Patents by Inventor Barry Jay Kappel

Barry Jay Kappel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ATF5 peptide variants and uses thereof
    Patent number: 12208131
    Abstract: Provided are ATF5 peptides having a truncated ATF5 leucine zipper region and, optionally, a cell-penetrating region, compositions comprising the ATF5 peptides, and methods of inhibiting proliferation of and promoting cytotoxicity in a neoplastic cell using the ATF5 peptides.
    Type: Grant
    Filed: December 9, 2023
    Date of Patent: January 28, 2025
    Assignee: Sapience Therapeutics, Inc.
    Inventors: Barry Jay Kappel, Gene Merutka, Jimmy Andrew Rotolo
  • ATF5 Peptide Variants and Uses Thereof
    Publication number: 20240181003
    Abstract: Provided are ATF5 peptides having a truncated ATF5 leucine zipper region and, optionally, a cell-penetrating region, compositions comprising the ATF5 peptides, and methods of inhibiting proliferation of and promoting cytotoxicity in a neoplastic cell using the ATF5 peptides.
    Type: Application
    Filed: December 9, 2023
    Publication date: June 6, 2024
    Inventors: Barry Jay Kappel, Gene Merutka, Jimmy Andrew Rotolo
  • ATF5 peptide variants and uses thereof
    Patent number: 11878047
    Abstract: Provided are ATF5 peptides having a truncated ATF5 leucine zipper region and, optionally, a cell-penetrating region, compositions comprising the ATF5 peptides, and methods of inhibiting proliferation of and promoting cytotoxicity in a neoplastic cell using the ATF5 peptides.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: January 23, 2024
    Assignee: Sapience Therapeutics, Inc.
    Inventors: Barry Jay Kappel, Gene Merutka, Jimmy Andrew Rotolo
  • Administration of CEBP-Beta Antagonist and Methods of Use
    Publication number: 20230218717
    Abstract: Provided are methods of administering a peptide antagonist of CCAAT/enhancer-binding protein beta (C/EBP?) and methods of treating solid tumors by administering a peptide antagonist of C/EBP?.
    Type: Application
    Filed: June 21, 2021
    Publication date: July 13, 2023
    Inventors: Barry Jay Kappel, Gene Merutka, Jimmy Andrew Rotolo, Alice Susannah Bexon, Robert E. Michel
  • Modified BCL9 Mimetic Peptides
    Publication number: 20220275036
    Abstract: Provided are BCL9 mimetic peptides having a modified a-helical homology domain-2 (HD2) region and, optionally, a cell-penetrating region, compositions comprising the BCL9 mimetic peptides, and methods of inhibiting proliferation of and/or promoting cytotoxicity in a neoplastic cell using the BCL9 mimetic peptides.
    Type: Application
    Filed: July 6, 2020
    Publication date: September 1, 2022
    Inventors: Barry Jay Kappel, Gene Merutka, Jimmy Andrew Rotolo, Erin E. Gallagher
  • ATF5 Peptide Variants and Uses Thereof
    Publication number: 20210061869
    Abstract: Provided are ATF5 peptides having a truncated ATF5 leucine zipper region and, optionally, a cell-penetrating region, compositions comprising the ATF5 peptides, and methods of inhibiting proliferation of and promoting cytotoxicity in a neoplastic cell using the ATF5 peptides.
    Type: Application
    Filed: January 3, 2019
    Publication date: March 4, 2021
    Inventors: Barry Jay Kappel, Gene Merutka, Jimmy Andrew Rotolo
  • ATF5 peptide variants and uses thereof
    Patent number: 10525100
    Abstract: Provided are activating transcription factor 5 (ATF5) peptides having a truncated ATF5 leucine zipper region and, optionally, a cell-penetrating region, compositions comprising the ATF5 peptides, and methods of inhibiting proliferation of and promoting cytotoxicity in a neoplastic cell using the ATF5 peptides.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: January 7, 2020
    Assignee: Sapience Therapeutics, Inc.
    Inventors: Barry Jay Kappel, Gene Merutka, Jimmy Andrew Rotolo
  • ATF5 Peptide Variants and Uses Thereof
    Publication number: 20190201483
    Abstract: Provided are ATF5 peptides having a truncated ATF5 leucine zipper region and, optionally, a cell-penetrating region, compositions comprising the ATF5 peptides, and methods of inhibiting proliferation of and promoting cytotoxicity in a neoplastic cell using the ATF5 peptides.
    Type: Application
    Filed: January 3, 2019
    Publication date: July 4, 2019
    Inventors: Barry Jay Kappel, Gene Merutka, Jimmy Andrew Rotolo
  • Cell-penetrating ATF5 polypeptides and uses thereof
    Patent number: 10316077
    Abstract: Provided are cell-penetrating ATF5 polypeptides having a cell-penetrating region and an ATF5 leucine zipper region, compositions comprising the ATF5 polypeptides, and methods of treating a tumor and promoting cytotoxicity in a neoplastic cell using the ATF5 polypeptides.
    Type: Grant
    Filed: February 17, 2018
    Date of Patent: June 11, 2019
    Assignee: Sapience Therapeutics, Inc.
    Inventors: Barry Jay Kappel, Jimmy Andrew Rotolo, Gene Merutka
  • Cell-Penetrating ATF5 Polypeptides and Uses Thereof
    Publication number: 20180237499
    Abstract: Provided are cell-penetrating ATF5 polypeptides having a cell-penetrating region and an ATF5 leucine zipper region, compositions comprising the ATF5 polypeptides, and methods of treating a tumor and promoting cytotoxicity in a neoplastic cell using the ATF5 polypeptides.
    Type: Application
    Filed: February 17, 2018
    Publication date: August 23, 2018
    Inventors: Barry Jay Kappel, Jimmy Andrew Rotolo, Gene Merutka