Patents by Inventor Beatrix BALI

Beatrix BALI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE PRODUCTION OF LUMATEPERONE AND ITS SALTS
    Publication number: 20230331727
    Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X = I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.
    Type: Application
    Filed: February 16, 2023
    Publication date: October 19, 2023
    Applicant: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Gábor BERECZ, Bálint NYULASI, Mátyás MILEN, Gyula SIMIG, András MRAVIK, Gábor NÉMETH, Adrienn KESZTHELYI, Beatrix BALI, Balázs VOLK, László SZLÁVIK, Zoltán VARGA, Daniel ULEJ
  • Method for the production of lumateperone and its salts
    Patent number: 11655251
    Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X=I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: May 23, 2023
    Assignee: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Gábor Berecz, Bálint Nyulasi, Mátyás Milen, Gyula Simig, András Mravik, Gábor Németh, Adrienn Keszthelyi, Beatrix Bali, Balázs Volk, László Szlávik, Zoltán Varga, Daniel Ulej
  • METHOD FOR THE PRODUCTION OF LUMATEPERONE AND ITS SALTS
    Publication number: 20210070755
    Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X?I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.
    Type: Application
    Filed: November 27, 2018
    Publication date: March 11, 2021
    Applicant: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Gábor BERECZ, Bálint NYULASI, Mátyás MILEN, Gyula SIMIG, András MRAVIK, Gábor NÉMETH, Adrienn KESZTHELYI, Beatrix BALI, Balázs VOLK, László SZLÁVIK, Zoltán VARGA, Daniel ULEJ