Abstract: A system and method for repairing a damaged peripheral nerve is provided. A coupler includes a stabilizing assembly applied to a distal end of a damaged area of the nerve and applied to a proximal end of the damaged area, the coupler adapted so that the proximal end and the distal end are maintained in a stabile abutting relationship in which nerve repair can occur. A chamber is placed in proximity to the damaged area, having a therapeutic agent. Illustratively, the distal end and the proximal end are severed from each other. The coupler can define one of (a) coupler halves that surround the proximal end and the distal end and allow fixing members to be applied to the proximal end and the distal end and (b) cuffs that engage, and are fixed to, each of the proximal end and the distal end and are engaged by overlying coupler halves.