Abstract: Described are improved methods for treating solid tumors, such as malignant gliomas, with a dual approach utilizing a CAR-T immunotherapy and a viral oncolytic therapy.

Abstract: The present invention relates to methods of removing a lesion from a patient. A method of removing a lesion from a patient includes positioning wire loops of a probe device relative to the lesion. The wire loops are simultaneously rotated and expanded to cut material from the lesion. Irrigation fluid is supplied, via the probe device, to irrigate the material cut from the lesion. The supplied irrigation fluid is aspirated, via the probe device, to facilitate removal of the material cut from the lesion.

Abstract: An improved method of treating cancers with engineered T cells is described.

Abstract: The present invention relates to methods of removing a lesion from a patient. A method of removing a lesion from a patient includes positioning wire loops of a probe device relative to the lesion. The wire loops are simultaneously rotated and expanded to cut material from the lesion. Irrigation fluid is supplied, via the probe device, to irrigate the material cut from the lesion. The supplied irrigation fluid is aspirated, via the probe device, to facilitate removal of the material cut from the lesion.

Abstract: A surgical device for use in removing a lesion from a brain includes a first tube, a second tube disposed within the first tube, a sleeve that encloses a portion of the first tube, wire loops attached to a distal end of the first tube, a loop expander and rotation mechanism drivingly coupled with the wire loops, an aspiration port, and an irrigation port. The loop expander and rotation mechanism is operable to expand the wire loops while rotating the wire loops relative to the first tube and contract the wire loops while rotating the wire loops relative to the first tube. Cut tissue is aspirated via the aspiration port. Irrigation fluid is supplied to irrigate the cut tissue via the irrigation port.

Abstract: An improved method of treating cancers with engineered T cells is described.

Abstract: The present invention relates to surgical devices and related methods of use. In particular, the present invention relates to surgical devices used for contacting and treating deeply seated areas of the brain.

Abstract: Surgical devices and methods are configured to access areas of the brain while minimizing brain damage. A brain probe device for removing a lesion from a brain includes a cannula fixable to the skull to align the cannula with the lesion, a tubular stem within the cannula configured to be advanced to the lesion, and a rotatable cutting tube within the tubular stem. Expandable wire loops configured to cut tissue are attached to the distal end of the tubular stem. A loop expander and rotation motor mechanism is operably linked to the wire loops and configured to cause rotation and variable outward expansion of the wire loops. Tissue cut by the wire loops is removed through slots and a central lumen of the tubular stem. The cutting tube is rotatable to sever tissue drawn into the slots into smaller fragments that are removed through the central lumen via aspiration.

Abstract: The present invention relates to surgical devices and related methods of use. In particular, the present invention relates to surgical devices used for contacting and treating deeply seated areas of the brain.

Abstract: The present invention relates to multiple-tract cannula devices and related methods of use. In certain embodiments, the present invention relates to multiple-tract cannula devices used for contacting and treating brain tissue (e.g., delivering pharmaceutical agents to brain tissue).

Abstract: The present invention relates to implantable devices, and particularly implantable devices that may be positioned, for example, into the sphenoid sinus or sella turcica of a subject. In certain embodiments, the implantable devices comprise a center plate and a plurality of protruding arms extending from the center plate, both of which may be composed of bioresorbable material. In particular embodiments, the implantable devices are configured to help reconstruct the sellar floor after it has been damaged in order to prevent cerebrospinal fluid leaks.

Abstract: The present invention relates to surgical devices and related methods of use. In particular, the present invention relates to surgical devices used for contacting and treating deeply seated areas of the brain.

Abstract: Surgical forceps with integral suction are disclosed. The forceps include first and second elongated members movably interconnected so that the tips are juxtaposed for movement between spaced apart and clamping positions. One of the members has a channel extending from a suction orifice at the tip to a suction adapter, and a bypass port in the inward facing sidewall which admits ambient air to the channel. The other member has a suction control plug juxtaposed on its inward facing side for insertion into the bypass port to reduce the ambient air admitted to the channel. The forceps members are resiliently deformable and the suction control port and plug are arranged so that, with the forceps tips remaining in contact, the port is closed by compressing the members together and is opened by relaxing the compression. Movement of the elongated members into the clamping position using the same action as normally used with forceps, and then applying compression, controls suction through the suction orifice.