Abstract: The current invention concerns a device for the topical cryotherapy of dermatological disorders, the device comprising: a housing for holding a pressurized carbon dioxide cartridge; an applicator nozzle comprising (i) an internal channel for guiding the outflow of carbon dioxide from said pressurized carbon dioxide cartridge, and (ii) an applicator surface onto which carbon dioxide ice may be formed; and an actuator mechanism for controlling an outflow of carbon dioxide from said pressurized carbon dioxide cartridge to said applicator nozzle. The invention further concerns a cryogenic applicator pen comprising an actuator assembly for controlling an outflow of a cryogenic fluid, wherein said actuator assembly comprises at least one spring leaf, wherein said spring leaf on one side bears against a ball of a ball valve and on an opposite side bears against a positioning casing bearing a needle for piercing a cryogenic fluid cartridge.

Abstract: The current invention relates to a soft gummy for therapeutic oral use, said soft gummy comprising an outer shell encapsulating an inner liquid, wherein said outer shell comprises: (i) a pectin; and (ii) honey in an amount of at least 25 wt. % relative to the weight of the outer shell; wherein said inner liquid has a moisture content of at least 10 wt. % as measured by ISO 760:1978 and a viscosity of at most 50.0 Pa s measured at 20° C. and wherein the soft gummy comprises a hydrolysable tannin or source of hydrolysable tannin. The invention also relates to a use of a soft gummy.

Abstract: The current invention relates to a Method for extracting phenolic aldehydes from a lignocellulosic biomass comprising the steps of: (i) mechanochemically reacting said lignocellulosic biomass with a dry base, thereby agglomerating said lignocellulosic biomass with said dry base under pressure to form agglomerated bodies; and (ii) oxidative processing of the agglomerated bodies, comprising the step of boiling said agglomerated bodies for a period of time sufficient to extract phenolic aldehydes from said agglomerated bodies, wherein said lignocellulosic biomass is derivable from one or more herbaceous crops, and wherein said dry base is a dry inorganic oxide, a dry inorganic hydroxide, or a mixture thereof.

Abstract: The current invention relates to a soft gummy for oral use, said soft gummy comprises an outer shell encapsulating an inner liquid, wherein said outer shell comprises 0.5-25 wt. % of a pectin relative to the weight of the outer shell and has a viscosity of 25-1000 Pa s measured at 20° C. and wherein said inner liquid has a moisture content of 5-99 wt. % as measured by ISO 760:1978 and a viscosity of 0.01-20 Pa s measured at 20° C.

Abstract: The current invention relates to a soft gummy for therapeutic oral use, said soft gummy comprising an outer shell encapsulating an inner liquid, wherein said outer shell comprises: (i) a pectin; and (ii) honey in an amount of at least 25 wt. % relative to the weight of the outer shell; wherein said inner liquid has a moisture content of at least 10 wt. % as measured by ISO 760:1978 and a viscosity of at most 50.0 Pa s measured at 20° C., and wherein the soft gummy comprises a hydrolysable tannin or source of hydrolysable tannin. The invention also relates to a use of a soft gummy.

Abstract: The current invention relates to a composition comprising: beeswax, hemisqualane, an emulsifier and at least one vegetable oil, for use in treatment of infection by lice. The invention further relates to a use of said composition for the treatment of infection by lice.

Abstract: The present invention provides and oral dosage form comprising a granular phase and a non-granular phase, whereby the granular phase is comprised of a therapeutically effective amount of pharmaceutically active agent, a gas forming agent and a hydrophilic polymer. Such dosages are found to provide fast dissolution rates for ingredients having low solubility in water. In addition, the present invention provides a method of preparation thereof.

Abstract: The current invention relates to a soft gummy for therapeutic oral use, said soft gummy comprising an outer shell encapsulating an inner liquid, wherein said outer shell comprises: (i) a pectin; and (ii) honey in an amount of at least 25 wt. % relative to the weight of the outer shell; wherein said inner liquid has a moisture content of at least 10 wt. % as measured by ISO 760:1978 and a viscosity of at most 50.0 Pa s measured at 20° C., and wherein the soft gummy comprises a hydrolysable tannin or source of hydrolysable tannin. The invention also relates to a use of a soft gummy.

Abstract: The present invention provides a liquid nail lacquer composition comprising a pharmaceutically active compound and an aqueous polymer dispersion, wherein said liquid nail lacquer composition forms a film upon drying under standard ambient temperature and pressure; a method for providing the same; and a container comprising said liquid nail lacquer composition.

Abstract: The present invention relates to a pen for the treatment of dermatological disorders, such as warts and the like, by means of a coolant. The pen includes a distal part having a holder for the storage of a coolant and a proximal part with an applicator for the administration of the coolant to the dermatological surface for treatment. These parts extend axially and are in coolant communication by means of a coolant passage in the proximal part, in which a valve body is provided for closing off and/or opening the passage. The passage is provided with at least one bypass for the coolant. In addition, the invention relates to a method for the administration of the pen.

Abstract: The present invention relates to a composition for killing arthropods and their eggs, such as lice or ticks and nits. More in particular, the invention provides a composition for killing arthropods, said composition comprising at least 65% by weight of a mixture of saturated linear or branched hydrocarbons, wherein said hydrocarbons comprise a mixture of saturated linear or branched C10-C16 hydrocarbons and saturated linear or branched C17-C25 hydrocarbons, wherein the ratio of saturated linear or branched C10-C16 hydrocarbons to saturated linear or branched C17-C25 hydrocarbons by weight is lower than 15:85. The invention further relates to the use of such composition for killing arthropods and to a method for killing arthropods comprising the application of the present composition.

Abstract: The present invention relates to a composition for killing arthropods and their eggs, such as lice or ticks and nits. More in particular, the invention provides a composition for killing arthropods, said composition comprising at least 65% by weight of a mixture of saturated linear or branched hydrocarbons, wherein said hydrocarbons comprise a mixture of saturated linear or branched C10-C16 hydrocarbons and saturated linear or branched C17-C25 hydrocarbons, wherein the ratio of saturated linear or branched C10-C16 hydrocarbons to saturated linear or branched C17-C25 hydrocarbons by weight is lower than 15:85. The invention further relates to the use of such composition for killing arthropods and to a method for killing arthropods comprising the application of the present composition.

Abstract: The current invention concerns a device for the topical cryotherapy of dermatological disorders, the device comprising: a housing for holding a pressurized carbon dioxide cartridge; an applicator nozzle comprising (i) an internal channel for guiding the outflow of carbon dioxide from said pressurized carbon dioxide cartridge, and (ii) an applicator surface onto which carbon dioxide ice may be formed; and an actuator mechanism for controlling an outflow of carbon dioxide from said pressurized carbon dioxide cartridge to said applicator nozzle. The invention further concerns a cryogenic applicator pen comprising an actuator assembly for controlling an outflow of a cryogenic fluid, wherein said actuator assembly comprises at least one spring leaf, wherein said spring leaf on one side bears against a ball of a ball valve and on an opposite side bears against a positioning casing bearing a needle for piercing a cryogenic fluid cartridge.

Abstract: The present invention provides a liquid composition comprising a pharmaceutically active compound and an aqueous polymer dispersion, wherein said liquid composition forms a film upon drying under standard ambient temperature and pressure; a method for providing the same; and a container comprising said liquid composition.

Abstract: Compositions for the topical treatment of fungal infections in nails, comprising at least one physiologically acceptable carboxylic acid capable of reducing the pH in keratinous tissue, in particular nails, of a treated person below 4.0, preferably in the range of 1.5-4.0, a physiologically acceptable carrier comprising at least one C1-C4 alkyl ester of lactic acid, and at least one physiologically acceptable fluorescent whitening agent. The invention relates to the use of said composition for the preparation of a product suitable for treatment of fungal infections. The invention also relates to the use of said composition for the treatment of a fungal infection.

Abstract: The present disclosure provides silylated polyalcohols, compositions thereof and their use as medical, insecticidal, prophylactic or therapeutic substances for the treatment or prevention of infection or infestation by arthropods. More specifically, the disclosure relates to the methods of treatment of infections or infestation by lice in a human comprising administration of an effective amount of silylated polyalcohols and compositions thereof.

Abstract: The present invention provides a liquid nail lacquer composition comprising a pharmaceutically active compound and an aqueous polymer dispersion, wherein said liquid nail lacquer composition forms a film upon drying under standard ambient temperature and pressure; a method for providing the same; and a container comprising said liquid nail lacquer composition.

Abstract: The present invention provides a liquid composition comprising a pharmaceutically active compound and an aqueous polymer dispersion, wherein said liquid composition forms a film upon drying under standard ambient temperature and pressure; a method for providing the same; and a container comprising said liquid composition.

Abstract: The present disclosure provides silylated polyalcohols, compositions thereof and their use as medical, insecticidal, prophylactic or therapeutic substances for the treatment or prevention of infection or infestation by arthropods. More specifically, the disclosure relates to the methods of treatment of infections or infestation by lice in a human comprising administration of an effective amount of silylated polyalcohols and compositions thereof.

Abstract: The present invention provides and oral dosage form comprising a granular phase and a non-granular phase, whereby said granular phase is comprised of a therapeutically effective amount of pharmaceutically active agent, a gas forming agent and a hydrophilic polymer. Such dosages are found to provide fast dissolution rates for ingredients having low solubility in water. In addition, the present invention provides a method of preparation thereof.