Abstract: The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises a) a thermal conversion step of holding the composition comprising the antibody molecule at a temperature in the range 30 to 60° C. for a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: A technique comprising: providing an assembly temporarily adhered on opposite sides to respective carriers by respective adhesive elements, the assembly including at least one plastic support sheet; heating the assembly while mechanically compressing the assembly between the carriers, wherein the strength of adhesion of one of said adhesive elements to the respective carrier and/or to the assembly is partially reduced during said heating of the assembly under mechanical compression; and wherein the strength of adhesion of the said adhesive element to the carrier and/or to the assembly is further reducible by further heating the said adhesive element after partially or completely relaxing the pressure at which the assembly is mechanically compressed between the two carriers.

Abstract: A technique of producing a liquid crystal device, comprising: providing a cell assembly comprising a liquid crystal material contained directly between (i) a polariser component comprising an active film and no more than one support film, and (ii) a first control component including a stack of layers defining electrical control circuitry; and containing further liquid crystal material directly between the polariser component of the assembly and another control component including another stack of layers defining electrical control circuitry.

Abstract: A liquid crystal (LC) device comprising a stack of at least first and second LC cells in optical series, each of the first and second LC cells comprising two half-cells and LC material contained in a space at least partially defined by spacer structures forming an integral part of one or both half-cells; wherein the arrangement within an active area of the device of the spacer structures in one of the first and second LC cells is different to the arrangement within the active area of the device of the spacer structures in the other of the first and second LC cells; and wherein the difference between the two arrangements comprises an ordered aspect.

Abstract: A technique, comprising: removing a protective film from one side of a polarisation filter component to expose a dichroic doped polymer active film or a layer formed in situ on the dichroic doped polymer active film; and thereafter forming in situ on the side of the polarisation filter component one or more functional layers of a liquid crystal device.

Abstract: A liquid crystal cell comprising liquid crystal material contained between two plastics film components, wherein the liquid crystal material is interspersed with spacers, wherein (a) the area occupied by spacers is between about 0.25% and about 0.5% of the sum of (a) the area occupied by spacers and (b) the area occupied by the liquid crystal material.

Abstract: A device, comprising: a liquid crystal cell comprising liquid crystal material; a stack of layers, including one or more organic polymer semiconductor layers, for electrically controlling one or more optical properties of the liquid crystal material; first and second air species barriers between which both said liquid crystal material and said one or more organic polymer semiconductor layers are located; and a third air species barrier between said liquid crystal material and said one or more organic polymer semiconductor layers; wherein the first and second air species barriers exhibit substantially different transmission rates under the same conditions for at least one air species.

Abstract: The present invention provides a method for recovering a human VH3 domain-containing antibody in monomeric form. In particular the present invention provides a new method that allows recovery of monomeric human VH3 domain-containing antibodies from a mixture containing monomeric and multimeric forms of the antibody.

Abstract: A technique of producing a liquid crystal device, comprising: providing a cell assembly comprising a liquid crystal material contained directly between (i) a polariser component comprising an active film and no more than one support film, and (ii) a first control component including a stack of layers defining electrical control circuitry; and containing further liquid crystal material directly between the polariser component of the assembly and another control component including another stack of layers defining electrical control circuitry.

Abstract: A technique, comprising: removing a protective film from one side of a polarisation filter component to expose a dichroic doped polymer active film or a layer formed in situ on the dichroic doped polymer active film; and thereafter forming in situ on the side of the polarisation filter component one or more functional layers of a liquid crystal device.

Abstract: The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises a) a thermal conversion step of holding the composition comprising the antibody molecule at a temperature in the range 30 to 60° C. for a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: A technique, comprising: assembling together two liquid crystal half-cells; wherein at least one of the two half-cells comprises a support film and an array of spacer structures formed in situ on the support film; and wherein the assembling comprises pressing together the two half-cells with pre-prepared spacer elements dispensed onto at least one of the two half-cells over at least an area shared with the array of spacer structures; wherein the spacer elements provide primary control of the size of a cell gap between the two half-cells, and the spacer structures function to resist compression of the spacer elements.

Abstract: The present invention provides a method for recovering a human VH3 domain-containing antibody in monomeric form. In particular the present invention provides a new method that allows recovery of monomeric human VH3 domain-containing antibodies from a mixture containing monomeric and multimeric forms of the antibody.

Abstract: A liquid crystal (LC) device comprising a stack of at least first and second LC cells in optical series, each of the first and second LC cells comprising two half-cells and LC material contained in a space at least partially defined by spacer structures forming an integral part of one or both half-cells; wherein the arrangement within an active area of the device of the spacer structures in one of the first and second LC cells is different to the arrangement within the active area of the device of the spacer structures in the other of the first and second LC cells; and wherein the difference between the two arrangements comprises an ordered aspect.

Abstract: The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises a) a thermal conversion step of holding the composition comprising the antibody molecule at a temperature in the range 30 to 60° C. for a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: A display device for conformal mounting on a curved surface inclined at an oblique angle relative to a horizontal plane, the display device comprising: a plurality of pixels, a first set of conductive lines connected to the plurality of pixels; and a second set of conductive lines connected to the plurality of pixels, wherein the first set of conductive lines and the second set of conductive lines are arranged to define a shape of each of the plurality of pixels such that the pixels appear, to a viewer, to extend at least one of horizontally or vertically across the display device when the display device is mounted on the curved surface.

Abstract: A technique comprising: providing an assembly temporarily adhered on opposite sides to respective carriers by respective adhesive elements, the assembly including at least one plastic support sheet; heating the assembly while mechanically compressing the assembly between the carriers, wherein the strength of adhesion of one of said adhesive elements to the respective carrier and/or to the assembly is partially reduced during said heating of the assembly under mechanical compression; and wherein the strength of adhesion of the said adhesive element to the carrier and/or to the assembly is further reducible by further heating the said adhesive element after partially or completely relaxing the pressure at which the assembly is mechanically compressed between the two carriers.