Patents by Inventor Barry J. Marshall
Barry J. Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8992935Abstract: The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified Helicobacter pylori comprising a functional urease, wherein the contiguous amino acid sequence between amino acid 529 and amino acid 555 of SEQ ID NO:1 is altered to produce said modified Helicobacter pylori which is unable to establish or maintain a persistent infection.Type: GrantFiled: June 24, 2011Date of Patent: March 31, 2015Assignee: Ondek Pty. Ltd.Inventors: Mohammed Benghezal, Tobias Schoep, Alma Fulurija, Douglas E. Berg, Barry J. Marshall
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Patent number: 8790909Abstract: The present invention relates to strains of Helicobacter pylori useful for the delivery of biologically active agents. In particular, the present invention provides an isolated strain of H. pylori having: (a) low pathogenicity; (b) ability to naturally transform; and (c) ability to colonise mouse stomach mucosa without host adaptation.Type: GrantFiled: June 3, 2010Date of Patent: July 29, 2014Assignee: Ondek Pty. Ltd.Inventors: Mohammed Benghezal, Alma Fulurija, Wei Lu, Hans-Olof Nilsson, Barry J. Marshall
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Patent number: 8715929Abstract: The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a promoter operably-linked to at least two genes, wherein at least one gene is a gene of interest and at least one gene is a gene essential to said bacterium.Type: GrantFiled: June 25, 2010Date of Patent: May 6, 2014Assignee: Ondek Pty. Ltd.Inventors: Mohammed Benghezal, Yakhya Dieye, Carola Schwann, Miriam Sehnal, Alma Fulurija, Barry J. Marshall
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Publication number: 20130259888Abstract: The present invention relates to a means of controlling infection persistence of Helicobacter pylori (H. pylori). In particular, the present invention relates to an isolated, genetically modified Helicobacter pylori comprising a functional urease, wherein the contiguous amino acid sequence between amino acid 529 and amino acid 555 of SEQ ID NO:1 is altered to produce said modified Helicobacter pylori which is unable to establish or maintain a persistent infection.Type: ApplicationFiled: June 24, 2011Publication date: October 3, 2013Applicant: ONDEK PTY LTDInventors: Mohammed Benghezal, Tobias Schoep, Alma Fulurija, Douglas E. Berg, Barry J. Marshall
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Patent number: 8420374Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.Type: GrantFiled: September 2, 2011Date of Patent: April 16, 2013Assignee: Ondek Pty. Ltd.Inventor: Barry J. Marshall
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Patent number: 8298806Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided.Type: GrantFiled: May 14, 2009Date of Patent: October 30, 2012Assignee: Ondek Pty. Ltd.Inventor: Barry J. Marshall
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Patent number: 8298527Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided.Type: GrantFiled: April 29, 2011Date of Patent: October 30, 2012Assignee: Ondek Pty. Ltd.Inventor: Barry J. Marshall
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Publication number: 20120225454Abstract: The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a promoter operably-linked to at least two genes, wherein at least one gene is a gene of interest and at least one gene is a gene essential to said bacterium.Type: ApplicationFiled: June 25, 2010Publication date: September 6, 2012Applicant: ONDEK PTY LTDInventors: Mohammed Benghezal, Yakhya Dieye, Carola Schwann, Miriam Sehnal, Alma Fulurija, Barry J. Marshall
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Publication number: 20120177682Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.Type: ApplicationFiled: September 2, 2011Publication date: July 12, 2012Inventor: Barry J. Marshall
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Publication number: 20110274719Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent.Type: ApplicationFiled: April 29, 2011Publication date: November 10, 2011Inventor: Barry J. Marshall
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Patent number: 8029777Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.Type: GrantFiled: November 10, 2006Date of Patent: October 4, 2011Inventor: Barry J. Marshall
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Patent number: 7968324Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharmacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided.Type: GrantFiled: August 12, 2005Date of Patent: June 28, 2011Inventor: Barry J Marshall
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Publication number: 20090220540Abstract: Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and/or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent.Type: ApplicationFiled: May 14, 2009Publication date: September 3, 2009Inventor: Barry J. Marshall
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Patent number: 7087398Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.Type: GrantFiled: October 15, 2001Date of Patent: August 8, 2006Inventors: Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
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Patent number: 7037275Abstract: A gastrointestinal sampling device that increases the number of epithelial cells removed from the stomach lining without causing additional discomfort to the patient, and which is particularly useful for obtaining samples from the gastric mucus and between the epithelial cells of the stomach. It comprises a drag material (12) for obtaining a gastrointestinal sample and a protective sheath (22) for deployment about the drag material such that the drag material is substantially enclosed by the protective sheath upon removal from the gastrointestinal tract.Type: GrantFiled: August 31, 2000Date of Patent: May 2, 2006Assignee: The University of Western AustraliaInventors: Barry J. Marshall, Agnes Mei-Ling Wong
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Patent number: 7008777Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.Type: GrantFiled: October 15, 2001Date of Patent: March 7, 2006Inventors: Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
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Patent number: 6998250Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. The system includes a carrier having a first well and a second well. A first composition is disposed in the first well and contains urea in powdered form. A second composition is disposed in a second well and contains an indicator. A biopsy of a gastric sample is manipulated with a specimen-handling tool and is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme, which, in turn, indicates the presence of bacteria.Type: GrantFiled: October 15, 2001Date of Patent: February 14, 2006Inventors: Donald J. McMichael, Kristy Peterson, Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
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Patent number: 6929926Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.Type: GrantFiled: October 15, 2001Date of Patent: August 16, 2005Inventors: Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman
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Publication number: 20030082664Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second composition, on the other hand, contains an indicator. A biopsy of a gastric sample is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme that, in turn, indicates the presence of bacteria. In an alternative embodiment of the present invention, a biopsy of a gastric sample is contacted with a single composition. The composition contains urea in a powdered form combined with a dry indicator. Besides urea and a dry indicator, the composition can also contain an anti-caking agent.Type: ApplicationFiled: October 15, 2001Publication date: May 1, 2003Applicant: Kimberly-Clark Worldwide, Inc.Inventors: Barry J. Marshall, Aruni H.W. Mendis, Simon Chairman
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Publication number: 20030082661Abstract: A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. The system includes a carrier having a first well and a second well. A first composition is disposed in the first well and contains urea in powdered form. A second composition is disposed in a second well and contains an indicator. A biopsy of a gastric sample is manipulated with a specimen-handling tool and is first contacted with the first composition and then placed in the second composition. The second composition indicates the presence of an enzyme, which, in turn, indicates the presence of bacteria.Type: ApplicationFiled: October 15, 2001Publication date: May 1, 2003Inventors: Donald J. McMichael, Kristy Peterson, Barry J. Marshall, Aruni H. W. Mendis, Simon Chairman