Patents by Inventor BASUDEB MAJI

BASUDEB MAJI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted delivery to beta cells
    Patent number: 12208140
    Abstract: The disclosure includes zinc prodrugs for targeted delivery of therapeutic, diagnostic or imaging agents to ?-cells and methods of use therefor. The disclosure also includes targeted delivery of small molecules to ?-cells that stabilize and activate CRISPR effector proteins comprising at least one destabilization domain, to enable CRISPR-based genome editing and transcriptional activation or repression in ?-cells.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: January 28, 2025
    Assignees: The Broad Institute, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Amit Choudhary, Debasish Manna, Miseon Lee, Bridget Wagner, Basudeb Maji
  • Inhibitors of RNA guided nucleases and uses thereof
    Patent number: 11787795
    Abstract: Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: October 17, 2023
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Amit Choudhary, Peng Wu, Basudeb Maji, Elisa Franco, Hari K. K. Subramanian
  • CRISPR protein inhibitors
    Patent number: 11760984
    Abstract: The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: September 19, 2023
    Inventors: Amit Choudhary, Kurt Cox, Basudeb Maji, Peng Wu, Hari Subramanian, Elisa Franco
  • METHODS AND COMPOSITIONS FOR OPTOCHEMICAL CONTROL OF CRISPR-CAS9
    Publication number: 20210317429
    Abstract: The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising CRISPR enzymes associated with at least one destabilization domain (DD) and photocaged stabilization ligands with at least one photocage molecule, along with compositions, systems and complexes involving such systems, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses thereof.
    Type: Application
    Filed: August 20, 2019
    Publication date: October 14, 2021
    Inventors: Amit CHOUDHARY, Debasish MANNA, Basudeb MAJI, Soumyashree Ashok GANGOPADHYAY
  • CRISPR-CAS SYSTEMS HAVING DESTABILIZATION DOMAIN
    Publication number: 20210222164
    Abstract: The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising guide-binding adaptors each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving such systems, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor.
    Type: Application
    Filed: June 29, 2017
    Publication date: July 22, 2021
    Inventors: Amit CHOUDHARY, Basudeb MAJI, Bernd ZETSCHE, Feng ZHANG
  • INHIBITORS OF RNA-GUIDED NUCLEASE TARGET BINDING AND USES THEREOF
    Publication number: 20210177832
    Abstract: Compositions and methods for inhibiting the activity of RNA-guided endonucleases, and methods for identifying such compositions are included. Methods of treatment using the inhibitory compounds, formulations and methods are also detailed, as well as control of nucleic acid editing systems and methods using said compounds.
    Type: Application
    Filed: August 20, 2019
    Publication date: June 17, 2021
    Inventors: Amit CHOUDHARY, Basudeb MAJI, Soumyashree Ashok GANGOPADHYAY, Miseon LEE, Mengchao SHI
  • TARGETED DELIVERY TO BETA CELLS
    Publication number: 20200384115
    Abstract: The disclosure includes zinc prodrugs for targeted delivery of therapeutic, diagnostic or imaging agents to ?-cells and methods of use therefor. The disclosure also includes targeted delivery of small molecules to ?-cells that stabilize and activate CRISPR effector proteins comprising at least one destabilization domain, to enable CRISPR-based genome editing and transcriptional activation or repression in ?-cells.
    Type: Application
    Filed: April 20, 2018
    Publication date: December 10, 2020
    Inventors: Amit CHOUDHARY, Debasish MANNA, Miseon LEE, Bridget WAGNER, Basudeb MAJI
  • CRISPR PROTEIN INHIBITORS
    Publication number: 20200354701
    Abstract: The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
    Type: Application
    Filed: October 31, 2018
    Publication date: November 12, 2020
    Inventors: Amit CHOUDHARY, Kurt COX, Basudeb MAJI, Peng WU, Hari SUBRAMANIAN, Elisa FRANCO
  • INHIBITORS OF RNA GUIDED NUCLEASES AND USES THEREOF
    Publication number: 20190263807
    Abstract: Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.
    Type: Application
    Filed: October 31, 2017
    Publication date: August 29, 2019
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: AMIT CHOUDHARY, PENG WU, BASUDEB MAJI, ELISA FRANCO, HARI K.K. SUBRAMANIAN