Abstract: The present disclosure provides dimeric antigen receptors (DAR) constructs that bind a CD20 target antigen, where the DAR construct comprises a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain. The two polypeptide chains that make up the dimeric antigen receptors can dimerize to form an antigen binding domain. The dimeric antigen receptors have antibody-like properties as they bind specifically to a target antigen. The dimeric antigen receptors can be used for directed cell therapy.

Abstract: The present disclosure provides dimeric antigen receptors (DAR) constructs that bind a BCMA target antigen, where the DAR construct comprises a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain. The two polypeptide chains that make up the dimeric antigen receptors can dimerize to form an antigen binding domain. The dimeric antigen receptors have antibody-like properties as they bind specifically to a target antigen. The dimeric antigen receptors can be used for directed cell therapy.

Abstract: The present disclosure provides dimeric antigen receptors (DAR) constructs comprising a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain. The two polypeptide chains that make up the dimeric antigen receptors can dimerize to form an antigen binding domain. The dimeric antigen receptors have antibody-like properties as they bind specifically to a target antigen. The dimeric antigen receptors can be used for directed cell therapy.

Abstract: A water-dispersible amphoteric polyurethane and a preparation method therefor. The water-dispersible amphoteric polyurethane is prepared from a polyisocyanate compound, a polyol compound, a dial compound having an anionic group or a potential anionic group, a compound having a tertiary or quaternary amine cationic group at least having two active H functional groups and a polyamine compound having a polyoxyethylene group. During preparation, the feeding order of the dial compound and the compound having a tertiary or low-molecular quaternary amine cationic group is controlled, and then neutralization and chain extension are performed, to obtain the target product. Also disclosed is a use of the water-dispersible amphoteric polyurethane in reinforcing concrete, wherein the water-dispersible amphoteric polyurethane is present in an amount of 0.1% to 5%, based on the total weight of the concrete.