Patents by Inventor Bart Antonius NIJMEIJER

Bart Antonius NIJMEIJER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTERNALIZING BINDING MOLECULES
    Publication number: 20240325562
    Abstract: The invention relates to the field of binding molecules comprising at least one single variable antibody domain, targeted at receptors present on fibrogenic effector cells, such as activated hepatic stellate cells in liver fibrosis, activated interstitial fibroblasts or vascular smooth muscle cells in lung fibrosis, activated mesangial- or interstitial fibroblasts in renal fibrosis, activated dermal fibroblasts in systemic sclerosis/scleroderma, activated fibroblasts in inflammatory bowel disease, or tumor-supporting stromal fibroblasts in sclerosing malignant tumors. More in particular, the invention relates to internalizing binding molecules for cell-specific targeted delivery of anti-fibrotic substances. The invention also relates to a binding molecule comprising at least two single variable antibody domains, each targeting a receptor on said fibrogenic effector cells.
    Type: Application
    Filed: September 15, 2021
    Publication date: October 3, 2024
    Applicant: LinXis B.V.
    Inventors: Bart Antonius NIJMEIJER, Paulus Martinus Petrus VAN BERGEN EN HENEGOUWEN, Niels Jurriaan SIJBRANDI, Eugen MERKUL, Joey Armand MUNS, Jan Hendrik SCHOOTEN, Sebas Daniel PRONK
  • MEANS AND METHODS FOR AAV GENE THERAPY IN HUMANS
    Publication number: 20220395545
    Abstract: The present invention relates to means and method for AAV based gene therapies in humans. In particular, the present invention relates to the treatment of human patients that may be suspected to have antibodies directed against the AAV intended for use in the treatment.
    Type: Application
    Filed: June 30, 2022
    Publication date: December 15, 2022
    Applicant: uniQure IP B.V.
    Inventors: Bart Antonius NIJMEIJER, Valerie FERREIRA
  • MEANS AND METHODS FOR AAV GENE THERAPY IN HUMANS
    Publication number: 20190008909
    Abstract: The present invention relates to means and method for AAV based gene therapies in humans. In particular, the present invention relates to the treatment of human patients that may be suspected to have antibodies directed against the AAV intended for use in the treatment.
    Type: Application
    Filed: July 10, 2018
    Publication date: January 10, 2019
    Applicant: uniQure IP B.V.
    Inventors: Bart Antonius NIJMEIJER, Valerie FERREIRA