Abstract: A B7-H3 targeting antibody-drug conjugate, and a preparation method therefor and use thereof. Provided is the antibody-drug conjugate as shown in formula I. The compound has a good targeting property, good inhibitory effect on tumor cells positively expressing B7-H3, and good druggability and safety. The present antibody-drug conjugate has an inhibitory effect against B7-H3, and also a good inhibitory effect against at least one of NCI-N87, A375, LN-229, PA-1, MDA-MB-468, Calu-6 and HS-700T cells.

Abstract: This disclosure relates to techniques for determining a dissociation constant of a reservoir that includes methane hydrate and generating a methane hydrate production output that may be used to inform certain decisions related to processing a reservoir that includes the methane hydrate. In some embodiments, the techniques may include determining the dissociation constant using multiple pressures measured at different flowrates at time points from within a wellbore.

Abstract: A TROP2 targeting antibody-drug conjugate, and a preparation method and use therefor. The antibody-drug conjugate is shown in formula I. Said type of compound has a good targeting property, a good inhibitory effect on tumor cells positively expressing TROP2, and good druggability and high safety. The present antibody drug conjugate has an inhibitory effect on TROP2, and also a good inhibitory effect on at least one of NCI-N87, MDA-MB-468 and BXPC3 cells.

Abstract: An antibody-drug conjugate, and an intermediate thereof, a preparation method therefor, and an application thereof. Provided is an antibody-drug conjugate as represented by formula I. The compound has good targetability, has a good inhibitory effect on HER3-positive tumor cells, and has good druggability and high safety. The antibody-drug conjugate has an inhibitory effect on HER3, has an inhibitory effect on SK-BR-3 and SW620 cells, and also has a good inhibitory effect on at least one of 22Rv1, LNCaP, NCI-H820, OVCAR-8, and HCC827 cells.

Abstract: A data processing method includes receiving a message related to performance of a storage device, the message including an indicator value regarding the performance in a first time period, and a timestamp associated with the first time period. A status record of the storage device, including the number of received indicator values in a second time period including the first time period, is determined based on the timestamp, wherein the number of the received indicator values is less than a threshold number and can be updated based on the indicator value. The performance in the second time period can be determined based on the indicator value and the received indicator values in response to determining that the updated number of the received indicator values reaches the threshold number. Thus, the performance of the storage device can be quickly and accurately determined, and the consumption of computing resources is reduced.

Abstract: Disclosed are an antibody-drug conjugate (ADC), an intermediate thereof, a preparation method therefor and an application thereof. The present invention provides an ADC. A structural general formula thereof is Ab-(L3-L2-L1-D)m. The ADC has better biological activity, stability, and uniformity, has reduced toxic and side effects, and has a faster release rate of enzyme cutting in tumor cells. The use of the novel ADC can achieve a wide application of a cytotoxic drug particularly camptothecin in the field of ADCs in treating tumor patients resistant to microtubule ADC.

Abstract: An application of an antibody conjugate in the preparation of a drug for treating CD30 positive tumors, which is characterized in that: the antibody conjugate is F0002-ADC; the general formula of the structural thereof is Ab-Lm-Yn; and the CD30-positive tumors are CD30-positive tumors that express a multidrug resistance gene 1. In addition, a pharmaceutical combination and a pharmaceutical composition containing the antibody conjugate, which may be applied to the preparation of a drug used for treating CD30-positive tumors.

Abstract: A data processing method includes receiving a message related to performance of a storage device, the message including an indicator value regarding the performance in a first time period, and a timestamp associated with the first time period. A status record of the storage device, including the number of received indicator values in a second time period including the first time period, is determined based on the timestamp, wherein the number of the received indicator values is less than a threshold number and can be updated based on the indicator value. The performance in the second time period can be determined based on the indicator value and the received indicator values in response to determining that the updated number of the received indicator values reaches the threshold number. Thus, the performance of the storage device can be quickly and accurately determined, and the consumption of computing resources is reduced.

Abstract: A data processing method includes receiving a message related to performance of a storage device, the message including an indicator value regarding the performance in a first time period, and a timestamp associated with the first time period. A status record of the storage device, including the number of received indicator values in a second time period including the first time period, is determined based on the timestamp, wherein the number of the received indicator values is less than a threshold number and can be updated based on the indicator value. The performance in the second time period can be determined based on the indicator value and the received indicator values in response to determining that the updated number of the received indicator values reaches the threshold number. Thus, the performance of the storage device can be quickly and accurately determined, and the consumption of computing resources is reduced.

Abstract: A data processing method includes receiving a message related to performance of a storage device, the message including an indicator value regarding the performance in a first time period, and a timestamp associated with the first time period. A status record of the storage device, including the number of received indicator values in a second time period including the first time period, is determined based on the timestamp, wherein the number of the received indicator values is less than a threshold number and can be updated based on the indicator value. The performance in the second time period can be determined based on the indicator value and the received indicator values in response to determining that the updated number of the received indicator values reaches the threshold number. Thus, the performance of the storage device can be quickly and accurately determined, and the consumption of computing resources is reduced.

Abstract: A method for determining fluids in a formation. The method includes obtaining open hole measurements for a borehole in the formation; identifying points in the borehole from which to obtain pressure measurements using the open hole measurements; obtaining pressure measurements at the identified points in the borehole; applying an excess pressure technique to the pressure measurements to identify a plurality of pressure compartments in the borehole; characterizing fluid in each of the plurality of compartments; and developing a drilling plan based on characterization of fluids in each of the plurality of compartments.

Abstract: A method for determining fluids in a formation. The method includes obtaining open hole measurements for a borehole in the formation; identifying points in the borehole from which to obtain pressure measurements using the open hole measurements; obtaining pressure measurements at the identified points in the borehole; applying an excess pressure technique to the pressure measurements to identify a plurality of pressure compartments in the borehole; characterizing fluid in each of the plurality of compartments; and developing a drilling plan based on characterization of fluids in each of the plurality of compartments.