Abstract: A plunger device for a hydrocarbon wellbore is provided that has replaceable modular components that allow the function of the plunger device to be altered. Concentric sleeves and short sleeves may be selectively disposed about a chassis of the plunger device. One or more short sleeves may be removed to expose an entrance aperture which allows fluid flow to enter an interior volume of the chassis and pass through an exit aperture in the chassis. This configuration allows the plunger to descend down a bore hole more rapidly. However, a well operator may determine that it is advantageous to keep the short sleeve on the chassis to block the entrance aperture. Thus, the weight of the plunger overcomes the pressure in the borehole, and the plunger descends more slowly down the borehole.

Abstract: A method for increasing the molecular diversity of polyketides and non-ribosomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding the polyketide or peptide.

Abstract: A plunger device for a hydrocarbon wellbore is provided that has replaceable modular components that allow the function of the plunger device to be altered. Concentric sleeves and short sleeves may be selectively disposed about a chassis of the plunger device. One or more short sleeves may be removed to expose an entrance aperture which allows fluid flow to enter an interior volume of the chassis and pass through an exit aperture in the chassis. This configuration allows the plunger to descend down a bore hole more rapidly. However, a well operator may determine that it is advantageous to keep the short sleeve on the chassis to block the entrance aperture. Thus, the weight of the plunger overcomes the pressure in the borehole, and the plunger descends more slowly down the borehole.

Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Abstract: There is provided inter alia a compound of formula (I) or a pharmaceutically acceptable salt thereof and its use in therapy.

Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.

Abstract: There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: There are provided inter alia compounds of formula (I) useful as cyclophilin inhibitors.

Abstract: There is provided inter alia a compound of formula (I) or a pharmaceutically acceptable salt thereof and its use in therapy.

Abstract: There is provided inter alia a compound of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.

Abstract: There is provided inter alia compounds of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.

Abstract: There are provided inter alia compounds of formula (I) useful as cyclophilin inhibitors.

Abstract: There is provided inter alia a compound of formula (I): for use in treatment of viral infection or as an immunosuppressant.

Abstract: The present invention relates to 39-desmethoxyrapamycin derivatives and their uses thereof. The present invention provides for the use of these compounds in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.

Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.

Abstract: The present invention relates to 4,5-dihydromacbecin analogues to the formula (IA) or (IB), or a pharmaceutically acceptable salt there of: wherein: R1 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.

Abstract: The present invention relates to novel 39-desmethoxy-39-methylrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxy-39 -methylrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.