Abstract: A combined eyelid warming device, resonance frequency generator, coupling device, and tissue response sensor are disclosed in the field of use in dry eye treatment. These combined devices are used to ensure that the entire eyelid surface and periorbital structures receive defined therapeutic warmth and appropriately tuned harmonic resonance frequency for a required period of time to stimulate flow from the Meibomian glands. The combined elements of the invention include an easily moldable heating disc, targeted formulation of the heating material, miniaturized resonant frequency vibrating generator combined with a properly designed reusable mask, to ensure precise location of the heat. Vibration may be delivered continuously or intermittently, and may be delivered according to one or more patterns. A chemical sensor is included to characterize flow as vibration is varied.