Abstract: A tool for material-removing machining of a workpiece has a proximal and a distal end, a shaft for connecting the tool to a drive in the region of the proximal end, and a tool head in the region of the distal end. Cutting elements on the tool head are configured such that they are capable of being introduced into the workpiece to be machined and they are capable of removing a material layer from the workpiece. The cutting elements also include at least one cutting tooth having a cutting tooth ridge and a cutting tooth root, and at least one cutting jaw having a cutting jaw ridge and a cutting jaw root. The ratio between the cutting tooth ridge and the cutting tooth root is smaller, in particular between two and ten times smaller, than the ratio between the cutting jaw ridge and the cutting jaw root.

Abstract: The present invention relates to a threading tool for producing a thread notch on a workpiece. The production may be both material-removing production and also chipless production. The threading tool comprises at least two regions, a distal machining region with a machining head, and a proximal shank region with a shank, which shank narrows toward the machining region via a shoulder. Furthermore, the threading tool according to the invention is designed such that at least one fluid duct extends through the shank, which at least one fluid duct opens out in the machining region.

Abstract: A method for milling a threading of a screw or tapped hole. The threading has a cross section in the shape of a triangle with a truncated crest. The method includes milling a first flank (V1) of at least one spire of the thread by a first comb (A) of a milling tool (F). The teeth of the first comb (A) are spaced in relation to one another by a first pitch (P1). Then milling a second flank (V2) of at least one other spire of the thread by a second comb (B) of the milling tool (F), wherein the teeth of the second comb (B) are spaced in relation to one another by a second pitch (P2) equal to the first pitch (P1) and offset from the teeth of the first comb (A) by a phase displacement (DP). Then milling a truncated portion (V3) of the crest by a third comb (C) of the milling tool (F).

Abstract: A method for milling a threading of a screw or tapped hole. The threading has a cross section in the shape of a triangle with a truncated crest. The method includes milling a first flank (V1) of at least one spire of the thread by a first comb (A) of a milling tool (F). The teeth of the first comb (A) are spaced in relation to one another by a first pitch (P1). Then milling a second flank (V2) of at least one other spire of the thread by a second comb (B) of the milling tool (F), wherein the teeth of the second comb (B) are spaced in relation to one another by a second pitch (P2) equal to the first pitch (P1) and offset from the teeth of the first comb (A) by a phase displacement (DP). Then milling a truncated portion (V3) of the crest by a third comb (C) of the milling tool (F).

Abstract: Compositions and methods for detecting various disorders with targeted microbubbles are disclosed. Specifically, microbubbles comprising glycoprotein Ib (GPIb), ligands for VCAM-1, and ligands for P-selectin such as PSGL-1 are disclosed. Also disclosed are methods for using targeted microbubbles to detect cardiovascular disease comprising administering the disclosed microbubbles to a subject and detecting the microbubbles in the vasculature using ultrasound.

Abstract: A method for generating an enhanced ultrasound image comprises intravenously administering to a subject a plurality of microbubbles of sufficient diameter to lodge in the microvasculature of a subject. An ultrasound image of a portion of the subject is generated wherein the image is enhanced by one or more of the administered microbubbles that has lodged in the microvasculature of the imaged portion. An ultrasound contrast media composition comprises a plurality of gas filled microbubbles. At least about 5% of the microbubbles have a diameter of at least about 4 microns (?m), and wherein the composition is suitable for intravenous administration. The administered microbubbles are of sufficient diameter to lodge in the microvasculature of a subject and can be used enhance ultrasound images small animal subjects including mice, rats and rabbits. The described methods and compositions can be used to enhance ultrasound images produced using high frequency ultrasound.