Patents by Inventor Bart Marinus Engels

Bart Marinus Engels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Self-immolative plasmid backbone
    Patent number: 11959069
    Abstract: The invention relates to a method for separating a polynucleotide insert from a polynucleotide vector backbone. The backbone has a plurality of cleavage sites distributed such that the backbone is converted into fragments when the sites are cleaved. This allows straightforward separation of the insert from the backbone. The invention also relates to backbones for use in such a method, and to plasmids and kits comprising such backbones.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: April 16, 2024
    Assignee: ProteoNic Biotechnology IP B.V.
    Inventors: Bart Marinus Engels, Raymond Michael Dimphena Verhaert, Maurice Wilhelmus Van der Heijden
  • CONSTRUCT AND SEQUENCE FOR ENHANCED GENE EXPRESSION
    Publication number: 20220282261
    Abstract: The invention relates to a method for transcription and expression using a nucleic acid construct which is characterized by the presence of a promoter followed by an intronic promoter. The invention further relates to said nucleic acid construct, an expression vector and a cell comprising said construct, and its use. The invention also relates to methods for transcription and optionally expression using a nucleotide sequence. The invention further relates to said nucleotide sequence and a construct, expression vector and cell comprising said nucleotide sequence, and its use.
    Type: Application
    Filed: May 20, 2022
    Publication date: September 8, 2022
    Inventors: Maurice Wilhelmus van der Heijden, Bart Marinus Engels
  • Self-immolative plasmid backbone
    Publication number: 20220154166
    Abstract: The invention relates to a method for separating a polynucleotide insert from a polynucleotide vector backbone. The backbone has a plurality of cleavage sites distributed such that the backbone is converted into fragments when the sites are cleaved. This allows straightforward separation of the insert from the backbone. The invention also relates to backbones for use in such a method, and to plasmids and kits comprising such backbones.
    Type: Application
    Filed: February 28, 2020
    Publication date: May 19, 2022
    Applicant: ProteoNic Biotechnology IP B.V.
    Inventors: Bart Marinus Engels, Raymond Michael Dimphena Verhaert, Maurice Wilhelmus Van der Heijden
  • Construct and Sequence for Enhanced Gene Expression
    Publication number: 20210198677
    Abstract: The invention relates to a method for transcription and expression using a nucleic acid construct which is characterized by the presence of a promoter followed by an intronic promoter. The invention further relates to said nucleic acid construct, an expression vector and a cell comprising said construct, and its use. The invention also relates to methods for transcription and optionally expression using a nucleotide sequence. The invention further relates to said nucleotide sequence and a construct, expression vector and cell comprising said nucleotide sequence, and its use.
    Type: Application
    Filed: January 11, 2021
    Publication date: July 1, 2021
    Inventors: Maurice Wilhelmus van der Heijden, Bart Marinus Engels
  • Construct and sequence for enhanced gene expression
    Patent number: 10889822
    Abstract: The invention relates to a method for transcription and expression using a nucleic acid construct which is characterized by the presence of a promoter followed by an intronic promoter. The invention further relates to the nucleic acid construct, an expression vector and a cell comprising the construct, and its use. The invention also relates to methods for transcription and optionally expression using a nucleotide sequence. The invention further relates to the nucleotide sequence and a construct, expression vector and cell comprising the nucleotide sequence, and its use.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: January 12, 2021
    Inventors: Maurice Wilhelmus van der Heijden, Bart Marinus Engels
  • Construct and Sequence for Enhanced Gene Expression
    Publication number: 20170029826
    Abstract: The invention relates to a method for transcription and expression using a nucleic acid construct which is characterized by the presence of a promoter followed by an intronic promoter. The invention further relates to said nucleic acid construct, an expression vector and a cell comprising said construct, and its use. The invention also relates to methods for transcription and optionally expression using a nucleotide sequence. The invention further relates to said nucleotide sequence and a construct, expression vector and cell comprising said nucleotide sequence, and its use.
    Type: Application
    Filed: December 24, 2014
    Publication date: February 2, 2017
    Inventors: Maurice Wilhelmus van der Heijden, Bart Marinus Engels