Abstract: Systems and methods for stimulating neural tissue are disclosed. An array of optically emissive pixels is configured to deliver light to the neural tissue of a subject. Individual pixels within the array can be addressed to selectively illuminate a portion of the neural tissue when a neurological event occurs. The system can also include an array of microelectrodes in electrical communication with the array of pixels and a power source. A biocompatible substrate can be used to support the microelectrodes pixels, and the power source. A microelectrode circuit and a pixel circuit can also be supported by the biocompatible substrate.

Abstract: A guide extension catheter assembly including a guide extension catheter and a support device. The guide extension catheter includes a shaft and a tubular member. The support device includes a push member and a shuttle member. The guide extension catheter assembly is configured to selectively provide a delivery state in which at least a portion of the shuttle member is disposed within the lumen, a leading end of the shuttle member is distal a distal end of the tubular member, and the shuttle member is directly, physically connected to the tubular member. In the delivery state, a longitudinal distal force applied to the push member is transferred to the tubular member as a longitudinal distal force via the shuttle member. The guide extension catheter assemblies of the present disclosure can promote a two stage guide extension catheter deployment.

Abstract: Medical devices for positioning a valve in a subject's body, such as a prosthetic heart valve in a subject's heart, are disclosed. The prosthetic heart valve may include a valve assembly, a frame, and a control arm. The prosthetic heart valve may include a commissural post or multiple commissural posts. The prosthetic heart valve may include a positional marker on a control arm. The prosthetic heart valve may include multiple positional markers on one or more control arms. The positional markers can be shapes, characters, or other symbols. The positional markers may themselves be asymmetric. The positional markers may be placed in an asymmetric location on a control arm. The control arm may be asymmetrically shaped.

Abstract: A catheter may include an elongate body extending from a proximal end to a distal end and defining a lumen; a push member mechanically coupled to the proximal end of the elongate body; and a slidable push grip disposed about an outer perimeter of the push member. The slidable push grip is controllably engageable with the push member. When the slidable push grip is in an engaged state with the push member, the slidable push grip transmits an axial force to the push member to enable the push member to transmit the axial force to the elongate body. When the slidable push grip is in a disengaged state with the push member, the slidable push grip is movable axially in at least one direction along a length of the push member while transmitting substantially no axial force to the push member.

Abstract: In some examples, a catheter may include an elongate body and a push assembly. The elongate body may include an inner liner defining an entry port into a lumen defined by the elongate body, and an outer jacket. The push assembly may an anchor member positioned at a distal end of an elongate member. Distal to a proximal end of the elongate body, a first portion of the push assembly, comprising the anchor member, may be positioned between a portion of the inner liner and a portion of the outer jacket. The anchor member may extend only partially around an outer perimeter of the inner liner when the catheter is assembled. Proximal to the proximal end of the elongate body, a second portion of the push assembly, proximal to the first portion, may be positioned outside of the outer jacket and the inner liner.

Abstract: A catheter may include an elongate body including a proximal portion including a proximal end, and a distal tip portion. The distal tip portion may include an inner liner and a marker band circumferentially surrounding the inner liner. The distal tip portion also may include an outer jacket circumferentially surrounding a first portion of the inner liner and ending proximal of a proximal end of the marker band; and a tip outer jacket circumferentially surrounding a second portion of the inner liner and the marker band. The tip outer jacket extends distally past the marker band distal end to a distal tip of the elongate body, and a proximal end of the tip outer jacket may be laterally adjacent to a distal end of the outer jacket.

Abstract: A system provides a listener application which can be notified about specific ports used by specific instances of a Web Socket application. A Web Socket application opens multiple dynamic ports in certain scenarios with a dynamic context. When an application is executed, a listener application is made aware of the context and port information. A system rewrites a reverse proxy configuration on the fly so that any request coming into the reverse proxy will read the change and assign the correct port. A notification to the listener is received across multiple nodes, and the configuration can be updated on all nodes based on the data provided in the configuration.

Abstract: A delivery system for an implantable medical device includes a tool and a tethering member extending side-by-side within an inner shaft thereof; the tool extends within a first lumen, being in sliding engagement therein, and includes a distal end coupling feature that protrudes from a distal end of the inner shaft; and the tethering member has a first segment extending within a second lumen, and a second segment extending from the first segment and distally from the distal end of the inner shaft to an end of the tethering member, which is configured to engage with a holding member of the device, and with which the coupling feature of the tool is configured to couple. A retainer may be joined to another end of the tethering member that protrudes from a proximal port of the system.

Abstract: A guide extension catheter includes a proximal shaft, a distal shaft, and a plurality of perfusion openings. The distal shaft includes a jacket and a helical coil structure embedded in the jacket, the distal shaft defining a lumen. The plurality of perfusion openings are disposed though the jacket of the distal shaft between windings of the helical coil structure. The guide extension catheter provides additional back support to the guide catheter. The plurality of perfusion openings allow fluid communication between an area outside the guide extension catheter and the lumen.

Abstract: A catheter for measuring a fractional flow reserve includes a proximal shaft, a distal shaft coupled to a distal portion of the proximal shaft, and a pressure sensor coupled to the distal shaft. The proximal shaft includes a distal portion configured to extend through a stenosis in a vessel. The distal portion of the proximal shaft includes a radially expanded configuration having a first diameter and a radially collapsed configuration having a second diameter, wherein the first diameter is larger than the second diameter. The distal shaft includes a guidewire lumen configured to receive therein.

Abstract: A catheter for measuring a fractional flow reserve includes a proximal shaft, a distal shaft coupled to the proximal shaft, a pressure sensor coupled to the distal shaft, and at least one pressure sensor wire operably connected to the pressure sensor. The proximal shaft includes a radially expanded configuration and a radially collapsed configuration, wherein the proximal shaft has a first outer diameter in the radially expanded configuration and a second outer diameter smaller than the first outer diameter in the radially collapsed configuration. The distal shaft defines a guidewire lumen configured to receive a guidewire therein.

Abstract: A processing system received data from a Fractional Flow Reserve device and communicates data to a conventional hemodynamic monitoring system having pressure displays. The processing system receives proximal pressure measurement signal from an aortic pressure measurement device and a distal pressure measurement signal from a distal pressure measurement device. A processor computes an FFR ratio from the proximal pressure measurement signal and the distal pressure measurement signal, and converts FFR ratio to a pressure format such that the FFR ratio reads on the conventional hemodynamic monitoring system as a pressure in units of pressure. The processing system transmits the proximal pressure measurement signal, the distal pressure measurement signal, and the FFR ratio in pressure format to the conventional hemodynamic monitoring system.

Abstract: A catheter is disclosed for providing a pressure measurement at a vascular lesion. The catheter includes a tubular component having dual lumens along at least a segment thereof in which a first lumen acts as a pressure inlet and a second lumen allows the catheter to be tracked over a guidewire. A plurality of openings are located along a distal segment of the tubular component that permit blood flow into the first lumen when disposed in vivo. A pressure sensor is located within a handle component of the catheter or within the tubular component to be in fluid communication with a proximal end of the first lumen. When the catheter is positioned at the vascular lesion, the first lumen fills with blood via the plurality of openings such that the pressure sensor is able to sense a pressure of the blood at a distal end of the catheter.

Abstract: Very strong, complex, unforgettable passwords unique to each web site are created for a user's Web site authentication by altering all or part of the web site address using, in a preferred embodiment, a predetermined encoding dictionary with more a single code for each entry. The entries in this preferred embodiment are single characters including characters used for words, punctuation, symbols and numerals; each single entry character appears more than once in the dictionary. The codes are of various character lengths and can be comprised of the same characters used in the entries. In an embodiment for pass-protecting files, the string of characters altered by encoding can be a private word or group of words. In another embodiment the password created by encoding is pseudo-randomly scrambled by using a seed unique to the user in order to create the password actually used.

Abstract: Transcatheter delivery systems, delivery catheters and associated methods for percutaneous delivery of prosthetic mitral valves using a retrograde approach are disclosed herein. A heart valve delivery system configured in accordance herewith includes a delivery catheter having an elongated tubular component and an articulation assembly at a distal end thereof. The articulation assembly includes an arm portion coupled to the tubular component by an elbow or hinge portion. In a closed, delivery state, the elbow portion positions the arm portion generally parallel to the tubular component for delivery of the delivery catheter through the vasculature. In an open, deployed state, the elbow portion positions the arm portion in a non-axial direction with respect to a longitudinal axis of the tubular component for orienting and positioning a prosthetic valve device carried by the arm portion, e.g., within the native mitral valve region.

Abstract: Various embodiments are generally directed to techniques for evaluating video quality of compressed versions of a motion video to select compressed frames of that motion video without access to an uncompressed version. A device to transmit motion video includes a device scoring component to select a set of coefficients from a vector correlating temporal complexity values to sets of coefficients based on a temporal complexity of a first compressed frame of a first compressed video data, the vector derived from opinion scores associated with at least one viewing characteristic of a viewing device; and a selection component to select either the first compressed frame or a second compressed frame of a second compressed data to transmit to the viewing device based on a metric of video quality derived from the selected set of coefficients, the first and second compressed data representing a motion video. Other embodiments are described and claimed.

Abstract: A catheter is disclosed for providing pressure measurements at a vascular lesion. The catheter includes an outer component having a side opening the providing transverse access to a lumen thereof and an inner component slidably disposed within the lumen. The inner component has a guidewire lumen with a proximal side port. When the inner component is longitudinally translated relative to the outer component, the side port of the inner component is accessible through the side opening of the outer component for providing transverse access to a guidewire. A first pressure sensor is disposed proximate of a distal end of the outer component and a second pressure sensor is disposed proximate of a distal end of the inner component, such that relative longitudinal translation between the inner and outer components permits a distance between the first and second pressure sensors to be varied.

Abstract: A selectively attachable and removable visual and tactile assessment tool or clip for use with a mobile device is provided. Clip is an elongate member forming a curvilinear shape having a magnifying lens at a distal end thereof. Clip has a transparent tubular member disposed between first and second openings through the body portion of the clip. Tubular member has varying internal diameters to simulate, for example, the constriction or stenosis of a patient's vessel lumen. Once clip is attached to mobile device and the magnifying lens is positioned over the camera of the mobile device, a catheter is inserted through tubular member. The magnifying lens enlarges the size of the catheter displayed on the screen of the mobile device.

Abstract: Embodiments hereof relate to methods and systems for determining a pressure gradient across a lesion of a vessel without requiring the use of a pharmacological hyperemic agent. A measurement system includes at least an injection catheter and a pressure-sensing instrument or guidewire slidingly disposed through the catheter, the pressure-sensing guidewire including at least one pressure sensor configured to obtain a pressure measurement for use in determining the pressure gradient across the lesion. The catheter is configured to deliver or inject a non-pharmacological fluid, such as saline or blood, across the lesion in order to increase a flow rate there-through, thereby simulating hyperemia without the use of a pharmacological hyperemic agent. Once an increased flow rate that simulates hyperemia is achieved, the pressure sensor of the pressure-sensing guidewire may be utilized to measure the pressure gradient across the lesion in order to assess the severity of the lesion.

Abstract: A delivery system for an implantable medical device includes a tool and a tethering member extending side-by-side within an inner shaft thereof; the tool extends within a first lumen, being in sliding engagement therein, and includes a distal end coupling feature that protrudes from a distal end of the inner shaft; and the tethering member has a first segment extending within a second lumen, and a second segment extending from the first segment and distally from the distal end of the inner shaft to an end of the tethering member, which is configured to engage with a holding member of the device, and with which the coupling feature of the tool is configured to couple. A retainer may be joined to another end of the tethering member that protrudes from a proximal port of the system.