Patents by Inventor Barry J. Simon, M.D.

Barry J. Simon, M.D. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Elimination of BCMA-positive malignancies by CAR expressing NK cells
    Publication number: 20230172982
    Abstract: Provided are genetically modified NK cells expressing a chimeric antigen receptor targeting an BCMA superfamily receptor. The CAR can comprise an intracellular domain of Fc?RI? and further recombinant proteins expressed by the genetically modified NK cells are CD16, autocrine growth stimulating cytokines, and optionally one of IL-12, a TGF-beta trap, or a homing receptor. Also described are methods for treating a patient having or suspected of having a disease that is treatable with NK-92 cells, such as cancer, comprising administering to the patient the genetically modified NK cells.
    Type: Application
    Filed: January 30, 2020
    Publication date: June 8, 2023
    Inventors: Laurent H. Boissel, Hans G. Klingemann, Barry J. Simon, M.D., Abhijit Dandapat
  • Nant Cancer Vaccine
    Publication number: 20230034802
    Abstract: Cancer is treated using coordinated treatment regimens that uses various compounds and compositions that drive a tumor from the escape phase of cancer immunoediting to the elimination and equilibrium phase of cancer immunoediting.
    Type: Application
    Filed: August 3, 2022
    Publication date: February 2, 2023
    Inventors: Patrick Soon-Shiong, Kayvan NIAZI, Shahrooz RABIZADEH, Hans G. Klingemann, Laurent H. Boissel, Barry J. Simon, M.D.