Patents by Inventor Beilei Wang
Beilei Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10350210Abstract: The present application provides a compound of formula I, which is a EGFR and ALK dual inhibitor and can be used alone or in combination with other therapeutic agents to treat diseases such as non-small cell lung cancer. The compounds of the present application are useful in the treatment of diseases carrying the EGFR wild-type gene, or carrying the EGFR T790M mutant gene and/or the EGFR L858R mutant gene and/or the EGFR delE746_A750 mutant gene, or in the treatment of diseases carrying the ALK wild-type gene, ALK F1174L mutant gene and/or ALK F1196M gene and/or EML4-ALK mutant gene and/or NPM-ALK mutant gene, and can be used in the first-line treatment of anaplastic lymphoma kinase (ALK) positive late-stage non-small cell Lung cancer.Type: GrantFiled: December 15, 2016Date of Patent: July 16, 2019Assignee: PRECEDO PHARMACEUTICALS CO., LTDInventors: Jing Liu, Qingsong Liu, Taoshan Jiang, Aoli Wang, Jiaxin Wu, Hong Wu, Ziping Qi, Yongfei Chen, Fengming Zou, Wenchao Wang, Zheng Zhao, Li Wang, Beilei Wang
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Patent number: 10266535Abstract: Provided in the present invention is a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. Also provided in the present invention are a pharmaceutical composition comprising a compound of formula (I) and a use and method for preventing or treating cell proliferative conditions and/or FLT3-related conditions, in particular for conditions responding to the inhibition of FLT3 kinase (especially FLT3/ITD mutant kinases).Type: GrantFiled: August 7, 2015Date of Patent: April 23, 2019Assignees: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES, HEFEI COSOURCE PHARMACEUTICAL CO., LTD.Inventors: Jing Liu, Qingsong Liu, Xixiang Li, Aoli Wang, Hong Wu, Cheng Chen, Wenchao Wang, Chen Hu, Zheng Zhao, Jiaxin Wu, Juan Liu, Kailin Yu, Wei Wang, Li Wang, Beilei Wang
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Publication number: 20190084960Abstract: The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound itself in the present invention or in combination with at least one therapeutic agent can be used for preventing or treating diseases, disorders or symptoms caused by the adjustment of the activity of tyrosine kinase C-KIT, or affected by the activity of the tyrosine kinase C-KIT or involving in the activity of the tyrosine kinase C-KIT, especially cancers or other cell proliferation diseases.Type: ApplicationFiled: March 28, 2017Publication date: March 21, 2019Applicants: PRECEDO PHARMACEUTICALS CO., LTD, HEFEI GRACEVO BIO-MEDICINE CO., LTDInventors: Qingsong LIU, Jing LIU, Qiang WANG, Beilei WANG, Feiyang LIU, Shuang QI, Ziping QI, Fengming ZOU, Cheng CHEN, Wenchao WANG, Chen HU, Xiaochuan LIU, Wei WANG, Aoli WANG, Li WANG, Zhenquan HU, Tao REN
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Publication number: 20190040013Abstract: The present invention provides an inhibitor of Bruton's tyrosine kinase, which is a compound of formula (I), or its pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method for inhibiting the activity of tyrosine kinase activity or for treating a disease, disorder, or condition, which would benefit from the inhibition of Bruton's tyrosine kinase(s), by using the Bruton's tyrosine kinase inhibitor, as well application of the Bruton's tyrosine kinase inhibitor for the same.Type: ApplicationFiled: December 22, 2016Publication date: February 7, 2019Applicant: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCESInventors: Jing LIU, Qingsong LIU, Qianmao LIANG, Yongfei CHEN, Cheng CHEN, Aoli WANG, Hong WU, Kailin YU, Wei WANG, Chen HU, Wenchao WANG, Shuang QI, Beilei WANG, Li WANG
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Publication number: 20190010159Abstract: The present application provides a compound of Formula (I) as an inhibitor against wild-type EGFR and/or mutant EGFR, which may be used for treating human non-small cell lung cancer individually or in combination with other therapeutic agent(s). The compound of Formula (I) of the present application may be used for treating patients of drug-resistant human non-small cell lung cancer harboring wild-type EGFR and/or EGFR T790M mutation and/or EGFR L858R mutation and/or EGFR delE746_A750 mutation.Type: ApplicationFiled: December 27, 2016Publication date: January 10, 2019Applicant: PRECEDO PHARMACEUTICALS CO., LTDInventors: Qingsong LIU, Jing LIU, Xixiang LI, Aoli WANG, Hong WU, Kailin YU, Chen HU, Wenchao WANG, Cheng CHEN, Fengming ZOU, Ziping QI, Li WANG, Beilei WANG
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Publication number: 20180369242Abstract: The present application provides a compound of formula I, which is a EGFR and ALK dual inhibitor and can be used alone or in combination with other therapeutic agents to treat diseases such as non-small cell lung cancer. The compounds of the present application are useful in the treatment of diseases carrying the EGFR wild-type gene, or carrying the EGFR T790M mutant gene and/or the EGFR L858R mutant gene and/or the EGFR delE746_A750 mutant gene, or in the treatment of diseases carrying the ALK wild-type gene, ALK F1174L mutant gene and/or ALK F1196M gene and/or EML4-ALK mutant gene and/or NPM-ALK mutant gene, and can be used in the first-line treatment of anaplastic lymphoma kinase (ALK) positive late-stage non-small cell Lung cancer.Type: ApplicationFiled: December 15, 2016Publication date: December 27, 2018Applicant: PRECEDO PHARMACEUTICALS CO., LTDInventors: Jing LIU, Qingsong LIU, Taoshan JIANG, Aoli WANG, Jiaxin WU, Hong WU, Ziping QI, Yongfei CHEN, Fengming ZOU, Wenchao WANG, Zheng ZHAO, Li WANG, Beilei WANG
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Patent number: 10144845Abstract: A cardanol modified epoxy polyol may be used for forming a polyurethane resin system for use in applications such as coatings and composites formed by filament winding. The polyurethane resin system includes an isocyanate-reactive component that has a first cardanol component and the cardanol-modified epoxy polyol, and includes an isocyanate component that includes at least one polyisocyanate. The cardanol-modified epoxy polyol is a reaction product of an epoxy component and an epoxy-reactive component at a ratio of epoxy groups to epoxy reactive groups from 1:0.95 to 1:5, and the epoxy-reactive component includes a second cardanol component.Type: GrantFiled: November 27, 2013Date of Patent: December 4, 2018Assignee: Dow Global Technologies LLcInventors: Jiang Li, Yi Zhang, Wei Li, Beilei Wang, Paolo Diena
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Publication number: 20180030054Abstract: Provided in the present invention is a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. Also provided in the present invention are a pharmaceutical composition comprising a compound of formula (I) and a use and method for preventing or treating cell proliferative conditions and/or FLT3-related conditions, in particular for conditions responding to the inhibition of FLT3 kinase (especially FLT3/ITD mutant kinases).Type: ApplicationFiled: August 7, 2015Publication date: February 1, 2018Applicants: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES, HEFEI COSOURCE PHARMACEUTICAL CO., LTD.Inventors: Jing LIU, Qingsong LIU, Xixiang LI, Aoli WANG, Hong WU, Cheng CHEN, Wenchao WANG, Chen HU, Zheng ZHAO, Jiaxin WU, Juan LIU, Kailin YU, Wei WANG, Li WANG, Beilei WANG
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Patent number: 9814709Abstract: The present invention provides a Bruton's tyrosine kinase inhibitor, which is a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method and use of using the Bruton's tyrosine kinase inhibitor to inhibit the tyrosine kinase activity or treat diseases, disorders or symptoms benefiting from the inhibition of the Bruton's tyrosine kinase (Btk) activity.Type: GrantFiled: January 27, 2015Date of Patent: November 14, 2017Assignees: HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES, ANHUI NEW STAR PHARMACEUTICAL DEVELOPMENT CO., LTD.Inventors: Qingsong Liu, Jing Liu, Yongfei Chen, Hong Wu, Aoli Wang, Beilei Wang, Chen Hu, Wenchao Wang, Cheng Chen
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Publication number: 20170320999Abstract: A surfactant and a method of forming the surfactant having the formula (I) where a is an integer from 1 to 10, b is an integer from 0 to 10, R1 is —CH3 or —H, n is an integer from 0 to 20, and R2 is a moiety selected from the group consisting of (II), (III), (IV), (V), (VI), (VII) or (VIII) where m is an integer from 0 to 4. The surfactant can be used in a method for preparing a rigid polyurethane foam.Type: ApplicationFiled: December 17, 2014Publication date: November 9, 2017Applicant: Dow Global Technologies LLCInventors: Jiawen Xiong, Dachao Li, Jianxin Zhang, David Hong-fei Guo, Beilei Wang, Wei Liu
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Publication number: 20170247496Abstract: A reaction system, such as for forming a rigid polyurethane foam, includes a flame retardant polyol that is a brominated reaction product of a cardanol component, a bromine component, and an additive component. The cardanol component includes at least 80 wt % of cardanol, based on the total weight of the cardanol component, and the bromine component including at least 80 wt % of bromine, based on the total weight of the bromine component.Type: ApplicationFiled: November 5, 2014Publication date: August 31, 2017Inventors: Beilei Wang, Yi Zhang, Hongyu Chen, Renhua Fan, Min Yang
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Publication number: 20170128439Abstract: The present invention provides a Bruton's tyrosine kinase inhibitor, which is a compound represented by formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method and use of using the Bruton's tyrosine kinase inhibitor to inhibit the tyrosine kinase activity or treat diseases, disorders or symptoms benefiting from the inhibition of the Bruton's tyrosine kinase (Btk) activity.Type: ApplicationFiled: January 27, 2015Publication date: May 11, 2017Inventors: Qingsong LIU, Jing LIU, Yongfei CHEN, Hong WU, Aoli WANG, Beilei WANG, Chen HU, Wenchao WANG, Cheng CHEN
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Publication number: 20160333160Abstract: A rigid polyurethane (PU) foam having a number average cell size of no greater than 10Type: ApplicationFiled: January 23, 2014Publication date: November 17, 2016Applicants: Dow Global Technologies LLC, Rohm and Haas CompanyInventors: Luigi Bertucelli, Vanni Parenti, Dachao Li, Wei Liu, Ning Chai, Beilei Wang, Cheng Chen, Hong Fei Guo, Jing Chen, Yige Yin, Stephane Costeux, Billy G. Smith
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Publication number: 20160257848Abstract: A cardanol modified epoxy polyol may be used for forming a polyurethane resin system for use in applications such as coatings and composites formed by filament winding. The polyurethane resin system includes an isocyanate-reactive component that has a first cardanol component and the cardanol-modified epoxy polyol, and includes an isocyanate component that includes at least one polyisocyanate. The cardanol-modified epoxy polyol is a reaction product of an epoxy component and an epoxy-reactive component at a ratio of epoxy groups to epoxy reactive groups from 1:0.95 to 1:5, and the epoxy-reactive component includes a second cardanol component.Type: ApplicationFiled: November 27, 2013Publication date: September 8, 2016Applicant: Dow Global Technologies LLCInventors: Jiang Li, Yi Zhang, Wei Li, Beilei Wang, Paolo Diena
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Patent number: 9328859Abstract: This invention relates to rigid isocyanate-based polymer foam and composites thereof comprising a carbon black component comprising at least 50 weight percent of a fluorinated carbon black. Said foam having improved thermal properties, specifically, rigid polyurethane and/or polyisocyanurate foams for use in said insulation applications.Type: GrantFiled: July 26, 2011Date of Patent: May 3, 2016Assignee: Dow Global Technologies LLCInventors: Yige Yin, Jing G. Chen, Beilei Wang, Li Ye, Vanni Parenti
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Patent number: 9267035Abstract: This invention relates to rigid isocyanate-based polymer foam comprising a carbon black component comprising at least 50 weight percent of a fluorinated carbon black. Said foam having improved thermal properties, specifically, rigid polyurethane and/or polyisocyanurate foams for use in insulation applications.Type: GrantFiled: June 21, 2011Date of Patent: February 23, 2016Assignee: Dow Global Technologies LLCInventors: Yige Yin, Jing G. Chen, Beilei Wang, Li Ye, Vanni Parenti, Li Mu, Yahong Zhang
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Publication number: 20140151593Abstract: This invention relates to rigid isocyanate-based polymer foam and composites thereof comprising a carbon black component comprising at least 50 weight percent of a fluorinated carbon black. Said foam having improved thermal properties, specifically, rigid polyurethane and/or polyisocyanurate foams for use in said insulation applications.Type: ApplicationFiled: July 26, 2011Publication date: June 5, 2014Applicant: Dow Global Technologies, LLCInventors: Yige Yin, Jing G. Chen, Beilei Wang, Li Ye, Vanni Parenti
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Publication number: 20140117270Abstract: This invention relates to rigid isocyanate-based polymer foam comprising a carbon black component comprising at least 50 weight percent of a fluorinated carbon black. Said foam having improved thermal properties, specifically, rigid polyurethane and/or polyisocyanurate foams for use in insulation applications.Type: ApplicationFiled: June 21, 2011Publication date: May 1, 2014Applicant: Dow Global Technologies LLCInventors: Yige Yin, Jing G. Chen, Beilei Wang, Li Ye, Vanni Parenti, Li Mu, Yahong Zhang
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Publication number: 20100111263Abstract: Systems, methods and apparatus are provided through which in some implementations a portable digital X-ray detector includes a modular handle that is removeable from a housing of the detector, the modular handle includes component(s) that perform functions that are specific to a number of portable digital X-ray detectors, such as data communication with external devices and/or power conditioning, and the housing of the detector includes the pixel array and component(s) that perform functions that are common to the pixel array. In some implementations, the modular handle includes an interface to the housing to support data communications and/or power supply with the component(s) in the housing and the housing also includes an interface that operably couples to the modular handle.Type: ApplicationFiled: October 30, 2008Publication date: May 6, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: John Lamberty, Beilei Wang, James Zhengshe Liu
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Patent number: D741737Type: GrantFiled: July 2, 2014Date of Patent: October 27, 2015Assignee: Micro Motion, Inc.Inventors: Xiang Feng, Muyuan Liu, Yang Ye, Beilei Wang, Clinton R Griffin