Abstract: Provided are methods of identifying a cell that has been edited with a gene editing reagent. Also provided are methods of selecting a clone of a cell that has been identified as an edited cell containing a desired edit, as well as methods of gene editing that include such selecting of an edited clone. Methods of assessing the efficacy of gene editing reagents and methods employing a gene editing reagent efficacy assessment are also provided. The instant disclosure further provides kits for use in practicing the subject methods.