Abstract: The present invention provides a deformable body (2), wherein the deformable body comprises a force application surface (12) opposite a bone contact surface (52) to be pressed against periosteum of a bone surface (52) of a bone such that the bone contact surface adapts its shape to the shape of the bone surface, wherein the deformable body comprises one or more through-going openings (3) and/or one or more fixation locations (34) arranged to receive a fixation element such as screw (20), and wherein the deformable body comprises an anaesthetic that is released from or through the bone contact surface. The anaesthetic can be bupivicaine, liposome bupivacaine, lidocaine or levobupivacaine. The anaestetic can be arranged in one or more compartments (6, 7) which have different release rates. The screw can comprise a detent or rim to mate with the deformable body. A sleeve (80) can be arranged in the opening (3) to receive the screw.

Abstract: The present invention relates to an adhesive drug carrier comprising an injectable hydrogel comprising at least one medication, wherein the hydrogel comprises a (i) a protein-based polymer functionalized with a functionalization agent that is able to form guest-host interactions with oxidized P-cyclodextrin, cross-linked with (ii) an oxidized P-cyclodextrin (o?-CD) as matrix and the at least one medication (iii), and wherein the hydrogel further comprises (iv) a protein-based polymer bearing quinone and/or catechol groups. The invention further relates to a method for its preparation and a method for treatment.

Abstract: The present invention provides a deformable body (2), wherein the deformable body comprises a force application surface (12) opposite a bone contact surface (52) to be pressed against periosteum of a bone surface (52) of a bone such that the bone contact surface adapts its shape to the shape of the bone surface, wherein the deformable body comprises one or more through-going openings (3) and/or one or more fixation locations (34) arranged to receive a fixation element such as as screw (20), and wherein the deformable body comprises an anaesthetic that is released from or through the bone contact surface. The anaesthetic can be bupivicaine, liposome bupivacaine, lidocaine or levobupivacaine. The anaestethic can be arranged in one or more compartments (6, 7) which have ifferent release rates. The screw can comprise a detent or rim to mate with the deformable body. A sleeve (80) can be arranged in the opening (3) to receive the screw.

Abstract: The present invention provides a deformable body (2), wherein the deformable body comprises a force application surface (12) opposite a bone contact surface (52) to be pressed against periosteum of a bone surface (52) of a bone such that the bone contact surface adapts its shape to the shape of the bone surface, wherein the deformable body comprises one or more through-going openings (3) and/or one or more fixation locations (34) arranged to receive a fixation element such as as screw (20), and wherein the deformable body comprises an anaesthetic that is released from or through the bone contact surface. The anaesthetic can be bupivicaine, liposome bupivacaine, lidocaine or levobupivacaine. The anaesthetic can be arranged in one or more compartments (6, 7) which have different release rates. The screw can comprise a detent or rim to mate with the deformable body. A sleeve (80) can be arranged in the opening (3) to receive the screw.

Abstract: The invention provides a sleeve element (1) to be placed on a neck (53) of a prosthetic hip (51) or shoulder implant, wherein the sleeve element is made of a biodegradable elastically deformable material comprising a medical active agent to be released from the sleeve element. The sleeve element may comprise a longitudinal channel (2) and a longitudinal slit (3) extending over the length of the longitudinal channel and between the longitudinal channel and an outer surface of the sleeve element, wherein the sleeve element is elastically deformable between a closed state and an opened state, wherein a width of the longitudinal slit in the opened state is larger than the width of the longitudinal slit in the closed state. The invention also provides a prosthetic kit, comprising a prosthetic hip or shoulder implant having a neck, and the above sleeve element.

Abstract: A hydrogel for in-vivo release of medication includes at least one medication, where the hydrogel includes (i) a protein-based biopolymer functionalized with a functionalisation agent that is able to form guest-host interactions with oxidized ?-cyclodextrin, preferably a primary aminoalkylphenol, more preferably gelatin functionalized with tyramine (GTA) and (ii) oxidized ?-cyclodextrin (o?-CD), where the hydrogel is cross-linked via exposure to visible light in presence of a biocompatible photoinitiator, resulting in a degree of swelling in the range of 2-20 calculated as (swollen weight?dry weight)/dry weight. It further relates to a method for its preparation, as well as to a medication for treatment of musculoskeletal disorders, preferably for treatment of infection, inflammation, malignant processes, growth disorders, degenerative disorders or treatment of pain arising from (surgical treatment of) these disorders.

Abstract: The invention provides a hydrogel for in-vivo release of medication comprising at least one medication, wherein the surface of the hydrogel comprises a coating such that the surface has one or more sub-surfaces with permeability that is at least 2× higher than the average permeability of the entire surface, wherein the hydrogel has an elastic modulus of between 50 and 1000 kPa.

Abstract: The present invention provides a deformable body (2), wherein the deformable body comprises a force application surface (12) opposite a bone contact surface (52) to be pressed against periosteum of a bone surface (52) of a bone such that the bone contact surface adapts its shape to the shape of the bone surface, wherein the deformable body comprises one or more through-going openings (3) and/or one or more fixation locations (34) arranged to receive a fixation element such as as screw (20), and wherein the deformable body comprises an anaesthetic that is released from or through the bone contact surface. The anaesthetic can be bupivicaine, liposome bupivacaine, lidocaine or levobupivacaine. The anaesthetic can be arranged in one or more compartments (6, 7) which have different release rates. The screw can comprise a detent or rim to mate with the deformable body. A sleeve (80) can be arranged in the opening (3) to receive the screw.

Abstract: A steam ironing device includes a water supply device, a steam generator for generating steam, a heating element for heating the steam generator, at least one atomizating device, a valve provided in a flow path between the steam generator and the atomizing device, and an electric pump for delivering water from said water supply device to said steam generator. To obtain wet steam at the atomizing device, the ironing device includes a control device for controlling the power of the heating element of the steam generator, for controlling the flow rate of the pump, and for controlling the opening and closing of the valve, the valve being open if the ratio between the flow rate (g/min) of the pump and the power (W) of the heating element is in a range of 1:20 to 1:38.

Abstract: The invention provides an ion exchange cartridge (13), in particular for a domestic appliance that comprises between a water inlet (1A) and a water outlet (2A) a weak acid ion exchanger in the H+ form (5), followed by a strong acid ion exchanger in the Na+ form (7). This cartridge may be compact because it removes hard scale forming ions only. The cartridge may further comprise a first (16) and a second probe (17) to measure hard scale causing ions by a differential measurement of the conductivity of incoming water and water that has passed one or both ion exchangers. Herewith the appliance can be switched off when the cartridge is not functioning anymore, thus forcing a user to replace the cartridge, or to regenerate the ion exchangers before hard scale blocking of the appliance.