Abstract: The present invention relates to a mixed-charge nanoparticle for inducing selective death of cancer cells and a use thereof. The mixed-charge nanoparticle of the present invention is localized and crystallized specifically in cancer cell lysosomes through a pH-dependent aggregation behavior due to the balance between positively charged ligands and negatively charged ligands on the surface thereof and can induce lysosomal membrane permeabilization (LMP) and lysosomal cell death mediated thereby, like cationic amphiphilic drugs (CADs) Exhibiting a cancer cell-specific death effect, the nanoparticles of the present invention can surmount the limited medical use of conventional cationic nanoparticles due to the non-specific cytotoxicity thereof. Particularly, the nanoparticles of the present invention do not exhibit toxicity to the human body and normal cells, thus finding useful applications in medical and medicinal uses such as for prevention and treatment of solid cancer, blood cancer, and tumors.

Abstract: By keeping track of lists of specific bonds that are to be preserved, a computer program is able to design synthetic routes to create a target compound that avoid that previously published or patented approaches. This may allow the exploration of lower cost or more efficient methods of creating known compounds, or may allow the synthesis of new compunds without the use of patented compunds. Examples of computer-designed syntheses relevant to medicinal chemistry are provided in which the machine avoids “strategic” disconnections common to industrial patents and/or is forced to use different starting materials.

Abstract: A method for analyzing a collection of organic chemical reactions and compounds reported in the literature in the form of a complex network in either a normal, one-mode graph or a bipartite graph is disclosed. Also disclosed are methods, algorithms, computer-readable storage mediums and other applications derived from the analysis of this graph/network theory.

Abstract: Anti-static polymer compositions for use with electronic devices susceptible to static electricity are provided. The composition includes a polymer and a free radical scavenger additive.

Abstract: Self-erasing inks in which both the printing and self-erasure of color images can be controlled by the dynamic/non-equilibrium aggregation of photoresponsive surface-coated nanoparticles contained in a carrier film are provided. The aggregation is a reversible aggregation that is triggered by a photo-induced transformation in ligands within the surface coating on the nanoparticles. Methods for forming images using the inks are also provided.

Abstract: Self-erasing inks in which both the printing and self-erasure of color images can be controlled by the dynamic/non-equilibrium aggregation of photoresponsive surface-coated nanoparticles contained in a carrier film are provided. The aggregation is a reversible aggregation that is triggered by a photo-induced transformation in ligands within the surface coating on the nanoparticles. Methods for forming images using the inks are also provided.

Abstract: A method for analyzing a collection of organic chemical reactions and compounds reported in the literature in the form of a complex network in either a normal, one-mode graph or a bipartite graph is disclosed. Also disclosed are methods, algorithms, computer-readable storage mediums and other applications derived from the analysis of this graph/network theory.

Abstract: Solutions containing oppositely-charged nanoparticles (NPs) deposit “patchy” coatings of alternating charge distribution on various types of materials, including polymers, elastomers, and semiconductors. Surface adsorption of the NPs is driven by cooperative electrostatic interactions and does not require chemical ligation or layer-by-layer schemes. The composition and the quality of the coatings can be regulated by the types, charges, and the relative concentrations of the NPs used and by the pH. Dense coatings can be formed on flat, curvilinear, or micropatterned surfaces. The coatings are stable against common chemicals for prolonged periods of time, and can be used in applications ranging from bacterial protection to plasmonics.