Patents by Inventor Bart Walcarius

Bart Walcarius has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE PRODUCTION OF IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20200392214
    Abstract: The present invention relates to an improved method for the manufacture of immunoglobulin single variable domains. More specifically, the present invention relates to a method of producing immunoglobulin single variable domains in which the proportion of carbamylated variants is strongly reduced or absent and to improved immunoglobulin single variable domains obtainable by methods of the present invention.
    Type: Application
    Filed: August 2, 2019
    Publication date: December 17, 2020
    Applicant: Ablynx N.V.
    Inventors: Ann Brige, Bart Walcarius, Yves Meyvis, Mauro Sergi
  • METHOD FOR THE PRODUCTION OF IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20200062834
    Abstract: The present invention relates to an improved method for the manufacture of immunoglobulin single variable domains. More specifically, the present invention relates to a method of producing immunoglobulin single variable domains in which the proportion of carbamylated variants is strongly reduced or absent and to improved immunoglobulin single variable domains obtainable by methods of the present invention.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 27, 2020
    Applicant: Ablynx N.V.
    Inventors: Ann Brige, Bart Walcarius, Yves Meyvis, Mauro Sergi
  • Method for the production of immunoglobulin single variable domains
    Patent number: 9534039
    Abstract: Methods are provided for the expression of immunoglobulin variable domains that are secreted into the culture medium. The methods provide for the production of homogeneous immunoglobulin variable domains in which the proportion of product-related variants that comprise, at the N-terminus, at least one redundant amino acid residue derived from the secretion signal is strongly reduced or absent.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: January 3, 2017
    Assignee: Ablynx N.V.
    Inventors: Ann Brigé, Peter Schotte, Bart Walcarius
  • METHOD FOR THE PRODUCTION OF IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20140141507
    Abstract: Methods are provided for the expression of immunoglobulin variable domains that are secreted into the culture medium. The methods provide for the production of homogeneous immunoglobulin variable domains in which the proportion of product-related variants that comprise, at the N-terminus, at least one redundant amino acid residue derived from the secretion signal is strongly reduced or absent.
    Type: Application
    Filed: May 9, 2012
    Publication date: May 22, 2014
    Applicant: Ablynx N.V.
    Inventors: Ann Brigé, Peter Schotte, Bart Walcarius
  • METHOD FOR THE PRODUCTION OF IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20130261288
    Abstract: The present disclosure relates to an improved method for the manufacture of immunoglobulin single variable domains. More specifically, the present disclosure relates to a method of producing immunoglobulin single variable domains in which the proportion of carbamylated variants is strongly reduced or absent and to improved immunoglobulin single variable domains obtainable by methods of the present disclosure.
    Type: Application
    Filed: October 28, 2011
    Publication date: October 3, 2013
    Applicant: ABLYNX N.V.
    Inventors: Ann Brige, Bart Walcarius, Yves Meyvis, Mauro Sergi