Patents by Inventor Barry R. O'Keefe
Barry R. O'Keefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240002445Abstract: Disclosed is a class of knotted cyclic peptides. Related pharmaceutical compositions and methods of using the peptides and methods of synthesizing the peptides are also disclosed.Type: ApplicationFiled: November 17, 2021Publication date: January 4, 2024Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Barry R. O'Keefe, Lauren R. Haugh Krumpe, Yves Pommier, Christophe R. Marchand, Ingrid C. Schroeder, K. Johan Rosengren, Brice A.P. Wilson
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Publication number: 20230365633Abstract: The invention is directed to methods of treating or preventing a Rhabdoviridae virus infection in a mammal comprising administering griffithsin, or a fragment or mutant thereof, to the mammal.Type: ApplicationFiled: October 9, 2020Publication date: November 16, 2023Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, University of Louisville Research Foundation, Inc.Inventors: Nadia F. Gallardo-Romero, Barry R. O'Keefe, Kenneth E. Palmer
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Publication number: 20230218715Abstract: The present invention relates to griffithsin polypeptides and methods of using the same in inhibition of viral infection. Certain embodiments of the present invention relate to modified griffithsin polypeptides and methods of inhibiting coronavirus infection in a host by administering modified griffithsin polypeptides to the upper respiratory tract of the host. Further embodiments relate to an intranasal spray formulation including griffithsin polypeptides in a composition including a preservative and a viscosity modifier.Type: ApplicationFiled: May 18, 2021Publication date: July 13, 2023Inventors: Kenneth E. Palmer, Joshua L. Fuqua, Lisa Cencia Rohan, Lin Wang, Barry R. O'Keefe
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Publication number: 20220315629Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.Type: ApplicationFiled: April 19, 2022Publication date: October 6, 2022Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
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Publication number: 20220289798Abstract: Provided herein are GRFT variants and methods of using such GRFT variants. The GRFT variants described herein can be PEGylated, which significantly improves the pharmacokinetics and decreases the immunogenicity of the GFRT composition.Type: ApplicationFiled: September 10, 2020Publication date: September 15, 2022Applicants: University of Louisville Research Foundation, Inc., The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Joshua Fuqua, Krystal Hamorsky, Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer
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Patent number: 11339195Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.Type: GrantFiled: November 27, 2019Date of Patent: May 24, 2022Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
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Patent number: 11331370Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified lectins. Also disclosed are methods for making and using the compositions.Type: GrantFiled: November 6, 2018Date of Patent: May 17, 2022Assignees: The Population Council, Inc., The United States of AmericaInventors: Barry R. O'Keefe, Melissa Robbiani, José A. Fernández Romero
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Patent number: 11034736Abstract: An isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 1, 2, or 3, wherein the at least eight contiguous amino acids have anti-viral activity, as well as an isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 1, 2, or 3, wherein the at least eight contiguous amino acids have anti-viral activity, a vector comprising such an isolated and purified nucleic acid molecule, a host cell comprising the nucleic acid molecule, optionally in the form of a vector, a method of producing an antiviral polypeptide or conjugate thereof, the anti-viral polypeptide itself, a conjugate or fusion protein comprising the anti-viral polypeptide, and compositions comprising an effective amount of the anti-viral polypeptide or conjugate or fusion protein thereof. Further provided are methods of inhibiting prophylactically or therapeutically a viral infection of a host.Type: GrantFiled: January 9, 2015Date of Patent: June 15, 2021Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Barry R. O'Keefe, James B. McMahon, Koreen Ramessar, Chang-yun Xiong
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Publication number: 20200087359Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.Type: ApplicationFiled: November 27, 2019Publication date: March 19, 2020Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
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Patent number: 10501507Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.Type: GrantFiled: February 10, 2016Date of Patent: December 10, 2019Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Louisville Research Foundation, Inc., University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
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Publication number: 20190070253Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified lectins. Also disclosed are methods for making and using the compositions.Type: ApplicationFiled: November 6, 2018Publication date: March 7, 2019Applicants: The Population Council, Inc., The United States of AmericaInventors: Barry R. O'Keefe, Melissa Robbiani, José A. Fernández Romero
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Patent number: 10143721Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified lectins. Also disclosed are methods for making and using the compositions.Type: GrantFiled: January 13, 2015Date of Patent: December 4, 2018Assignees: The Population Council, Inc., The United States of America, as represented by the Secretary, Dept. of Health and Human ServicesInventors: Barry R. O'Keefe, Melissa Robbiani, José A. Fernández Romero
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Patent number: 9982025Abstract: The invention provides a construct containing two or more monomeric griffithsin molecules, optionally joined by a linker, as well as conjugate comprising the construct, a nucleic acid encoding the construct or conjugate, vectors, and cells. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.Type: GrantFiled: June 5, 2014Date of Patent: May 29, 2018Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Barry R. O'Keefe, Alexander Wlodawer, Tinoush Moulaei
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Publication number: 20180016307Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.Type: ApplicationFiled: February 10, 2016Publication date: January 18, 2018Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
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Publication number: 20160339076Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified lectins. Also disclosed are methods for making and using the compositions.Type: ApplicationFiled: January 13, 2015Publication date: November 24, 2016Applicants: The Population Council, Inc., The United States of AmericaInventors: Barry R. O'Keefe, Melissa Robbiani, José A. Fernández Romero
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Publication number: 20160333060Abstract: An isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 1, 2, or 3, wherein the at least eight contiguous amino acids have anti-viral activity, as well as an isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 1, 2, or 3, wherein the at least eight contiguous amino acids have anti-viral activity, a vector comprising such an isolated and purified nucleic acid molecule, a host cell comprising the nucleic acid molecule, optionally in the form of a vector, a method of producing an antiviral polypeptide or conjugate thereof, the anti-viral polypeptide itself, a conjugate or fusion protein comprising the anti-viral polypeptide, and compositions comprising an effective amount of the anti-viral polypeptide or conjugate or fusion protein thereof. Further provided are methods of inhibiting prophylactically or therapeutically a viral infection of a host.Type: ApplicationFiled: January 9, 2015Publication date: November 17, 2016Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER . . .Inventors: Barry R. O'Keefe, James B. McMahon, Koreen Ramessar, Chang-yun Xiong
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Publication number: 20160108097Abstract: The invention provides a construct containing two or more monomeric griffithsin molecules, optionally joined by a linker, as well as conjugate comprising the construct, a nucleic acid encoding the construct or conjugate, vectors, and cells. A nucleic acid encoding the polypeptide or fusion protein, as well as compositions or cells comprising the polypeptide, fusion protein, or nucleic acid also are provided.Type: ApplicationFiled: June 5, 2014Publication date: April 21, 2016Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Barry R. O'Keefe, Alexander Wlodawer, Tinoush Moulaei
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Patent number: 8481255Abstract: A scytovirin domain 1 (SD1) polypeptide, a nucleic acid encoding the polypeptide, and related fusion proteins, conjugates, isolated cells, vectors, and antibodies, as well as a method of inhibiting a viral infection using the same.Type: GrantFiled: September 30, 2011Date of Patent: July 9, 2013Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Barry R. O'Keefe, Chang-yun Xiong, James B. McMahon, Andrew Byrd
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Patent number: 8394764Abstract: An isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 3, wherein the at least eight contiguous amino acids have anti-viral activity, as well as an isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 3, wherein the at least eight contiguous amino acids have anti-viral activity, and, when the at least eight contiguous amino acids comprise amino acids 1-121 of SEQ ID NO: 3, the at least eight contiguous amino acids have been rendered glycosylation-resistant, a vector comprising such an isolated and purified nucleic acid molecule, a host cell comprising the nucleic acid molecule, optionally in the form of a vector, a method of producing an anti-viral polypeptide or conjugate thereof, the anti-viral polypeptide itself, a conjugate or fusion protein comprising the anti-viral polypeptide, and compositions comprising an effective amount of the anti-viralType: GrantFiled: February 7, 2011Date of Patent: March 12, 2013Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human ServicesInventors: Michael R. Boyd, Toshiyuki Mori, Barry R. O'Keefe
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Publication number: 20120053116Abstract: A scytovirin domain 1 (SD1) polypeptide, a nucleic acid encoding the polypeptide, and related fusion proteins, conjugates, isolated cells, vectors, and antibodies, as well as a method of inhibiting a viral infection using the same.Type: ApplicationFiled: September 30, 2011Publication date: March 1, 2012Applicant: The United States of America, as represented by the Secretary, Dept. of Health & Human ServicesInventors: Barry R. O'Keefe, Chang-yun Xiong, James B. McMahon, Andrew Byrd