Abstract: A core collector is shaped as a crescent in cross-section and has lateral sides formed into axially extending rows of axially spaced teeth. The arc angle of the crescent shape is sufficient to keep the core collector radially centered in a cannula by having the crescent's lateral sides bear against the inside of the cannula. The set of a core collector and cannula can be used in a known biopsy system to replace the known cannula and core collector of can be used in a new core biopsy instrument.

Abstract: A biopsy needle set that includes an outer cannula and a core collector that slides therein and includes a cradle that has a trough-shaped open space formed between a keel and two rows of teeth rising from lateral ends of the keel.

Abstract: A core collector is shaped as a crescent in cross-section and has lateral sides formed into axially extending rows of axially spaced teeth. The arc angle of the crescent shape is sufficient to keep the core collector radially centered in a cannula by having the crescent's lateral sides bear against the inside of the cannula. The set of a core collector and cannula can be used in a known biopsy system to replace the known cannula and core collector of can be used in a new core biopsy instrument.

Abstract: A core biopsy instrument for taking samples of tissue such as prostate tissue comprises a handle configured to releasably receive a cartridge that holds a core collector. In use, after loading a cartridge in the handle, a spring drives the core collector into target tissue and shortly thereafter, in less than a second, a spring drives a cannula over the core collector to cut tissue in a trough thereof from surrounding tissue. The core collector is withdrawn proximally to its initial position in the cartridge and the cartridge is removed from the handle. The cartridge, with the core collector and the tissue sample therein is treated as needed for sending as a unit to a laboratory, thus preserving the orientation and completeness of the tissue sample therein.

Abstract: A method of treating symptoms of benign prostatic hypertrophy and a method of treating lower urinary tract symptoms, are disclosed. The method includes administering to a mammal about 1 to about 20 milligrams of an agent that inhibits cyclic guanosine 3,5-monophosphate specific phosphodiesterase type 5.