Patents by Inventor Beatrice Claudia Langton

Beatrice Claudia Langton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-erbB-2 external domain: GP75
    Publication number: 20080248507
    Abstract: Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quantitate the level of gp75 in the biological fluids of mammals carrying a tumor burden. Further disclosed are recombinant, synthetically and otherwise biologically produced novel proteins and polypeptides which are encoded by the external domain DNA sequence of the c-erbB-2 oncogene (the gp75 gene) or fragments thereof. Such gp75 proteins and polypeptides are useful as vaccines, therapeutically in the treatment of cancer either alone or in combination with chemotherapeutic agents. Also disclosed are antibodies to such gp75 proteins and polypeptides which are useful diagnostically and therapeutically. Still further disclosed are test kits embodying the assays of this invention.
    Type: Application
    Filed: February 1, 2007
    Publication date: October 9, 2008
    Inventors: Miriam E.C. Hancock, John J. Monahan, Beatrice Claudia Langton
  • C-erbB-2 external domain: GP75
    Patent number: 7282345
    Abstract: Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quantitate the level of gp75 in the biological fluids of mammals carrying a tumor burden. Further disclosed are recombinant, synthetically and otherwise biologically produced novel proteins and polypeptides which are encoded by the external domain DNA sequence of the c-erbB-2 oncogene (the gp75 gene) or fragments thereof. Such gp75 proteins and polypeptides are useful as vaccines, therapeutically in the treatment of cancer either alone or in combination with chemotherapeutic agents. Also disclosed are antibodies to such gp75 proteins and polypeptides which are useful diagnostically and therapeutically. Still further disclosed are test kits embodying the assays of this invention.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: October 16, 2007
    Assignee: Schering AG
    Inventors: Miriam E. C. Hancock, John J. Monahan, Beatrice Claudia Langton
  • C-erbB-2 exrernal domain: gp75
    Publication number: 20020155527
    Abstract: Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quantitate the level of gp75 in the biological fluids of mammals carrying a tumor burden.
    Type: Application
    Filed: January 26, 2001
    Publication date: October 24, 2002
    Applicant: Triton BioSciences, Inc.
    Inventors: Susan G. Stuart, John J. Monahan, Beatrice Claudia Langton, Miriam E. C. Hancock, Lorrine A. Chao, Peter Bluford