Abstract: The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: The present invention relates to a process for the preparation of low-viscosity polyisocyanate reaction products which contain allophanate groups, can be readily emulsified in water and contain activated groups which react, by polymerization, with ethylenically unsaturated compounds under the action of actinic radiation. The present invention furthermore relates to the products which can be prepared by the process according to the invention and their use.

Abstract: The present invention relates to a process for the preparation of highly reactive, low-viscosity and water-dilutable polyisocyanate reaction products which contain activated groups which react, by polymerization, with ethylenically unsaturated compounds under the action of actinic radiation. The present invention furthermore relates to a process for the preparation of such products and their use.

Abstract: The present invention relates to flame resistant moulding compositions comprising polycarbonates and graft polymers which, in addition to good flow properties, exhibit good (notched) impact strength and high chemical resistance with a UL94V-0 classification at 1.5 mm. These moulding compositions are particularly suitable for thin-walled housing parts in the electrical and electronics sector.

Abstract: Herbicide combinations (A)+(8), if appropriate in the presence of safeners, with an effective content of (A) broad-spectrum herbicides from the group (A 1) glufosinate (salts) and related compounds (A2) glyphosate (salts) and related compounds such as sulfosate, (A3) imidazolinones such as imazethapyr, imazapyr, imazaquin, imazamox or their salts and (A4) herbicidal azoles from the group of the protoporphyrinogen oxidase inhibitors (PPO inhibitors) and (A5) the hydroxybenzonitriles and (B) herbicides from the group consisting of (B0) one or more structurally different herbicides from the abovementioned group (A), (B1) foliar- and soil-acting herbicides which are effective against monocotyledonous and dicotyledonous harmful plants, (B2) predominantly foliar-acting herbicides which are effective against dicotyledonous harmful plants, (B3) predominantly foliar-acting herbicides which are effective against monocotyledonous harmful plants, and (B4) foliar- and soil-acting herbicides which are effective agai

Abstract: The invention relates to a method for producing medicaments that contain vardenafil hydrochloride, essentially as trihydrate in solid form, and to medicaments that can be obtained according to this method