Patents by Inventor Beatrix Merla

Beatrix Merla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8586755
    Abstract: Substituted nicotinamides, processes for their preparation, medicaments comprising these compounds and methods of using these compounds to treat pain, epilepsy, urinary incontinence, anxiety, dependency, mania, bipolar disorders, migraine, cognitive diseases, and/or dystonia-associated dyskinesias.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: November 19, 2013
    Assignee: Grünenthal GmbH
    Inventors: Sven Kühnert, Beatrix Merla, Gregor Bahrenberg, Wolfgang Schröder
  • Patent number: 8367700
    Abstract: The invention relates to substituted tetrahydroisoquinolinyl-4-oxobutyric acid amides, methods for the preparation thereof, medicinal products containing these compounds and the use of these compounds for the preparation of medicinal products.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: February 5, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Sven Kühnert, Gregor Bahrenberg, Beatrix Merla, Klaus Schiene, Wolfgang Schröder
  • Patent number: 8288424
    Abstract: Substituted tetrahydroimidazopyridine compounds corresponding to formula I: in which R1, R2 and R3 have defined meanings, processes for preparing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting pain, epilepsy, migraine, anxiety or urinary incontinence.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: October 16, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Stefan Oberboersch, Sven Kuehnert, Gregor Bahrenberg, Achim Kless
  • Patent number: 8263598
    Abstract: Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R1, R2, R3, R4, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: September 11, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Stefan Oberboersch, Ruth Jostock, Michael Engels, Stefan Schunk, Melanie Reich, Sabine Hees
  • Patent number: 8247573
    Abstract: The invention relates to substituted N-(2-mercaptopyridin-3-yl)amides, methods for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: August 21, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Sven Kühnert, Beatrix Merla, Achim Kless, Gregor Bahrenberg, Wolfgang Schröder
  • Publication number: 20120184550
    Abstract: Substituted nicotinamides, processes for their preparation, medicaments comprising these compounds and methods of using these compounds to treat pain, epilepsy, urinary incontinence, anxiety, dependency, mania, bipolar disorders, migraine, cognitive diseases, and/or dystonia-associated dyskinesias.
    Type: Application
    Filed: March 30, 2012
    Publication date: July 19, 2012
    Applicant: GRUNENTHAL GMBH
    Inventors: SVEN Kühnert, Beatrix Merla, Gregor Bahrenberg, Wolfgang Schröder
  • Patent number: 8178535
    Abstract: Substituted sulfonamide compounds corresponding to the formula I? wherein m, n, p, X, Y, Z, R1, RA and RB have specified meanings, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these substituted sulfonamide compounds for the treatment and/or inhibition of pain or other conditions.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: May 15, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Stefan Oberboersch, Ruth Jostock, Michael Engels, Stefan Schunk, Melanie Reich, Sabine Hees
  • Patent number: 8178684
    Abstract: The invention relates to substituted nicotinamides, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: May 15, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Sven Kühnert, Beatrix Merla, Gregor Bahrenberg, Wolfgang Schröder
  • Patent number: 8158628
    Abstract: Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R1, R2a, R2b, R3a, R3b, R4, R8, R9a, R9b, R10, R11, A, B, W1, W2 and W3 have the meanings defined herein, pharmaceutical compositions containing such compounds, a method for the preparation of such compounds, and the use of such compounds for treating or inhibiting various types of pain and/or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: April 17, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Stefan Oberboersch, Melanie Reich, Stefan Schunk, Ruth Jostock, Sabine Hees, Michael Engels, Tieno Germann, Edward Bijsterveld
  • Patent number: 8124788
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the production of pharmaceuticals, and particularly for the treatment of pain.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: February 28, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Stefan Oberboersch, Bernd Sundermann, Werner Englberger, Hagen-Heinrich Hennies, Babette-Yvonne Koegel, Stephan Schunk, Heinz Graubaum
  • Patent number: 8119633
    Abstract: Substituted sulfonamide compounds corresponding to formula I pharmaceutical compositions comprising them, a process for preparing them, and the use of such compounds to treat or inhibit pain and other disorders or disease states.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: February 21, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Stefan Oberboersch, Melanie Reich, Bernd Sundermann, Werner Englberger, Timo Struenker, Ruth Jostock, Sabine Hees, Edward Bijsterveld, Fritz Theil, Heinz Graubaum
  • Patent number: 8106055
    Abstract: Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments for the treatment of pain and various other conditions.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: January 31, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Oberboersch, Melanie Reich, Bernd Sundermann, Utz-Peter Jagusch, Beatrix Merla, Stefan Schunk, Werner Englberger, Timo Struenker, Hagen-Heinrich Hennies, Edward Bijsterveld, Fritz Theil, Heinz Graubaum
  • Patent number: 8084470
    Abstract: Substituted nicotinamide compounds corresponding to formula I a process for their preparation, pharmaceutical compositions containing these compounds, and the use thereof for the treatment or inhibition conditions such as pain, epilepsy, migraine, anxiety states, or urinary incontinence.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: December 27, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Sven Kuehnert, Robert Frank, Dagmar Kaulartz, Wolfgang Schroeder, Gregor Bahrenberg, Klaus Schiene
  • Patent number: 8058475
    Abstract: Novel cyclohexylmethyl compounds corresponding to formula I wherein R1, R2, R3, R4 and R5, have the meanings given in the description. Pharmaceutical formulations containing these compounds, as well as a processes for preparing these compounds and related methods of treatment are also provided.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: November 15, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Oberboersch, Beatrix Merla, Bernd Sundermann, Werner Englberger, Hagen-Heinrich Hennies, Achim Kless, Petra Bloms-Funke, Babette-Yvonne Koegel, Heinze Graubaum
  • Patent number: 8017772
    Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: September 13, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
  • Patent number: 7977360
    Abstract: The present invention relates to substituted benzo[d]isoxazol-3-yl-amine compounds, methods for their production, medicaments containing these compounds and the use of these compounds to produce medicaments.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: July 12, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Beatrix Merla, Melanie Reich, Ruth Jostock
  • Patent number: 7879858
    Abstract: Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I a process for producing such compounds; and a method of using such compounds to treat or inhibit various disorders or disease states including pain, depression and anxiety.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: February 1, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Thomas Christoph, Stefan Oberboersch, Klaus Schiene, Gregor Bahrenberg, Robert Frank, Sven Kuehnert, Wolfgang Schroeder
  • Patent number: 7842812
    Abstract: Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides, a process for the production thereof, pharmaceutical preparations containing these compounds and the use of these compounds in pharmaceutical preparations for treatment or inhibition of withdrawal symptoms, memory disorders, neurodegenerative diseases, epilepsy, cardiovascular disorders, water retention, intestinal motility disorders, urinary incontinence, anorexia, tinnitus, pruritus, depression, sexual dysfunction, airways diseases, food intake disorders, or type II (non-insulin-dependent) diabetes, or for anxiolysis, diuresis, suppression of the urinary reflex, reducing the addictive potential of opioids, modulating locomotor activity, influencing the cardiovascular system, or regulating electrolyte balance.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: November 30, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Beatrix Merla, Corinna Sundermann, Utz-Peter Jagusch, Werner Englberger, Hagen-Heinrich Hennies, Babette-Yvonne Koegel
  • Publication number: 20100234387
    Abstract: Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R1, R2a, R2b, R3a, R3b, R4, R8, R9a, R9b, R10, R11, A, B, W1, W2 and W3 have the meanings defined herein, pharmaceutical compositions containing such compounds, a method for the preparation of such compounds, and the use of such compounds for treating or inhibiting various types of pain and/or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).
    Type: Application
    Filed: March 4, 2010
    Publication date: September 16, 2010
    Applicant: Gruenethal GmbH
    Inventors: Beatrix MERLA, Stefan Oberboersch, Melanie Reich, Stefan Schunk, Ruth Jostock, Sabine Hees, Michael Engels, Tieno Germann, Edward Bijsterveld
  • Publication number: 20100234429
    Abstract: The invention relates to substituted nicotinamides, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments.
    Type: Application
    Filed: March 10, 2010
    Publication date: September 16, 2010
    Applicant: GRÜNENTHAL GMBH
    Inventors: Sven Kühnert, Beatrix Merla, Gregor Bahrenberg, Wolfgang Schröder