Patents by Inventor Beatus Ofenloch-Haehnle
Beatus Ofenloch-Haehnle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959914Abstract: The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.Type: GrantFiled: January 29, 2019Date of Patent: April 16, 2024Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Tatsuki Takakura, Kenta Imai, Takaaki Hagiwara, Yoshihiro Yamashita, Taku Sakazume, Beatus Ofenloch-Haehnle, Michaela Windfuhr, Ursula Pauselius-Fuchs, Rita Haerteis
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Patent number: 11215627Abstract: In conventional automatic analyzers, there have been instances where, when a plurality of associated items are analyzed as a set item, there is high variation in the analysis data obtained using the set item, leading to a need for improvement of analysis precision. The present invention comprises performing, in mutual association, a set of preparation steps to carry out until it is time to analyze an unknown sample, the set of preparation steps including a pre-preparation step in which stirring, etc., is performed when an analysis reagent kit is mounted on the analyzer, and a step for correcting a standard curve in which correction samples that correspond to analysis items are used. This makes it possible to perform analysis after the preparation states of a plurality of analysis reagent kits are collected as needed, enabling high-precision analysis of a set item.Type: GrantFiled: July 1, 2016Date of Patent: January 4, 2022Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Kenta Imai, Toshiharu Suzuki, Shigeki Matsubara, Takayuki Sugime, Shunsuke Sasaki, Elke Faatz, Beatus Ofenloch-Haehnle
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Publication number: 20200240981Abstract: The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.Type: ApplicationFiled: January 29, 2019Publication date: July 30, 2020Inventors: Tatsuki TAKAKURA, Kenta IMAI, Takaaki HAGIWARA, Yoshihiro YAMASHITA, Taku SAKAZUME, Beatus OFENLOCH-HAEHNLE, Michaela WINDFUHR, Ursula PAUSELIUS-FUCHS, Rita HAERTEIS
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Publication number: 20180246133Abstract: In conventional automatic analyzers, there have been instances where, when a plurality of associated items are analyzed as a set item, there is high variation in the analysis data obtained using the set item, leading to a need for improvement of analysis precision. The present invention comprises performing, in mutual association, a set of preparation steps to carry out until it is time to analyze an unknown sample, the set of preparation steps including a pre-preparation step in which stirring, etc., is performed when an analysis reagent kit is mounted on the analyzer, and a step for correcting a standard curve in which correction samples that correspond to analysis items are used. This makes it possible to perform analysis after the preparation states of a plurality of analysis reagent kits are collected as needed, enabling high-precision analysis of a set item.Type: ApplicationFiled: July 1, 2016Publication date: August 30, 2018Inventors: Kenta IMAI, Toshiharu SUZUKI, Shigeki MATSUBARA, Takayuki SUGIME, Shunsuke SASAKI, Elke FAATZ, Beatus OFENLOCH-HAEHNLE
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Publication number: 20100136519Abstract: The invention concerns a process for the immunological determination of a specific antibody in a fluid sample. The process involves incubating the fluid sample in the presence of a solid phase with two antigens directed against the antibody whose presence is to be determined; the first antigen carries at least one marker group, while the second is either (a) bonded to the solid phase or (b) present in a form in which it can bond with the solid phase, and betrays the presence of the antibody being sought by showing the presence of the marker group in the solid phase and/or in the fluid phase. The proposed process is characterised by the fact that at least one of the two antigens has several epitopic regions which react with the antibody to be determined.Type: ApplicationFiled: October 27, 2009Publication date: June 3, 2010Applicant: Roche Diagnostics GmbHInventors: Ursula-Henrike Wienhues, Cornelia Kruse-Müller, Eva Höss, Elke Faatz, Beatus Ofenloch-Hähnle, Christoph Seidel, Michael Wiedmann
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Patent number: 7629295Abstract: The invention concerns a method for the immunological determination of a specific antibody in a sample liquid in which the sample liquid is incubated in the presence of a solid phase with two antigens directed against the antibody to be determined of which the first antigen carries at least one marker group and the second antigen is (a) bound to the solid phase or (b) is present in a form capable of binding to the solid phase and the antibody to be determined is detected by determining the marker group in the solid phase or/and in the liquid phase characterized in that at least one of the two antigens contains several epitope regions which react with the antibody to be determined.Type: GrantFiled: July 7, 2003Date of Patent: December 8, 2009Assignee: Roche Diagnostics GmbHInventors: Ursula-Henrike Wienhues, Cornelia Kruse-Müller, Eva Höss, Elke Faatz, Beatus Ofenloch-Hähnle, Christoph Seidel, Michael Wiedmann
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Patent number: 6613530Abstract: The invention concerns a method for the immunological determination of a specific antibody in a sample liquid in which the sample liquid is incubated in the presence of a solid phase with two antigens directed against the antibody to be determined of which the first antigen carries at least one marker group and the second antigen is (a) bound to the solid phase or (b) is present in a form capable of binding to the solid phase and the antibody to be determined is detected by determining the marker group in the solid phase or/and in the liquid phase characterized in that at least one of the two antigens contains several epitope regions which react with the antibody to be determined.Type: GrantFiled: January 24, 1997Date of Patent: September 2, 2003Assignee: Roche Diagnostics GmbHInventors: Ursula-Henrike Wienhues, Cornelia Kruse-Müller, Eva Höss, Elke Faatz, Beatus Ofenloch-Hähnle, Christoph Seidel, Michael Wiedmann
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Patent number: 6489131Abstract: The invention concerns a method for the determination of an analyte in which rheumatoid factors or rheumatoid-factor-like substances are added as an interference reducing reagent to reduce of avoid a hook effect. The invention in addition concerns suitable reagent kits for carrying out the method.Type: GrantFiled: May 6, 1999Date of Patent: December 3, 2002Assignee: Roche Diagnostics GmbHInventors: Rainer Wehner, Frederic Donie, Beatus Ofenloch-Hähnle
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Patent number: 5601824Abstract: Compound of the general formula ##STR1## wherein R is an ester-activating group, m and n are identical or different and 0-6, p =0, 2-4, and q and s=1, p=0 if s=0 and p=2-4 if s=1. The compound is novel and suitable for the reproducible coupling of immunological substances at a high yield.Type: GrantFiled: February 23, 1996Date of Patent: February 11, 1997Assignee: Boehringer Mannheim GmbHInventors: Eva Hoess, Erasmus Huber, Christine Markert-Hahn, Beatus Ofenloch-Haehnle
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Patent number: 5519142Abstract: Compound of the general formula ##STR1## wherein R is an ester-activating group, m and n are identical or different and 0-6, p=0, 2-4, and q and s=1, p=0 if s=0 and p=2-4 if s=1. The compound is novel and suitable for the reproducible coupling of immunological substances at a high yield.Type: GrantFiled: March 29, 1994Date of Patent: May 21, 1996Assignee: Boehringer Mannheim GmbHInventors: Eva Hoess, Erasmus Huber, Christine Markert-Hahn, Beatus Ofenloch-Haehnle
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Patent number: 5514559Abstract: Novel conjugate of the general formulaA--L.sub.1 --L.sub.2 --Bwherein A and B are the substances to be coupled selected from the groups of haptens, proteins, polysaccharides, soluble polystyrenes, or peptides, L.sub.1 and L.sub.2 are trivalent linkers and L.sub.1 and L.sub.2 are bound via two thioether. They can be used in immunological assays and exhibit an improved storage stability.Type: GrantFiled: March 29, 1994Date of Patent: May 7, 1996Assignee: Boehringer Mannheim GmbHInventors: Christine Markert-Hahn, Beatus Ofenloch-Haehnle, Eva Hoess, Erasmus Huber