Abstract: The present disclosure features devices and kits for performing a kyphoplasty and methods of use thereof.

Abstract: The present disclosure features imaging media including a contrast agent encapsulated within a biodegradable nanoparticle matrix. The particles are sized such that they avoid excretion via urinary excretion (e.g., at least 5 nm in diameter) during an imaging procedure or an image-guided procedure. Instead, the particles are predominantly removed from circulation by the reticuloendothelial system of the liver. This results in a buildup of contrast agent in the liver, allowing for a highly specific imaging modality for liver imaging. Further, the bulk of the imaging media is excreted into the bowel, reducing in-vivo toxicity of the imaging media. Finally, because of their size, the nanoparticles of the imaging media have a higher circulation half-life.

Abstract: The present disclosure features devices, systems, and kits for vascular occlusion and methods of use thereof.

Abstract: The present disclosure provides devices and systems for performing thrombectomies and methods of use thereof.

Abstract: The present disclosure features devices, systems, and kits for vascular occlusion and methods of use thereof.

Abstract: The present disclosure features devices and kits for performing a kyphoplasty and methods of use thereof.

Abstract: The present disclosure provides devices and systems for performing thrombectomies and methods of use thereof.

Abstract: The present disclosure features radiopharmaceutical compositions including a radionuclide and an imaging agent encapsulated within, embedded in, or conjugated to a nanoparticle (e.g., via a complexing moiety, such as a chelator), and methods of their use. The radiopharmaceuticals may be formulated for direct administration to the diseased tissue, with minimal or no washout of the radiopharmaceutical to non-target sites within a subject. The radiopharmaceuticals of the present disclosure allow for efficient treatment of diseased tissue proximal to the site of administration with minimal to no damage to the surrounding tissue.

Abstract: The present disclosure features imaging media including a contrast agent encapsulated within a biodegradable nanoparticle matrix. The particles are sized such that they avoid excretion via urinary excretion (e.g., at least 5 nm in diameter) during an imaging procedure or an image-guided procedure. Instead, the particles are predominantly removed from circulation by the reticuloendothelial system of the liver. This results in a buildup of contrast agent in the liver, allowing for a highly specific imaging modality for liver imaging. Further, the bulk of the imaging media is excreted into the bowel, reducing in-vivo toxicity of the imaging media. Finally, because of their size, the nanoparticles of the imaging media have a higher circulation half-life.

Abstract: The present disclosure provides devices and systems for performing thrombectomies and methods of use thereof.

Abstract: The present disclosure features devices, systems, and kits for vascular occlusion and methods of use thereof.

Abstract: The present disclosure features radiopharmaceutical compositions including a radionuclide and an imaging agent encapsulated within, embedded in, or conjugated to a nanoparticle (e.g., via a complexing moiety, such as a chelator), and methods of their use. The radiopharmaceuticals may be formulated for direct administration to the diseased tissue, with minimal or no washout of the radiopharmaceutical to non-target sites within a subject. The radiopharmaceuticals of the present disclosure allow for efficient treatment of diseased tissue proximal to the site of administration with minimal to no damage to the surrounding tissue.

Abstract: The present invention relates to compositions and methods for imaging and treating various diseases and disorders, including cancers. The composition of the invention can include a plurality of biodegradable micro-beads, each embedding a plurality of nano-beads, further including a polymer, a radionuclide, a radionuclide chelator, a radioligand, a chemotherapeutic agent, and a cell-penetrating peptide. Upon injection into a blood vessel supplying a cancer tumor, the micro-beads lodge into the tumor and degrade, releasing the nano-beads with a therapeutic or diagnostic agent. The compositions and methods of the invention provide a more homogeneous and deeper distribution of radiation or chemotherapeutic agents throughout the target tumor. The micro-beads provide a local, sustained, and controlled delivery nano-beads including therapeutic or diagnostic agents.

Abstract: The present invention relates to compositions and methods for imaging and treating various diseases and disorders, including cancers. The composition of the invention can include a plurality of biodegradable micro-beads, each embedding a plurality of nano-beads, further including a polymer, a radionuclide, a radionuclide chelator, a radioligand, a chemotherapeutic agent, and a cell-penetrating peptide. Upon injection into a blood vessel supplying a cancer tumor, the micro-beads lodge into the tumor and degrade, releasing the nano-beads with a therapeutic or diagnostic agent. The compositions and methods of the invention provide a more homogeneous and deeper distribution of radiation or chemotherapeutic agents throughout the target tumor. The micro-beads provide a local, sustained, and controlled delivery nano-beads including therapeutic or diagnostic agents.

Abstract: The present invention relates to compositions and methods for imaging and treating various diseases and disorders, including cancers. The composition of the invention can include a plurality of biodegradable micro-beads, each embedding a plurality of nano-beads, further including a polymer, a radionuclide, a radionuclide chelator, a radioligand, a chemotherapeutic agent, and a cell-penetrating peptide. Upon injection into a blood vessel supplying a cancer tumor, the micro-beads lodge into the tumor and degrade, releasing the nano-beads with a therapeutic or diagnostic agent. The compositions and methods of the invention provide a more homogeneous and deeper distribution of radiation or chemotherapeutic agents throughout the target tumor. The micro-beads provide a local, sustained, and controlled delivery nano-beads including therapeutic or diagnostic agents.

Abstract: A flexible heart valve prosthetic device includes a flexible frame having multiple struts disposed radially around a central axis, each strut joined at a proximal end and a distal end, a mesh band attached to each strut between their proximal ends and their distal ends, a deployable anchoring assembly having a deployable hook positioned on each strut within the mesh band, a retrieval hook positioned at the distal and/or proximal ends of the struts, and leaflets radially disposed within the mesh band. A method of releasably anchoring a flexible heart valve prosthetic within the annulus of the heart of a subject is also disclosed.

Abstract: An expandable vascular sheath utilizes a set of expandable members such as shape memory alloy wires for expanding its distal end. The wires are slidable along a portion of the sheath's elongate shaft. In certain embodiments, the distal end of the shaft is manufactured with a more pliable and elastic polymer relative to more proximal portions of the elongate shaft, so that as the wires advance into distal portions of the shaft, they expand, causing the distal end opening of the shaft to expand. A method for retrieving a foreign object from a vasculature utilizes a retrieval tool that can be advanced through the expandable vascular sheath.

Abstract: An expandable vascular sheath utilizes a set of expandable members such as shape memory alloy wires for expanding its distal end. The wires are slidable along a portion of the sheath's elongate shaft. In certain embodiments, the distal end of the shaft is manufactured with a more pliable and elastic polymer relative to more proximal portions of the elongate shaft, so that as the wires advance into distal portions of the shaft, they expand, causing the distal end opening of the shaft to expand. A method for retrieving a foreign object from a vasculature utilizes a retrieval tool that can be advanced through the expandable vascular sheath.