Patents by Inventor Bastien Mairesse
Bastien Mairesse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250243443Abstract: A bioreactor includes a housing with a number of removable parts for modular construction and easy assembly or disassembly. The removable parts include a fixed bed and a support for the fixed bed. More than one support may be provided. The multiple supports may interlock with each other or a lid of the bioreactor. The support interlocks with the housing to prevent relative rotation. The multiple supports include a support frame for supporting the fixed bed an allowing fluid to flow through the support frame. The fixed bed forms a peripheral chamber between the support and the housing to hold the fixed bed. One or more probes and tubes may be inserted into the bioreactor to test parameters of or to add to or remove liquid from inside.Type: ApplicationFiled: April 7, 2023Publication date: July 31, 2025Inventors: Bart Heeren, Antoine Hubert, Bastien Mairesse, Clement Dumont, Guillaume Belhaj, Jean-Christophe Drugmand
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Patent number: 12351793Abstract: The current disclosure concerns a system for producing biomolecules comprising a docking station (30), said docking station encompasses: —a bioreactor (1); —a concentrator (2) fluidly linked to the bioreactor; —an intermediate vessel (4), positioned between said bioreactor (1) and concentrator (2), wherein said intermediate vessel (4) and concentrator (2) are connected by a retentate conduit (303), allowing recirculating of liquid from an output of the concentrator to an input of said intermediate vessel and—a controller, integrated in said docking station (30), which is able to control the biomolecule process.Type: GrantFiled: June 27, 2019Date of Patent: July 8, 2025Assignee: UNIVERCELLS TECHNOLOGIES S.A.Inventors: Bastien Mairesse, Laetitia De Viron, Alex Chatel
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Publication number: 20250145935Abstract: The current disclosure concerns a system for producing biomolecules comprising a bioreactor including a chamber (1) suitable for receiving a liquid comprising cells and viral particles; and a concentrator (2), wherein said concentrator is equipped with a retenate conduit (300, 303) suitable for collecting said retentate and facilitating recirculating of the retentate to an input of said bioreactor or to an input of an intermediate vessel (4) positioned between said concentrator and said bioreactor. In a second and third aspect the disclosure concerns a method for producing biomolecules and the use of the disclosed system for the production of biomolecules.Type: ApplicationFiled: November 15, 2024Publication date: May 8, 2025Inventors: José Castillo, Bastien Mairesse, Laetitia De Viron, Jean-Christophe Drugmand
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Publication number: 20240399364Abstract: The invention provides a method and a system for the production of viruses or virus derived products. The system comprises a containment enclosure provided with a single entry means and a single exit means which are movable between a closed position and an open position. The containment enclosure comprises at least one production unit comprising at least one bioreactor for culturing the virus, said bioreactor is provided with at least one inlet and at least one outlet; at least one purification unit fluidly connected to the production unit and comprising at least one purification means having at least one inlet and at least one outlet. The system further comprises at least one inactivation and/or at least one gas decontamination unit. The containment enclosure comprises at least one process control device connected to the exit means. The movement of the exit means from the closed position to the open position is controllable by said process control device.Type: ApplicationFiled: June 25, 2024Publication date: December 5, 2024Inventors: José Castillo, Bastien Mairesse
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Patent number: 12152231Abstract: The current disclosure concerns a system for producing biomolecules comprising a bioreactor including a chamber (1) suitable for receiving a liquid comprising cells and viral particles; and a concentrator (2), wherein said concentrator is equipped with a retentate conduit (300, 303) suitable for collecting said retentate and facilitating recirculating of the retentate to an input of said bioreactor or to an input of an intermediate vessel (4) positioned between said concentrator and said bioreactor. In a second and third aspect the disclosure concerns a method for producing biomolecules and the use of the disclosed system for the production of biomolecules.Type: GrantFiled: September 27, 2018Date of Patent: November 26, 2024Assignee: UNIVERCELLS TECHNOLOGIES S.A.Inventors: José Castillo, Bastien Mairesse, Laetitia De Viron, Jean-Christophe Drugmand
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Publication number: 20240279598Abstract: Systems and methods for harvesting cells include a bioreactor with a structure for cell entrapment/adherence and growth, such as a fixed bed structure. A cell harvest mechanism is adapted to agitate the bioreactor, such as by vibrating or shaking the fixed bed, and to move a liquid level relative to the structure, such as by repeatedly flushing and filling the bioreactor. A cell detaching solution is provided to the bioreactor, such as an enzymatic cocktail for the detachment of cells without producing clumps or aggregates. The bioreactor may comprise a preculture vessel upstream of another bioreactor.Type: ApplicationFiled: June 3, 2022Publication date: August 22, 2024Inventors: Jean-Christophe Drugmand, Bastien Mairesse, José Castillo, Christophe Dumont, Sebastien Rodriguez, Antoine Hubert, Tania Pereira Chilima
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Publication number: 20240254419Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.Type: ApplicationFiled: December 29, 2023Publication date: August 1, 2024Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
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Patent number: 12036549Abstract: The invention provides a method and a system for the production of viruses or virus derived products. The system comprises a containment enclosure provided with a single entry means and a single exit means which are movable between a closed position and an open position. The containment enclosure comprises at least one production unit comprising at least one bioreactor for culturing the virus, said bioreactor is provided with at least one inlet and at least one outlet; at least one purification unit fluidly connected to the production unit and comprising at least one purification means having at least one inlet and at least one outlet. The system further comprises at least one inactivation and/or at least one gas decontamination unit. The containment enclosure comprises at least one process control device connected to the exit means. The movement of the exit means from the closed position to the open position is controllable by said process control device.Type: GrantFiled: November 8, 2017Date of Patent: July 16, 2024Assignee: UNIVERCELLS TECHNOLOGIES S.A.Inventors: José Castillo, Bastien Mairesse
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Publication number: 20240200010Abstract: A sampler for use with a bioreactor for growing a cell culture is disclosed. In one embodiment, the bioreactor includes a structured fixed bed including a removable sample portion for recovering a sample of cells from the cell culture. Related apparatuses and methods are also disclosed.Type: ApplicationFiled: March 1, 2024Publication date: June 20, 2024Inventors: José Castillo, Bastien Mairesse, Alex Chatel, Sebastien Jean-Pierre Michel Rodriguez, Alexandre Vanhaver
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Patent number: 11946032Abstract: A sampler for use with a bioreactor for growing a cell culture is disclosed. In one embodiment, the bioreactor includes a structured fixed bed including a removable sample portion for recovering a sample of cells from the cell culture. Related apparatuses and methods are also disclosed.Type: GrantFiled: March 18, 2019Date of Patent: April 2, 2024Assignee: UNIVERCELLS TECHNOLOGIES S.A.Inventors: José Castillo, Bastien Mairesse, Alex Chatel, Sebastien Jean-Pierre Michel Rodriguez, Alexandre VAnhaver
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Publication number: 20240002769Abstract: An apparatus for culturing cells includes a bioreactor including a monolithic structured cell culture bed, which may be fabricated using additive manufacturing techniques, such as for example 3D printing. The bioreactor and monolithic structured cell culture bed may be formed as a unitary structure. The monolithic structured cell culture bed may include regions of varying porosity and/or surface treatments to achieve desired objectives. Related methods are also provided.Type: ApplicationFiled: December 2, 2021Publication date: January 4, 2024Inventors: Christophe Dumont, Tania Pereira Chilima, Antoine Hubert, Jean-Christophe Drugmand, José Castillo, Sebastien Rodriguez, Bastien Mairesse
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Patent number: 11827873Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.Type: GrantFiled: July 20, 2020Date of Patent: November 28, 2023Assignee: UNIVERCELLS TECHNOLOGIES S.A.Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem
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Publication number: 20230272324Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.Type: ApplicationFiled: May 4, 2023Publication date: August 31, 2023Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
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Publication number: 20230227767Abstract: A system includes a bioprocessing vessel formed of a material insulative to a liquid medium when present therein. At least one sensor is for sensing a parameter of the bioprocessing vessel and generating a signal indicative of the parameter. At least ne conductor is adapted to provide electrical communication between the liquid medium in the bioprocessing vessel and an external structure to achieve equipotential for reducing noise in the signal produced by the at least one sensor. Related apparatus and methods are also disclosed.Type: ApplicationFiled: May 11, 2021Publication date: July 20, 2023Inventors: Bastien Mairesse, Jean-Christophe Drugmand
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Patent number: 11680237Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.Type: GrantFiled: August 15, 2022Date of Patent: June 20, 2023Assignee: UNIVERCELLS TECHNOLOGIES S.A.Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
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Publication number: 20230017014Abstract: An apparatus for culturing cells with enhanced gas transfer and thermal regulation is provided. The apparatus includes a bioreactor with a cell culture bed, such as a fixed structured bed. A pump, such as an agitator, serves to pump liquid through the cell culture bed, and a container is provided for the agitator. A first conduit may be associated with the container, such as by being connected to it or adjacent an opening into it. The bioreactor may also include flow extenders to enhance the gas transfer to a liquid used as media to culture the cells, as well as optional thermoregulators. Related methods are also disclosed.Type: ApplicationFiled: December 2, 2020Publication date: January 19, 2023Inventors: Jean-Christophe Drugmand, Bart Karel Johan Heeran, Christophe Dumont, Xavier Gabet, José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez, Florent Van Hijfte
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Publication number: 20220396754Abstract: An apparatus for culturing cells includes a bioreactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed bed arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.Type: ApplicationFiled: August 15, 2022Publication date: December 15, 2022Inventors: José Castillo, Bastien Mairesse, Sebastien Jean-Pierre Michel Rodriguez
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Publication number: 20220235308Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.Type: ApplicationFiled: April 15, 2022Publication date: July 28, 2022Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem
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Publication number: 20220081664Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.Type: ApplicationFiled: November 30, 2021Publication date: March 17, 2022Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem
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Patent number: D1069155Type: GrantFiled: September 15, 2023Date of Patent: April 1, 2025Assignee: Quantoom Biosciences, société anonymeInventors: Anne De Lamotte, Bastien Mairesse, José Castillo