Abstract: An improved scraping edge for use on a plow blade employing at least one resilient scraping edge section for contact with a surface to be plowed and mounting holes to attach the scraping edge section to the plow blade.

Abstract: An improved material pusher or containment plow employing a floating vehicle-coupling system, a wear shoe, as well as a plurality of removable scraping edge sections.

Abstract: An improved material pusher or containment plow employing a floating vehicle-coupling system, a modular composite scraping edge, a front-pivoting wear shoe with an adjustable angle, as well as water-shedding features. The disclosed containment plow and features are provide improved the surface outcome under various snow and ice conditions.

Abstract: An improved material pusher or containment plow employing a floating vehicle coupling system, a modular composite scraping edge, a front-pivoting wear shoe with an adjustable angle, as well as water-shedding features. The disclosed containment plow and features provide improved the surface outcomes under various snow and ice conditions.

Abstract: An improved material pusher or containment plow employing a floating vehicle-coupling system, a modular composite scraping edge, a front-pivoting wear shoe with an adjustable angle, as well as water-shedding features. The disclosed containment plow and features are provide improved the surface outcome under various snow and ice conditions.

Abstract: An improved material pusher or containment plow employing a floating vehicle-coupling system, a modular composite scraping edge, a front-pivoting wear shoe with an adjustable angle, as well as water-shedding features. The disclosed containment plow and features are provide improved the surface outcome under various snow and ice conditions.

Abstract: An improved material pusher or containment plow employing a floating vehicle-coupling system, a modular composite scraping edge, a front-pivoting wear shoe with an adjustable angle, as well as water-shedding features.

Abstract: An improved material pusher or containment plow employing a floating vehicle-coupling system, a modular composite scraping edge, a front-pivoting wear shoe with an adjustable angle, as well as water-shedding features. The disclosed containment plow and features are provide improved the surface outcome under various snow and ice conditions.

Abstract: An improved material pusher or containment plow employing a floating vehicle-coupling system, a modular composite scraping edge, a front-pivoting wear shoe with an adjustable angle, as well as water-shedding features. The disclosed containment plow and features are provide improved the surface outcome under various snow and ice conditions.

Abstract: An improved material pusher or containment plow employing a floating vehicle-coupling system, a modular composite scraping edge, a front-pivoting wear shoe with an adjustable angle, as well as water-shedding features. The disclosed containment plow and features are provide improved the surface outcome under various snow and ice conditions.

Abstract: A divot repair apparatus transports and dispenses fill material to fill and repair divots. The repair apparatus includes a hopper for holding the fill material, the hopper being adapted to be worn on the user's back; a conduit for dispensing the fill material from the hopper; and a valve assembly disposed in the conduit for controlling the flow of the fill material from the hopper. An outlet end of the conduit may include a smoothing tool for manipulating the fill material after it has been dispensed.

Abstract: A divot repair apparatus transports and dispenses fill material to fill and repair divots. The repair apparatus includes a hopper for holding the fill material, the hopper being adapted to be worn on the user's back; a conduit for dispensing the fill material from the hopper; and a valve assembly disposed in the conduit for controlling the flow of the fill material from the hopper. An outlet end of the conduit may include a smoothing tool for manipulating the fill material after it has been dispensed.

Abstract: A material pushing apparatus is disclosed that has a central blade, at least one removable side plate attached to the central blade and a segmented scraping edge flexibly attached to the central blade along the bottom longitudinal edge of the blade. A position sensor is attached between the blade and the scraping edge and produces a position signal that is displayed to indicate the relative position between the blade and edge in order to characterize the amount of downward pressure applied to the scraping edge. Other aspects and features of the disclosed apparatus include a tilt sensor and display, and an improved coupler having shock-absorbing features and a cam-type clamping arrangement.

Abstract: The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.

Abstract: The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.

Abstract: The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.

Abstract: In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the invention provides a method of treating cancer comprising administering to a subject a combination of topoisomerase inhibitor and PARP inhibitor. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase and a topoisomerase, as well as providing formulations and modes of administering such compositions.

Abstract: The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.

Abstract: The present invention provides compositions of matter, kits, and methods for use in treating cancer and viral conditions. In particular the invention provides for pharmaceutical compositions containing nitrobenzamide compounds that have enhanced solubility in aqueous solutions.

Abstract: The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.