Patents by Inventor Bart Hazes

Bart Hazes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pseudomonas treatment composition and method
    Patent number: 6767545
    Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: July 27, 2004
    Assignee: Governors of the University of Alberta
    Inventors: Randall T. Irvin, Randy J. Read, Bart Hazes, Wah Y. Wong, Sastry A. Parimi, Linda M. G. Glasier
  • Pseudomonas treatment composition and method
    Publication number: 20020098196
    Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.
    Type: Application
    Filed: May 24, 2001
    Publication date: July 25, 2002
    Inventors: Randall T. Irvin, Randy J. Read, Bart Hazes, Wah Y. Wong, Sastry A. Parimi, Linda M. G. Glasier
  • Pseudomonas treatment composition and method
    Patent number: 6342233
    Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: January 29, 2002
    Assignee: Governors of the University of Alberta
    Inventors: Randall T. Irvin, Randy J. Read, Bart Hazes, Wah Y. Wong, Sastry A. Parimi, Linda M. G. Glasier
  • Modification of pertussis toxin
    Patent number: 6168928
    Abstract: The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: January 2, 2001
    Assignee: Connaught Laboratories Limited
    Inventors: Randy J. Read, Penelope E. Stein, Stephen A. Cockle, Raymond P. Oomen, Sheena Loosmore, Michel H. Klein, Glen D. Armstrong, Bart Hazes
  • Modification of pertussis toxin
    Patent number: 6018022
    Abstract: The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 25, 2000
    Assignees: Connaught Laboratories Limited, University of Alberta
    Inventors: Randy J. Read, Penelope E. Stein, Stephen A. Cockle, Raymond P. Oomen, Sheena Loosmore, Michel H. Klein, Glen D. Armstrong, Bart Hazes
  • Modification of pertussis toxin
    Patent number: 5977304
    Abstract: The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 2, 1999
    Assignees: Connaught Laboratories Limited, University of Alberta
    Inventors: Randy J. Read, Penelope E. Stein, Stephen A. Cockle, Raymond P. Oomen, Sheena Loosmore, Michel H. Klein, Glen D. Armstrong, Bart Hazes
  • Modification of pertussis toxin
    Patent number: 5965385
    Abstract: The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 12, 1999
    Assignees: Connaught Laboratories Limited, University of Alberta
    Inventors: Randy J. Read, Penelope E. Stein, Stephen A. Cockle, Raymond P. Oomen, Sheena Loosmore, Michel H. Klein, Glen D. Armstrong, Bart Hazes
  • Modification of pertussis toxin
    Patent number: 5856122
    Abstract: The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: January 5, 1999
    Assignee: University of Alberta
    Inventors: Randy J. Read, Penelope E. Stein, Stephen A. Cockle, Raymond P. Oomen, Sheena Loosmore, Michel H. Klein, Glen D. Armstrong, Bart Hazes