Patents by Inventor Behnam Javanmardi
Behnam Javanmardi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240001361Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.Type: ApplicationFiled: September 18, 2023Publication date: January 4, 2024Inventors: Sebastian Bohm, Alex Aravanis, Alexander Hsiao, Behnam Javanmardi, Tarun Kumar Khurana, Hai Quang Tran, Majid Aghababazadeh, M. Shane Bowen, Boyan Boyanov, Dale Buermann
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Patent number: 11786898Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.Type: GrantFiled: March 13, 2020Date of Patent: October 17, 2023Assignee: ILLUMINA, INC.Inventors: Sebastian Bohm, Alex Aravanis, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Hai Quang Tran, Majid Aghababazadeh, M. Shane Bowen, Boyan Boyanov, Dale Buermann
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Publication number: 20230145389Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.Type: ApplicationFiled: December 22, 2022Publication date: May 11, 2023Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
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Patent number: 11590494Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.Type: GrantFiled: June 6, 2019Date of Patent: February 28, 2023Assignee: ILLUMINA, INC.Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
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Publication number: 20220323956Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.Type: ApplicationFiled: June 24, 2022Publication date: October 13, 2022Inventors: Helmy A. Eltoukhy, Tarun Khurana, Behnam Javanmardi, Poorya Sabounchi, Majid Aghababazadeh
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Patent number: 11400446Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.Type: GrantFiled: August 1, 2019Date of Patent: August 2, 2022Assignee: ILLUMINA, INC.Inventors: Helmy A. Eltoukhy, Tarun Khurana, Behnam Javanmardi, Poorya Sabounchi, Majid Aghababazadeh
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Patent number: 11390864Abstract: In the examples set forth herein, nucleic acid extraction materials are capable of selectively extracting cell free nucleic acids, including cell free DNA, directly from whole blood samples or plasma. Also included are methods of making and using the nucleic acid extraction materials. One example of a nucleic acid extraction material includes a substrate. This example of the nucleic acid extraction material also includes a polycation bonded to at least a portion of a surface of the substrate. In this example, the polycation consists of a polymer of a quaternized monomer selected from the group consisting of a quaternized 1-vinylimidazole monomer and a quaternized dimethylaminoethyl methacrylate monomer, or a copolymer of a neutral monomer and the quaternized monomer.Type: GrantFiled: June 28, 2018Date of Patent: July 19, 2022Assignees: Illumina, Inc., Illumina Cambridge LimitedInventors: Brian D. Mather, Cyril Delattre, Tarun Kumar Khurana, Yir-Shyuan Wu, Pallavi Daggumati, Behnam Javanmardi, Filiz Gorpe-Yasar, Sebastien Georg Gabriel Ricoult, Xavier von Hatten, Daniel Leonard Fuller
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Patent number: 11174513Abstract: A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.Type: GrantFiled: May 7, 2019Date of Patent: November 16, 2021Assignee: Illumina, Inc.Inventors: Poorya Sabounchi, Behnam Javanmardi, Tarun Khurana, Philip Paik, Yan-You Lin
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Publication number: 20200325467Abstract: An example of a nucleic acid extraction material includes a substrate. The nucleic acid extraction material also includes a polycation bonded to at least a portion of a surface of the substrate. The polycation consists of a polymer of a quaternized monomer selected from the group consisting of a quaternized 1-vinylimidazole monomer and a quaternized dimethylaminoethyl methacrylate monomer, or a copolymer of a neutral monomer and the quaternized monomer.Type: ApplicationFiled: June 28, 2018Publication date: October 15, 2020Inventors: Brian D. Mather, Cyril Delattre, Tarun Kumar Khurana, Yir-Shyuan Wu, Pallavi Daggumati, Behnam Javanmardi, Filiz Gorpe-Yasar, Sebastien Georg Gabriel Ricoult, Xavier von Hatten, Daniel Leonard Fuller
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Patent number: 10767219Abstract: The disclosed embodiments concern microfluidic cartridges for detecting biological reactions. In some embodiments, the microfluidic cartridges are configured to perform sequencing operations on a nucleic acid sample. In one aspect, a microfluidic cartridge includes a stack of fluidics layers defining channels and valves for processing the nucleic acid sample to be sequenced, and a solid state CMOS biosensor integrated in the stack. The biosensor has an active area configured to detect signals of biological reactions, wherein substantially all of the active area is available for reagent delivery and illumination during operation. In another aspect, a microfluidic cartridge includes: (a) a flow cell including a reaction site area encompassing one or more reaction sites; (b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area; (c) a biosensor having an active area configured to detect signals of biological reactions in the reaction site area.Type: GrantFiled: March 11, 2015Date of Patent: September 8, 2020Assignee: ILLUMINA, INC.Inventors: Poorya Sabounchi, Behnam Javanmardi, Tarun Khurana, Philip Paik, Yan-You Lin
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Publication number: 20200206737Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.Type: ApplicationFiled: March 13, 2020Publication date: July 2, 2020Inventors: Sebastian Bohm, Alex Aravanis, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Hai Quang Tran, Majid Aghababazadeh, M. Shane Bowen, Boyan Boyanov, Dale Buermann
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Patent number: 10596569Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.Type: GrantFiled: June 3, 2015Date of Patent: March 24, 2020Assignee: ILLUMINA, INC.Inventors: Sebastian Bohm, Alex Aravanis, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Hai Quang Tran, Majid Aghababazadeh, M. Shane Bowen, Boyan Boyanov, Dale Buermann
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Publication number: 20190351414Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.Type: ApplicationFiled: August 1, 2019Publication date: November 21, 2019Inventors: Helmy A. Eltoukhy, Tarun Khurana, Behnam Javanmardi, Poorya Sabounchi, Majid Aghababazadeh
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Patent number: 10427155Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.Type: GrantFiled: May 27, 2015Date of Patent: October 1, 2019Assignee: Illumina, Inc.Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
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Publication number: 20190283024Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.Type: ApplicationFiled: June 6, 2019Publication date: September 19, 2019Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
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Patent number: 10406519Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.Type: GrantFiled: March 26, 2018Date of Patent: September 10, 2019Assignee: ILLUMINA, INC.Inventors: Helmy A. Eltoukhy, Tarun Khurana, Behnam Javanmardi, Poorya Sabounchi, Majid Aghababazadeh
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Publication number: 20190264276Abstract: A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.Type: ApplicationFiled: May 7, 2019Publication date: August 29, 2019Inventors: Poorya Sabounchi, Behnam Javanmardi, Tarun Khurana, Philip Paik, Yan-You Lin
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Publication number: 20180214871Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.Type: ApplicationFiled: March 26, 2018Publication date: August 2, 2018Inventors: Helmy A. Eltoukhy, Tarun Khurana, Behnam Javanmardi, Poorya Sabounchi, Majid Aghababazadeh
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Patent number: 9937497Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.Type: GrantFiled: July 8, 2016Date of Patent: April 10, 2018Assignee: ILLUMINA, INC.Inventors: Helmy A. Eltoukhy, Tarun Khurana, Behnam Javanmardi, Poorya Sabounchi, Majid Aghababazadeh
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Patent number: 9839910Abstract: Fluidic cartridge including a liquid container having a reservoir configured to hold a liquid. The liquid container includes an interior surface. The fluidic cartridge also includes a transfer tube that extends from the interior surface to a distal end. The distal end includes a fluidic port that is in flow communication with the reservoir through the transfer tube. The transfer tube has a piercing segment that includes the distal end. The fluidic cartridge also includes a movable seal that is engaged to the piercing segment of the transfer tube and configured to slide along the piercing segment from a closed position to a displaced position during a mating operation. The movable seal blocks flow of the liquid through the fluidic port when in the closed position. The piercing segment extends through the movable seal when in the displaced position.Type: GrantFiled: September 18, 2015Date of Patent: December 12, 2017Assignee: Illumina, Inc.Inventors: Paul O. Ramstad, Majid Aghababazadeh, Behnam Javanmardi