Patents by Inventor Bartholomeus J. Van Steen

Bartholomeus J. Van Steen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydronopol derivatives as agonists on human ORL1 receptors
    Patent number: 7241770
    Abstract: The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1) wherein the symbols have the meanings as given in the description.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: July 10, 2007
    Assignee: Solvay Pharmaceuticals GmbH
    Inventors: Matthias Mentzel, Dania B. Reiche, Reinhard Brückner, Samuel David, Bartholomeus J. Van Steen, Uwe Schön, Daniel Jasserand, Ulf Preuschoff
  • Benzisoxazole derivatives having d4-antagonistic activity
    Patent number: 6335326
    Abstract: The present invention relates to a group of novel benzisoxazole derivatives which are potent and selective antagonists of the dopamine D4-receptor.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: January 1, 2002
    Assignee: Duphar International Research B.V.
    Inventors: Jacobus A. J. Den Hartog, Gerben M. Visser, Bartholomeus J. Van Steen, Martinus T. M. Tulp, Eric Ronken, Cornelis G. Kruse, Josephus H. M. Lange
  • 2-aminoquinoline derivatives having d4-agonistic activity
    Patent number: 6281216
    Abstract: The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: August 28, 2001
    Assignee: Duphar International Research B.V.
    Inventors: Jacobus A. J. Den Hartog, Gerben M. Visser, Bartholomeus J. Van Steen, Martinus T. M. Tulp, Eric Ronken, Cornelis G. Kruse
  • 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT 1A-antagonistic activity
    Patent number: 5462942
    Abstract: The present invention is concerned with compounds having 5-HT1A antagonistic activity useful in treating CNS disorders and having formula 2 ##STR1## wherein R.sub.1 is halogen, lower alkyl or alkoxy, hydroxy, trifluotomethyl or cyano,m has the value 1 or 2 and n has the value 0 or 1,A represents an alkylene chain containing 2-6 C-atoms which may be substituted with one or more lower alkyl groups or a monocyclic (hetero)aryl group, andB is methylene, ethylene, carbonyl, sulfinyl, sulfonyl or sulfur, and salts thereof.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: October 31, 1995
    Assignee: Duphar International Research B.V.
    Inventors: Jan Hartog, Bartholomeus J. Van Steen, Johannes Mos, Jacques Schipper