Patents by Inventor Bartlomiej Borek
Bartlomiej Borek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240150362Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.Type: ApplicationFiled: August 25, 2023Publication date: May 9, 2024Inventors: Jacek Chrzanowski, Anna Gzik, Joanna Brzezinska, Robert Koralewski, Lukasz Joachimiak, Karolina Rozga, Szymon Kapuscinski, Bartlomiej Borek, Mateusz Urban, Sylwia Ciastek-Iskrzycka, Julita Nowicka, Kamil Lisiecki, Roman Blaszczyk, Adam Golebiowski, Jacek Olczak
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Publication number: 20230219973Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of USP7 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease, disorder, or condition associated with USP7 activity.Type: ApplicationFiled: December 22, 2022Publication date: July 13, 2023Inventors: Jacek CHRZANOWSKI, Julita NOWICKA, Lukasz JOACHIMIAK, Robert KORALEWSKI, Sylwia OLEJNICZAK, Marzena MAZUR, BartlomieJ BOREK, Anna GZIK, Krzysztof MATYSZEWSKI, Sylwia CIASTEK-ISKRZYCKA, Piotr NIEDZIEJKO, Angelika MUCHOWICZ, Zbigniew ZASLONA, Roman BLASZCZYK, Jacek OLCZAK, Adam GOLEBIOWSKI
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Publication number: 20220204530Abstract: The inventive compounds are small molecule therapeutics that are potent inhibitors of arginase 1 and arginase 2 activity. The invention also provides pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.Type: ApplicationFiled: December 22, 2021Publication date: June 30, 2022Inventors: Anna Gzik, Jacek Chrzanowski, Bartlomiej Borek, Roman Blaszczyk, Jacek Olczak, Adam Golebiowski, Marcin Mikolaj Grzybowski, Paulina Pomper
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Publication number: 20220184049Abstract: This application describes methods of treating cystic fibrosis or a CFTR mediated disease comprising administering Compound I or a pharmaceutically acceptable salt thereof. The application also describes pharmaceutical compositions comprising Compound I or a pharmaceutically acceptable salt thereof and optionally comprising one or more additional CFTR modulating agents.Type: ApplicationFiled: December 9, 2021Publication date: June 16, 2022Inventors: Bartlomiej Borek, Weichao George Chen, Rudy Gunawan, Eric Haseltine, Nitin Nair, Porntula Panorchan, Patrick Sosnay
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Publication number: 20220047564Abstract: This application describes methods of treating cystic fibrosis or a CFTR mediated disease comprising administering Compound I or a pharmaceutically acceptable salt thereof. (I) The application also describes pharmaceutical compositions comprising Compound I or a pharmaceutically acceptable salt thereof and optionally comprising one or more additional CFTR modulating agents.Type: ApplicationFiled: November 13, 2019Publication date: February 17, 2022Inventors: David M. ALTSHULER, Corey Don ANDERSON, Bartlomiej BOREK, Weichao George CHEN, Jeremy J. CLEMENS, Thomas CLEVELAND, Timothy Richard COON, Bryan FRIEMAN, Peter GROOTENHUIS, Sara Sabina HADIDA RUAH, Brian J. HARE, Reshma KEWALRAMANI, Jason McCARTNEY, Mark Thomas MILLER, Prasuna PARASELLI, Fabrice PIERRE, Sarah M. ROBERTSON, Patrick R. SOSNAY, Sara E. SWIFT, Fredrick VAN GOOR, Tim YOUNG, Jinglan ZHOU
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Publication number: 20210260019Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.Type: ApplicationFiled: February 5, 2021Publication date: August 26, 2021Inventors: Roman Blaszczyk, Joanna Brzezinska, Anna Gzik, Adam Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Krzysztof Matyszewski, Jacek Olczak
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Patent number: 10912755Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.Type: GrantFiled: August 14, 2019Date of Patent: February 9, 2021Assignee: OncoArendi Therapeutics S.A.Inventors: Roman Blaszczyk, Joanna Brzezinska, Anna Gzik, Adam A. Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Krzysztof Matyszewski, Jacek Olczak
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Patent number: 10851099Abstract: The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.Type: GrantFiled: March 29, 2019Date of Patent: December 1, 2020Assignee: OncoArendi Therapeutics S.A.Inventors: Roman Blaszczyk, Anna Gzik, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Julita Nowicka, Jacek Chrzanowski, Joanna Brzezinska, Adam Golebiowski, Jacek Olczak, Marcin Mikolaj Grzybowski, Jolanta Peczkowicz-Szyszka
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Patent number: 10538508Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.Type: GrantFiled: February 15, 2019Date of Patent: January 21, 2020Assignee: OncoArendi Therapeutics S.A.Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal L. Kowalski
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Publication number: 20190365701Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.Type: ApplicationFiled: August 14, 2019Publication date: December 5, 2019Inventors: Roman Blaszczyk, Joanna Brzezinska, Anna Gzik, Adam A. Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak
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Publication number: 20190345137Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.Type: ApplicationFiled: February 15, 2019Publication date: November 14, 2019Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal L. Kowalski
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Publication number: 20190300525Abstract: The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.Type: ApplicationFiled: March 29, 2019Publication date: October 3, 2019Inventors: Roman Blaszczyk, Anna Gzik, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Julita Nowicka, Jacek Chrzanowski, Joanna Brzezinska, Adam Golebiowski, Jacek Olczak, Marcin Mikolaj Grzybowski, Jolanta Peczkowicz-Szyszka
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Patent number: 10391077Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.Type: GrantFiled: May 2, 2017Date of Patent: August 27, 2019Assignee: OncoArendi Therapeutics S.A.Inventors: Roman Blaszczyk, Joanna Brzezińska, Anna Gzik, Adam Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Krzysztof Matyszewski, Jacek Olczak
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Patent number: 10208020Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.Type: GrantFiled: February 28, 2018Date of Patent: February 19, 2019Assignee: OncoArendi Therapeutics S.A.Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elżbieta Maziarz, Michal Łukasz Kowalski
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Publication number: 20180258071Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.Type: ApplicationFiled: February 28, 2018Publication date: September 13, 2018Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal Lukasz Kowalski
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Patent number: 9944624Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.Type: GrantFiled: September 2, 2016Date of Patent: April 17, 2018Assignee: OncoArendi Therapeutics S.A.Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michał C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elżbieta Maziarz, Michał Łukasz Kowalski
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Publication number: 20170319536Abstract: Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.Type: ApplicationFiled: May 2, 2017Publication date: November 9, 2017Inventors: Roman Blaszczyk, Joanna Brzezinska, Anna Gzik, Adam Golebiowski, Julita Nowicka, Bartlomiej Borek, Marek Dziegielewski, Karol Jedrzejczak, Krzysztof Matyszewski, Jacek Olczak
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Publication number: 20170066743Abstract: Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.Type: ApplicationFiled: September 2, 2016Publication date: March 9, 2017Inventors: Marzena Mazur, Robert Koralewski, Bartlomiej Borek, Sylwia Olejniczak, Wojciech J. Czestkowski, Michal C. Piotrowicz, Jacek P. Olczak, Adam A. Golebiowski, Agnieszka Bartoszewicz, Elzbieta Maziarz, Michal Lukasz Kowalski
