Patents by Inventor Beate Hirrlinger

Beate Hirrlinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic synthesis of optically active hydroxamic acids and their conversion to optically active primary amines by a lossen rearrangement
    Patent number: 6281003
    Abstract: A method is described for the preparation of optically active hydroxamic acids of the general formula wherein R1, R2 and R3 are different and are a cyclic or linear, aliphatic or aromatic, substituted or unsubstituted hydrocarbon radical which can optionally contain heteroatoms, said method being characterized in that a racemate of chiral amides, carboxylic acid esters or carboxylic acids of the general formula wherein R1, R2 and R3 are as defined above and X is —NH2, —OR or —OH, R being any organic radical, is reacted with hydroxylamine, NH2OH, in the presence of an acyltransferase, and the optically active hydroxamic acid (I) formed is then separated from the unconverted enantiomer of general formula (II). The resulting optically active hydroxamic acid can be converted to the corresponding optically active primary amines by a Lossen rearrangement.
    Type: Grant
    Filed: April 5, 1999
    Date of Patent: August 28, 2001
    Assignee: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e. V.
    Inventors: Beate Hirrlinger, Andreas Stolz, Hans-Joachim Knackmuss