Patents by Inventor Bassam M. Fraij

Bassam M. Fraij has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Active human cellular transglutaminase
    Patent number: 6190896
    Abstract: Known cellular transglutaminase is produced as an inactive precursor which is converted to the active species. As described herein, the active species have been identified, cloned, mass produced and purified from bacterial cells. The active transglutaminase herein are useful as a biological glue for, inter alia, adhesive strength in general surgery, clinical orthopedics, skin wound repair, tissue repair, implants, tissue or organ transplantation, stomach and duodenal ulcers, food industry, technical applications, and in applications for cellular apoptosis.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: February 20, 2001
    Inventor: Bassam M. Fraij
  • Transglutaminase gene
    Patent number: 5726051
    Abstract: The present invention relates to a 1.9 kb cDNA and new tissue transglutaminase protein encoded thereby. The cDNA was obtained from reverse transcription of mRNA isolated from retinoic-acid treated HEL cells. The invention also relates to vectors and expression systems to produce the new tissue transglutaminase as well as the recombinantly-produced enzyme protein.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: March 10, 1998
    Assignee: Oklahoma Medical Research Foundation
    Inventors: Bassam M. Fraij, Paul J. Birckbichler, Manford K. Patterson, Jr., Robert A. Gonzales