Patents by Inventor Barry S. Schonwetter

Barry S. Schonwetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inducible defensin peptide from mammalian epithelia
    Patent number: 5849490
    Abstract: The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of LAP are also provided. The present invention also relates to cDNA encoding LAP, the prepro- precursor or the pro-lingual precursor. In addition, methods of treating microbial infection of the epithelia are provided. Such infections can be treated by contacting the epithelia with an antimicrobially effective amount of a purified mammalian epithelial LAP or by administering a component which cause endogenous production or up-regulation of LAP.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: December 15, 1998
    Assignee: Magainin Pharmaceuticals, Inc.
    Inventors: Barry S. Schonwetter, Michael A. Zasloff
  • Inducible defensin peptide from mammalian epithelia
    Patent number: 5656738
    Abstract: The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of LAP are also provided. The present invention also relates to cDNA encoding LAP, the prepro- precursor or the pro-lingual precursor. In addition, methods of treating microbial infection of the epithelia are provided. Such infections can be treated by contacting the epithelia with an antimicrobially effective amount of a purified mammalian epithelial LAP or by administering a component which cause endogenous production or up-regulation of LAP.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: August 12, 1997
    Assignee: Magainin Pharmaceuticals, Inc.
    Inventors: Barry S. Schonwetter, Michael A. Zasloff
  • Inducible defensin peptide from mammalian epithelia
    Patent number: 5550109
    Abstract: The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of LAP are also provided. The present invention also relates to cDNA encoding LAP, the prepro- precursor or the pro-lingual precursor. In addition, methods of treating microbial infection of the epithelia are provided. Such infections can be treated by contacting the epithelia with an antimicrobially effective amount of a purified mammalian epithelial LAP or by administering a component which cause endogenous production or up-regulation of LAP.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: August 27, 1996
    Assignee: Magainin Pharmaceuticals Inc.
    Inventors: Barry S. Schonwetter, Michael A. Zasloff