: Ondek Pty. Ltd.
    Inventor: Barry J. Marshall
  • Patent number: 8298527
    Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: October 30, 2012
    Assignee: Ondek Pty. Ltd.
    Inventor: Barry J. Marshall
  • Publication number: 20120225454
    Abstract: The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a promoter operably-linked to at least two genes, wherein at least one gene is a gene of interest and at least one gene is a gene essential to said bacterium.
    Type: Application
    Filed: June 25, 2010
    Publication date: September 6, 2012
    Applicant: ONDEK PTY LTD
    Inventors: Mohammed Benghezal, Yakhya Dieye, Carola Schwann, Miriam Sehnal, Alma Fulurija, Barry J. Marshall
  • Publication number: 20120177682
    Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.
    Type: Application
    Filed: September 2, 2011
    Publication date: July 12, 2012
    Inventor: Barry J. Marshall
  • Publication number: 20110274719
    Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent.
    Type: Application
    Filed: April 29, 2011
    Publication date: November 10, 2011
    Inventor: Barry J. Marshall
  • Patent number: 8029777
    Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: October 4, 2011
    Inventor: Barry J. Marshall
  • Patent number: 7968324
    Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharmacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: June 28, 2011
    Inventor: Barry J Marshall
  • Publication number: 20090220540
    Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent.
    Type: Application
    Filed: May 14, 2009
    Publication date: September 3, 2009
    Inventor: Barry J. Marshall
  • Patent number: 7087398
    Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: August 8, 2006
    Inventors: Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
  • Patent number: 7037275
    Abstract: A gastrointestinal sampling device that increases the number of epithelial cells removed from the stomach lining without causing additional discomfort to the patient, and which is particularly useful for obtaining samples from the gastric mucus and between the epithelial cells of the stomach. It comprises a drag material (12) for obtaining a gastrointestinal sample and a protective sheath (22) for deployment about the drag material such that the drag material is substantially enclosed by the protective sheath upon removal from the gastrointestinal tract.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: May 2, 2006
    Assignee: The University of Western Australia
    Inventors: Barry J. Marshall, Agnes Mei-Ling Wong
  • Patent number: 7008777
    Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: March 7, 2006
    Inventors: Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
  • Patent number: 6998250
    Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. The system includes a carrier having a first well and a second well. A first composition is disposed in the first well and contains urea in powdered form. A second composition is disposed in a second well and contains an indicator. A biopsy of a gastric sample is manipulated with a specimen-handling tool and is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme, which, in turn, indicates the presence of bacteria.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: February 14, 2006
    Inventors: Donald J. McMichael, Kristy Peterson, Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
  • Patent number: 6929926
    Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: August 16, 2005
    Inventors: Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
  • Publication number: 20030082661
    Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. The system includes a carrier having a first well and a second well. A first composition is disposed in the first well and contains urea in powdered form. A second composition is disposed in a second well and contains an indicator. A biopsy of a gastric sample is manipulated with a specimen-handling tool and is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme, which, in turn, indicates the presence of bacteria.
    Type: Application
    Filed: October 15, 2001
    Publication date: May 1, 2003
    Inventors: Donald J. McMichael, Kristy Peterson, Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
  • Publication number: 20030082664
    Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.
    Type: Application
    Filed: October 15, 2001
    Publication date: May 1, 2003
    Applicant: Kimberly-Clark Worldwide, Inc.
    Inventors: Barry J. Marshall, Aruni H.W. Mendis, Simon Chairman