Abstract: Disclosed herein is a bioreactor for creating and/or conditioning biological tissues, in particular cardiovascular patches. This bioreactor supports additionally cellular differentiation under controlled conditions. The bioreactor comprises a housing having a first section (20) for holding a nutrition solution and/or a cell suspension (24), means (28) for holding a scaffold (34), said means being disposed or disposable inside said bioreactor housing such that said scaffold (34) held therein is exposed to said nutrition solution and/or cell suspension (24) when contained in said first section (20), mechanical stimulation means (54, 68, 86) for applying mechanical stress and/or strain to said scaffold (34) and/or tissue formed thereon when held by said scaffold holding means (28) in said bioreactor housing, and electrical stimulation means (38, 92) for applying an electrical stimulation to said scaffold (34) and/or tissue formed thereon when held by said scaffold holding means (28) in said bioreactor housing.

Abstract: Disclosed herein is a method of examining tissue growth and/or conditioning and/or adhesion properties of cells on a synthetic and/or natural scaffold (30) as well as a perfusion bioreactor (10) for use in this method.

Abstract: The present invention relates to an apparatus (1) for automated exploitation of cells from a sample, comprising a plurality of dispensing containers (2) for the separated storage of fluid media, each dispensing container comprising an outlet (21) wherein a media delivery arrangement (3) is associated to each of the dispensing containers (2) and a first valve (22) is connected to each of the outlets (21), a plurality of collecting containers (4) for the collection of fluid media, each collecting container (4) comprising an inlet (41) wherein a second valve (42) is connected to the inlet (41) of each collecting container, and a mounting device (5) for mounting the sample, the mounting device comprising an inlet (51) being connected to the first valve (22), and an outlet (52), wherein the outlet (52) of the mounting device is connected to the second valve (42). Further, the present invention enables a method for automated cell exploitation from a sample by the use of the apparatus (1).