Patents by Inventor Barry J. Spargo
Barry J. Spargo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10563158Abstract: Disclosed is an apparatus having: a pressure chamber and a gas-producing microorganism within the chamber. The pressure chamber is capable of maintaining a gas pressure of at least 0.5 psi above atmospheric pressure.Type: GrantFiled: May 3, 2016Date of Patent: February 18, 2020Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Barry J. Spargo, Justin C. Biffinger, Bradley R. Ringeisen, Erinn C. (Howard) Pirlo, Lisa A. Fitzgerald, Peter K. Wu, Michael P. Malito
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Patent number: 9663194Abstract: A device having: a chamber having a gas inlet, a gas vent, and a liquid vent; and a float and a weight coupled to the chamber. The float has a lower density than the chamber. The weight has a higher density than the chamber. The aggregate density of the chamber, the float, and the weight is greater than the density of the chamber. The gas inlet, the gas vent, the liquid vent, the float, and the weight are positioned on the chamber such that: when the chamber is filled with and submerged in a liquid in which the chamber is neutrally-buoyant, the chamber is oriented to place the gas vent below the gas inlet; and when a gas is introduced through the gas inlet into the chamber that is filled with the liquid, the chamber pivots to raise the gas vent until a portion of the gas escapes from the chamber through only the gas vent.Type: GrantFiled: February 5, 2010Date of Patent: May 30, 2017Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Bradley R Ringeisen, Peter K Wu, Barry J Spargo, Justin C Biffinger, Lisa A. Fitzgerald
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Publication number: 20160244706Abstract: Disclosed is an apparatus having: a pressure chamber and a gas-producing microorganism within the chamber. The pressure chamber is capable of maintaining a gas pressure of at least 0.5 psi above atmospheric pressure.Type: ApplicationFiled: May 3, 2016Publication date: August 25, 2016Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Barry J. Spargo, Justin C. Biffinger, Bradley R. Ringeisen, Erinn C. (Howard) Pirlo, Lisa A. Fitzgerald, Peter K. Wu, Michael P. Malito
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Patent number: 9327804Abstract: Disclosed is an apparatus having: a pressure chamber and a gas-producing microorganism within the chamber. The pressure chamber is capable of maintaining a gas pressure of at least 0.5 psi above atmospheric pressure.Type: GrantFiled: May 20, 2011Date of Patent: May 3, 2016Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Barry J Spargo, Justin C Biffinger, Bradley R Ringeisen, Erinn C. Howard, Lisa A. Fitzgerald, Peter K Wu, Michael P. Malito
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Publication number: 20110229951Abstract: Disclosed is an apparatus having: a pressure chamber and a gas-producing microorganism within the chamber. The pressure chamber is capable of maintaining a gas pressure of at least 0.5 psi above atmospheric pressure.Type: ApplicationFiled: May 20, 2011Publication date: September 22, 2011Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Barry J. Spargo, Justin C. Biffinger, Bradley R. Ringeisen, Erinn C. Howard, Lisa A. Fitzgerald, Peter K. Wu, Michael P. Malito
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Patent number: 7854857Abstract: A safe, biodegradable, environmentally benign, non-toxic, water-soluble solution consisting of water, sugar, starch, sodium phosphate, and surfactant that can be applied to dust and sand particles to bind the particles and form a hardened crust. Also disclosed is the related method for abating dust and preventing erosion.Type: GrantFiled: October 30, 2009Date of Patent: December 21, 2010Assignee: The United States of America as represented by the Secretary of the NavyInventors: James H Wynne, Barry J Spargo, Christopher T Lloyd, Warren W Schultz
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Publication number: 20100199907Abstract: A device having: a chamber having a gas inlet, a gas vent, and a liquid vent; and a float and a weight coupled to the chamber. The float has a lower density than the chamber. The weight has a higher density than the chamber. The aggregate density of the chamber, the float, and the weight is greater than the density of the chamber. The gas inlet, the gas vent, the liquid vent, the float, and the weight are positioned on the chamber such that: when the chamber is filled with and submerged in a liquid in which the chamber is neutrally-buoyant, the chamber is oriented to place the gas vent below the gas inlet; and when a gas is introduced through the gas inlet into the chamber that is filled with the liquid, the chamber pivots to raise the gas vent until a portion of the gas escapes from the chamber through only the gas vent.Type: ApplicationFiled: February 5, 2010Publication date: August 12, 2010Applicant: The Government of The United States of America, as represented by the Secretary of the NavyInventors: Bradley R. Ringeisen, Peter K. Wu, Barry J. Spargo, Justin C. Biffinger, Lisa A. Fitzgerald
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Publication number: 20100047443Abstract: A safe, biodegradable, environmentally benign, non-toxic, water-soluble solution consisting of water, sugar, starch, sodium phosphate, and surfactant that can be applied to dust and sand particles to bind the particles and form a hardened crust. Also disclosed is the related method for abating dust and preventing erosion.Type: ApplicationFiled: October 30, 2009Publication date: February 25, 2010Applicant: The Government of the United States of America, as represented by the secretary of the NavyInventors: James H. Wynne, Barry J. Spargo, Christopher T. Lloyd, Warren W. Schultz
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Publication number: 20040227126Abstract: A safe, biodegradable, environmentally benign, non-toxic, water-soluble solution consisting of water, sugar, starch, sodium phosphate, and surfactant that can be applied to dust and sand particles to bind the particles and form a hardened crust. Also disclosed is the related method for abating dust and preventing erosion.Type: ApplicationFiled: February 12, 2004Publication date: November 18, 2004Inventors: James H. Wynne, Barry J. Spargo, Christopher T. Lloyd, Warren W. Schultz
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Publication number: 20020127535Abstract: One aspect of the present invention is a method for storing tissues and cells (typically erythrocytes) having the step of (1) stabilizing the cells with a reversible stabilizing agent. This method typically will have the additional steps of (2) loading the cells with a cryoprotectant, and typically (3) storing the cells in liquid, frozen, or dry state. This method will also typically have the additional step of (4) prior to use, reversing the stabilization reaction. Preferably, the erythrocytes are pre-treated with CO to complex the hemoglobin with CO. It is anticipated that a practical method according to the invention will include reoxygenation of the erythrocytes, and also washing out reagents prior to in vivo use. Another aspect of the present invention is an erythrocyte that has had its shape stabilized by the reversible crosslinking of proteins in the erythrocyte, such as the structural proteins of the cytoskeleton.Type: ApplicationFiled: January 16, 2002Publication date: September 12, 2002Inventors: Irina B. Bakaltcheva, Alan S. Rudolph, Barry J. Spargo, Samuel B. Leslie, Thomas R. Groel
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Patent number: 6436705Abstract: One aspect of the present invention is a method for storing tissues and cells (typically erythrocytes) having the step of (1) stabilizing the cells with a reversible stabilizing agent. This method typically will have the additional steps of (2) loading the cells with a cryoprotectant, and typically (3) storing the cells in liquid, frozen, or dry state. This method will also typically have the additional step of (4) prior to use, reversing the stabilization reaction. Preferably, the erythrocytes are pre-treated with CO to complex the hemoglobin with CO. It is anticipated that a practical method according to the invention will include reoxygenation of the eryathrocytes, and also washing out reagents prior to in vivo use. Another aspect of the present invention is an erythrocyte that has had its shape stabilized by the reversible crosslinking of proteins in the erythrocyte, such as the structural proteins of the cytoskeleton.Type: GrantFiled: January 16, 2002Date of Patent: August 20, 2002Assignee: The United States of America as represented by the Secretary of the NavyInventors: Irina B. Bakaltcheva, Alan S. Rudolph, Barry J. Spargo, Samuel B. Leslie, Thomas R. Groel
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Patent number: 6358678Abstract: One aspect of the present invention is a method for storing tissues and cells (typically erythrocytes) having the step of (1) stabilizing the cells with a reversible stabilizing agent. This method typically will have the additional steps of (2) loading the cells with a cryoprotectant, and typically (3) storing the cells in liquid, frozen, or dry state. This method will also typically have the additional step of (4) prior to use, reversing the stabilization reaction. Preferably, the erythrocytes are pre-treated with CO to complex the hemoglobin with CO. It is anticipated that a practical method according to the invention will include reoxygenation of the erythrocytes, and also washing out reagents prior to in vivo use. Another aspect of the present invention is an erythrocyte that has had its shape stabilized by the reversible crosslinking of proteins in the erythrocyte, such as the structural proteins of the cytoskeleton.Type: GrantFiled: February 11, 1998Date of Patent: March 19, 2002Assignee: The United States of America as represented by the Secretary of the NavyInventors: Irina B. Bakaltcheva, Alan S. Rudolph, Barry J. Spargo, Samuel B. Leslie, Thomas R. Groel
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Patent number: 5736313Abstract: A process and medium are disclosed for the lyophilization of platelets. During lyophilization, carbohydrate-load platelets are supercooled while suspended in a buffer solution including a biocompatible polymer that serves to preserve the structure of the platelets. The supercooled platelets are then frozen at a temperature below the glass transition temperature of the suspension. A vacuum is placed on the frozen suspension to remove most of the water therefrom. Then, the temperature of the platelets is increased to the supercooled temperature while the vacuum is maintained. After being sealed under vacuum, the lyophilized platelets may be reconstituted to form viable, transfusable platelets. The reconstituted platelets have a high aggregation index, retain normal agglutination and degranulation capability, and are able to participate in clot formation.Type: GrantFiled: October 20, 1995Date of Patent: April 7, 1998Assignee: The United States of America as represented by the Secretary of the NavyInventors: Barry J. Spargo, Alan S. Rudolph, Richard G. Emler, Thomas R. Groel, II
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Patent number: 5721131Abstract: A process for forming spatially oriented neo-vascular capillaries comprising: (a) providing a combination ultra-thin film (UTF) pattern of at least one cell adhesion promoter and at least one cell adhesion inhibitor wherein the cell adhesion promoters have a linewidth of between about 50-490 .mu.m; (b) seeding the combination UTF pattern with endothelial cells at an initial seeding cell density; (c) adding a first medium for incubating the seeded endothelial cells until the endothelial cells are grown to confluency; (d) replacing the first medium with a second medium at confluency; and (e) allowing the endothelial cells to differentiate into spatially oriented neo-vascular capillaries.Type: GrantFiled: April 28, 1994Date of Patent: February 24, 1998Assignee: United States of America as represented by the Secretary of the NavyInventors: Alan S. Rudolph, Chih-Chang Chu, David A. Stenger, Barry J. Spargo, Jacque Georger
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Patent number: 5690963Abstract: A process and medium are disclosed for the lyophilization of cells, specifically red blood cells and platelets, and cell-like matter, which comprises the use of solution including a carbohydrate, and biocompatible polymers to permit reconstitution of transfusably useful cells which are viable by the measure of ATP and 2,3 DPG.Type: GrantFiled: June 30, 1995Date of Patent: November 25, 1997Assignee: The United States of America as represented by the Secretary of the NavyInventors: Barry J. Spargo, Alan S. Rudolph, Byeong S. Chang, Thomas R. Groel, II