Abstract: The present invention relates to an improved process for preparing [(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester—which compound is also known under its INN as darunavir—by reacting carbonic acid 2,5-dioxo-1-pyrrolidinyl [(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]ester with 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-benzenesulfonamide in ethanol as solvent. Furthermore said process allows for darunavir to be isolated immediately in its ethanolate form, i.e. darunavir monoethanolate, which is the marketed form of darunavir under the tradename Prezista™.

Abstract: The present invention relates to an improved process for preparing [(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester—which compound is also known under its INN as darunavir—by reacting carbonic acid 2,5-dioxo-1-pyrrolidinyl [(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]ester with 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-benzenesulfonamide in ethanol as solvent. Furthermore said process allows for darunavir to be isolated immediately in its ethanolate form, i.e. darunavir monoethanolate, which is the marketed form of darunavir under the tradename Prezista™.

Abstract: The present invention relates to an improved process for preparing [(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](2-methyl-propyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester—which compound is also known under its INN as darunavir—by reacting carbonic acid 2,5-dioxo-1-pyrrolidinyl[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]ester with 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-benzenesulfonamide in ethanol as solvent. Furthermore said process allows for darunavir to be isolated immediately in its ethanolate form, i.e. darunavir monoethanolate, which is the marketed form of darunavir under the tradename Prezista™.

Abstract: The present invention relates to an improved process for preparing [(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](2-methyl-propyl)amino]-2-hydroxy-1-(phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester—which compound is also known under its INN as darunavir—by reacting carbonic acid 2,5-dioxo-1-pyrrolidinyl[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]ester with 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-benzenesulfonamide in ethanol as solvent. Furthermore said process allows for darunavir to be isolated immediately in its ethanolate form, i.e. darunavir monoethanolate, which is the marketed form of darunavir under the tradename Prezista™.

Abstract: A coupling assembly for connection to a fluid supply is provided. The assembly comprises a socket portion having a first part connectable to the supply and a second part connectable to an elongate member; a sealing means retained by the socket portion; and a locking means for locking the socket portion to the elongate member; wherein the locking means comprises a moveable portion moveable between a first unlocked position and a second locked position by slideably moving the moveable portion relative to the socket portion such that the locking means engages with a complementary portion of the elongate member.

Abstract: A flow-through pressure regulator includes a retainer that secures a diaphragm relative to a seat, and includes a cylindrical portion, an axial end portion and an annular portion. The cylindrical portion extends about a longitudinal axis and is fixed with respect to the seat. The axial end portion extends from the cylindrical portion and extends generally orthogonal relative to the longitudinal axis. The axial end portion includes a plurality of apertures that permit fluid communication and are selected so as to reduce noise due to fluid flow.

Abstract: A pressure regulator includes a housing, a divider including a first valve member, and a second valve member. The housing includes an inlet and an outlet, and defines an interior volume. The divider separates the interior volume into first and second chambers, and included the first valve member, a diaphragm, and a retainer. The diaphragm extends between the housing and the first valve member. Fluid communication between the first and second chambers through the diaphragm being prevented. The retainer secures the diaphragm relative to the first valve member, and the retainer is press-fitted with respect to the first valve member. The second valve member is arranged between first and second configurations relative to the first valve member. The first configuration substantially prevents fluid communication between the inlet and the outlet, and the second configuration permits fluid communication between the inlet and the outlet.

Abstract: A flow-through pressure regulator includes a retainer that secures a diaphragm relative to a seat, and includes a cylindrical portion, an axial end portion and an annular portion. The cylindrical portion extends about a longitudinal axis and is fixed with respect to the seat. The axial end portion extends from the cylindrical portion and extends generally orthogonal relative to the longitudinal axis. The axial end portion includes a plurality of apertures that permit fluid communication and are selected so as to reduce noise due to fluid flow.

Abstract: A flow-through pressure regulator includes a retainer that secures a diaphragm relative to a seat, and includes a cylindrical portion, an axial end portion and an annular portion. The cylindrical portion extends about a longitudinal axis and is fixed with respect to the seat. The axial end portion extends from the cylindrical portion and extends generally orthogonal relative to the longitudinal axis. The axial end portion includes a plurality of apertures that permit fluid communication and are selected so as to reduce noise due to fluid flow.

Abstract: A pressure regulator includes a housing, a divider including a first valve member, and a second valve member. The housing includes an inlet and an outlet, and defines an interior volume. The divider separates the interior volume into first and second chambers, and included the first valve member, a diaphragm, and a retainer. The diaphragm extends between the housing and the first valve member. Fluid communication between the first and second chambers through the diaphragm being prevented. The retainer secures the diaphragm relative to the first valve member, and the retainer is press-fitted with respect to the first valve member. The second valve member is arranged between first and second configurations relative to the first valve member. The first configuration substantially prevents fluid communication between the inlet and the outlet, and the second configuration permits fluid communication between the inlet and the outlet.

Abstract: A flow-through pressure regulator includes a retainer that secures a diaphragm relative to a seat, and includes a cylindrical portion, an axial end portion and an annular portion. The cylindrical portion extends about a longitudinal axis and is fixed with respect to the seat. The axial end portion extends from the cylindrical portion and extends generally orthogonal relative to the longitudinal axis. The axial end portion includes a plurality of apertures that permit fluid communication and are selected so as to reduce noise due to fluid flow.

Abstract: The automotive fuel pump module includes a sealed housing containing a fuel reservoir and a fuel pump for mounting within the fuel tank of a vehicle. A flange is secured to the wall of the fuel tank and lies in communication with the outlet of the fuel pump by a pair of pivotally connected arms for flowing fuel from the reservoir within the housing to outside of the fuel tank and to the fuel rail. A torsion spring biases the arms such that the reservoir body is referenced to the bottom of the fuel tank from the flange of the module. A pressure regulator may be provided within the housing for returning excess fuel to the reservoir. A mounting cup includes a pocket for receiving a pin on the housing cover for vibrationally isolating the pump and housing from one another and preventing rotation of the pump relative to the housing.

Abstract: The returnless regulator includes a housing having a movable diaphragm defining a portion of a fuel regulating chamber. A normally open valve receives pressurized fuel from a fuel pump and lies in communication on its opposite side with the chamber. The diaphragm includes a projection engaging a valve element for moving the valve element away from its seat and enabling increased flow of fuel from the fuel pump through the valve into the chamber in response to fuel pressure in the chamber below a predetermined fuel regulation pressure and enabling the valve member for movement toward the valve seat, thereby enabling decreased flow of fuel from the fuel pump through the valve into the chamber in response to a fuel pressure in the chamber above the predetermined fuel regulation pressure. A retainer ring has recesses registering with openings in the lower housing part in communication with the chamber for flowing fuel to the fuel rail.

Abstract: A fluid communication device such as a fuel rail having a bellows damper positioned either in the end of the fuel rail or orthogonal to the axis of the fuel rail for dampening pulsed pressure waves from the flowing of the fuel. The bellows is a hollow tubular member having an enclosed end with a plurality of circular hollow ribs forming the outer surface of the bellows. The damper may also be located in a pocket or may be free floating in the fuel rail. An additional spring member is added to the damper for changing the spring rate characteristic of the bellows.

Abstract: The turbine assembly of a fuel pump includes a pair of housings having an impeller disposed between the housings with a minimum clearance. In a first form, there is provided a spacer between the housings which can be crushed between a pair of press platens such that the combined depth of the spacer and recess in one of the housings receiving the impeller equals the depth of the impeller and the minimum clearance. In another form, the housings may be precisely located and laser-welded one to the other to provide the minimum clearance between the impeller and housings. In a third form, an annular spacer is disposed between the flat faces of the opposed housings and crushed to a predetermined depth such that the spacer depth equals the depth of the impeller and the minimum clearance.