Patents by Inventor Beatrice Yue

Beatrice Yue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Silencing of TGF? type II receptor expression by siRNA
    Patent number: 8067389
    Abstract: The present application is directed to siRNA-based silencing of the type II receptor of TGF?. siRNAs that target this receptor abrogate the receptor protein and transcript, TGF?-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGF? type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: November 29, 2011
    Assignee: The Broad of Trustees of the University of Illinois
    Inventors: Nalin M. Kumar, Beatrice Yue, Shahid Siddiqui, Asrar B. Malik, Jose S. Pulido
  • SILENCING OF TGF BETA TYPE II RECEPTOR EXPRESSION BY SIRNA
    Publication number: 20090318537
    Abstract: The present application is directed to siRNA-based silencing of the type II receptor of TGF?. siRNAs that target this receptor abrogate the receptor protein and transcript, TGF?-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGF? type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.
    Type: Application
    Filed: July 20, 2009
    Publication date: December 24, 2009
    Inventors: NALIN M. KUMAR, BEATRICE YUE, SHAHID SIDDIQUI, ASRAR B. MALIK, JOSE S. PULIDO
  • Silencing of tgf-beta receptor type II expression by sirna
    Publication number: 20060229266
    Abstract: The present application is directed to siRNA-based silencing of the type II receptor of TGF?. siRNAs that target this receptor abrogate the receptor protein and transcript, TGF?-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGF? type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.
    Type: Application
    Filed: August 10, 2004
    Publication date: October 12, 2006
    Inventors: Nalin Kumar, Beatrice Yue, Shahid Siddiqui, Asrar Malik, Jose Pulido