Patents by Inventor Bas van Steensel

Bas van Steensel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of in vivo dna binding loci of chromatin proteins using a tethered nucleotide modification enzyme
    Publication number: 20030212455
    Abstract: A novel technique is provided, designated DamID, for the identification of DNA loci that interact in vivo with specific nuclear proteins in eukaryotes. By tethering a DNA modification enzyme, in particular, E. coli DNA adenine methyl transferase (Dam), to a chromatin protein. The DNA modification enzyme (Dam) can be targeted in vivo to the native binding loci of the protein, resulting in local DNA modification. Sites of DNA modification can subsequently be mapped using modification-specific restriction enzymes, antibodies, or DNA array methods. DNA Modification Identification (DamID) has potential for genome-wide mapping of in vivo target binding sites of chromatin proteins in various eukaryotes.
    Type: Application
    Filed: March 11, 2003
    Publication date: November 13, 2003
    Inventors: Bas Van Steensel, Steven Henikoff
  • Nucleic acid encoding an altered telomere repeat binding factor
    Patent number: 6022709
    Abstract: The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRF) that hinders the binding of a TRF to its specific telomere repeat sequence. Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: February 8, 2000
    Assignee: The Rockefeller University
    Inventors: Titia de Lange, Bas van Steensel, Alessandro Bianchi
  • Nucleic acid encoding an altered telomere repeat binding factor 2
    Patent number: 6020166
    Abstract: The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: February 1, 2000
    Assignee: The Rockfeller University
    Inventors: Titia De Lange, Bas Van Steensel, Alessandro Bianchi
  • Altered telomere repeat binding factor 2
    Patent number: 5917019
    Abstract: The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
    Type: Grant
    Filed: February 4, 1998
    Date of Patent: June 29, 1999
    Assignee: The Rockefeller University
    Inventors: Titia de Lange, Bas Van Steensel, Alessandro Bianchi
  • Altered telomere repeat binding factor
    Patent number: 5859183
    Abstract: The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRF) that hinders the binding of a TRF to its specific telomere repeat sequence. Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: January 12, 1999
    Assignee: The Rockefeller University
    Inventors: Titia de Lange, Bas van Steensel, Alessandro Bianchi