Patents by Inventor Bastien Mairesse

Bastien Mairesse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250243443
    Abstract: A bioreactor includes a housing with a number of removable parts for modular construction and easy assembly or disassembly. The removable parts include a fixed bed and a support for the fixed bed. More than one support may be provided. The multiple supports may interlock with each other or a lid of the bioreactor. The support interlocks with the housing to prevent relative rotation. The multiple supports include a support frame for supporting the fixed bed an allowing fluid to flow through the support frame. The fixed bed forms a peripheral chamber between the support and the housing to hold the fixed bed. One or more probes and tubes may be inserted into the bioreactor to test parameters of or to add to or remove liquid from inside.
    Type: Application
    Filed: April 7, 2023
    Publication date: July 31, 2025
    Inventors: Bart Heeren, Antoine Hubert, Bastien Mairesse, Clement Dumont, Guillaume Belhaj, Jean-Christophe Drugmand
  • Patent number: 12351793
    Abstract: The current disclosure concerns a system for producing biomolecules comprising a docking station (30), said docking station encompasses: —a bioreactor (1); —a concentrator (2) fluidly linked to the bioreactor; —an intermediate vessel (4), positioned between said bioreactor (1) and concentrator (2), wherein said intermediate vessel (4) and concentrator (2) are connected by a retentate conduit (303), allowing recirculating of liquid from an output of the concentrator to an input of said intermediate vessel and—a controller, integrated in said docking station (30), which is able to control the biomolecule process.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: July 8, 2025
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: Bastien Mairesse, Laetitia De Viron, Alex Chatel
  • Publication number: 20250145935
    Abstract: The current disclosure concerns a system for producing biomolecules comprising a bioreactor including a chamber (1) suitable for receiving a liquid comprising cells and viral particles; and a concentrator (2), wherein said concentrator is equipped with a retenate conduit (300, 303) suitable for collecting said retentate and facilitating recirculating of the retentate to an input of said bioreactor or to an input of an intermediate vessel (4) positioned between said concentrator and said bioreactor. In a second and third aspect the disclosure concerns a method for producing biomolecules and the use of the disclosed system for the production of biomolecules.
    Type: Application
    Filed: November 15, 2024
    Publication date: May 8, 2025
    Inventors: José Castillo, Bastien Mairesse, Laetitia De Viron, Jean-Christophe Drugmand
  • Publication number: 20240399364
    Abstract: The invention provides a method and a system for the production of viruses or virus derived products. The system comprises a containment enclosure provided with a single entry means and a single exit means which are movable between a closed position and an open position. The containment enclosure comprises at least one production unit comprising at least one bioreactor for culturing the virus, said bioreactor is provided with at least one inlet and at least one outlet; at least one purification unit fluidly connected to the production unit and comprising at least one purification means having at least one inlet and at least one outlet. The system further comprises at least one inactivation and/or at least one gas decontamination unit. The containment enclosure comprises at least one process control device connected to the exit means. The movement of the exit means from the closed position to the open position is controllable by said process control device.
    Type: Application
    Filed: June 25, 2024
    Publication date: December 5, 2024
    Inventors: José Castillo, Bastien Mairesse
  • Patent number: 12152231
    Abstract: The current disclosure concerns a system for producing biomolecules comprising a bioreactor including a chamber (1) suitable for receiving a liquid comprising cells and viral particles; and a concentrator (2), wherein said concentrator is equipped with a retentate conduit (300, 303) suitable for collecting said retentate and facilitating recirculating of the retentate to an input of said bioreactor or to an input of an intermediate vessel (4) positioned between said concentrator and said bioreactor. In a second and third aspect the disclosure concerns a method for producing biomolecules and the use of the disclosed system for the production of biomolecules.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: November 26, 2024
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Laetitia De Viron, Jean-Christophe Drugmand
  • Publication number: 20240279598
    Abstract: Systems and methods for harvesting cells include a bioreactor with a structure for cell entrapment/adherence and growth, such as a fixed bed structure. A cell harvest mechanism is adapted to agitate the bioreactor, such as by vibrating or shaking the fixed bed, and to move a liquid level relative to the structure, such as by repeatedly flushing and filling the bioreactor. A cell detaching solution is provided to the bioreactor, such as an enzymatic cocktail for the detachment of cells without producing clumps or aggregates. The bioreactor may comprise a preculture vessel upstream of another bioreactor.
    Type: Application
    Filed: June 3, 2022
    Publication date: August 22, 2024
    Inventors: Jean-Christophe Drugmand, Bastien Mairesse, José Castillo, Christophe Dumont, Sebastien Rodriguez, Antoine Hubert, Tania Pereira Chilima
  • Publication number: 20240254419
    Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.
    Type: Application
    Filed: December 29, 2023
    Publication date: August 1, 2024
    Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
  • Patent number: 12036549
    Abstract: The invention provides a method and a system for the production of viruses or virus derived products. The system comprises a containment enclosure provided with a single entry means and a single exit means which are movable between a closed position and an open position. The containment enclosure comprises at least one production unit comprising at least one bioreactor for culturing the virus, said bioreactor is provided with at least one inlet and at least one outlet; at least one purification unit fluidly connected to the production unit and comprising at least one purification means having at least one inlet and at least one outlet. The system further comprises at least one inactivation and/or at least one gas decontamination unit. The containment enclosure comprises at least one process control device connected to the exit means. The movement of the exit means from the closed position to the open position is controllable by said process control device.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: July 16, 2024
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse
  • Publication number: 20240200010
    Abstract: A sampler for use with a bioreactor for growing a cell culture is disclosed. In one embodiment, the bioreactor includes a structured fixed bed including a removable sample portion for recovering a sample of cells from the cell culture. Related apparatuses and methods are also disclosed.
    Type: Application
    Filed: March 1, 2024
    Publication date: June 20, 2024
    Inventors: José Castillo, Bastien Mairesse, Alex Chatel, Sebastien Jean-Pierre Michel Rodriguez, Alexandre Vanhaver
  • Patent number: 11946032
    Abstract: A sampler for use with a bioreactor for growing a cell culture is disclosed. In one embodiment, the bioreactor includes a structured fixed bed including a removable sample portion for recovering a sample of cells from the cell culture. Related apparatuses and methods are also disclosed.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: April 2, 2024
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Alex Chatel, Sebastien Jean-Pierre Michel Rodriguez, Alexandre VAnhaver
  • Publication number: 20240002769
    Abstract: An apparatus for culturing cells includes a bioreactor including a monolithic structured cell culture bed, which may be fabricated using additive manufacturing techniques, such as for example 3D printing. The bioreactor and monolithic structured cell culture bed may be formed as a unitary structure. The monolithic structured cell culture bed may include regions of varying porosity and/or surface treatments to achieve desired objectives. Related methods are also provided.
    Type: Application
    Filed: December 2, 2021
    Publication date: January 4, 2024
    Inventors: Christophe Dumont, Tania Pereira Chilima, Antoine Hubert, Jean-Christophe Drugmand, José Castillo, Sebastien Rodriguez, Bastien Mairesse
  • Patent number: 11827873
    Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: November 28, 2023
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem
  • Publication number: 20230272324
    Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.
    Type: Application
    Filed: May 4, 2023
    Publication date: August 31, 2023
    Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
  • Publication number: 20230227767
    Abstract: A system includes a bioprocessing vessel formed of a material insulative to a liquid medium when present therein. At least one sensor is for sensing a parameter of the bioprocessing vessel and generating a signal indicative of the parameter. At least ne conductor is adapted to provide electrical communication between the liquid medium in the bioprocessing vessel and an external structure to achieve equipotential for reducing noise in the signal produced by the at least one sensor. Related apparatus and methods are also disclosed.
    Type: Application
    Filed: May 11, 2021
    Publication date: July 20, 2023
    Inventors: Bastien Mairesse, Jean-Christophe Drugmand
  • Patent number: 11680237
    Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: June 20, 2023
    Assignee: UNIVERCELLS TECHNOLOGIES S.A.
    Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
  • Publication number: 20230017014
    Abstract: An apparatus for culturing cells with enhanced gas transfer and thermal regulation is provided. The apparatus includes a bioreactor with a cell culture bed, such as a fixed structured bed. A pump, such as an agitator, serves to pump liquid through the cell culture bed, and a container is provided for the agitator. A first conduit may be associated with the container, such as by being connected to it or adjacent an opening into it. The bioreactor may also include flow extenders to enhance the gas transfer to a liquid used as media to culture the cells, as well as optional thermoregulators. Related methods are also disclosed.
    Type: Application
    Filed: December 2, 2020
    Publication date: January 19, 2023
    Inventors: Jean-Christophe Drugmand, Bart Karel Johan Heeran, Christophe Dumont, Xavier Gabet, José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez, Florent Van Hijfte
  • Publication number: 20220396754
    Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.
    Type: Application
    Filed: August 15, 2022
    Publication date: December 15, 2022
    Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
  • Publication number: 20220235308
    Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.
    Type: Application
    Filed: April 15, 2022
    Publication date: July 28, 2022
    Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem
  • Publication number: 20220081664
    Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 17, 2022
    Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem
  • Patent number: D1069155
    Type: Grant
    Filed: September 15, 2023
    Date of Patent: April 1, 2025
    Assignee: Quantoom Biosciences, société anonyme
    Inventors: Anne De Lamotte, Bastien Mairesse, José Castillo