Abstract: The present invention relates to a method for the recombinant production of a serine protease comprising (a) culturing a host cell comprising one or more vectors, wherein the one or more vectors encode in expressible form the serine protease and a proteinaceous inhibitor of the serine protease, wherein the proteinaceous inhibitor of the serine protease is heterologous with respect to the serine protease, under conditions wherein the serine protease and the proteinaceous inhibitor of the serine protease are expressed; or (a?) culturing a host cell the genome of which encodes in expressible form the serine protease and a proteinaceous inhibitor of the serine protease, wherein the proteinaceous inhibitor of the serine protease is heterologous with respect to the serine protease, and wherein the coding sequences of the serine protease and/or the proteinaceous inhibitor have been introduced into the host cell genome by applying a CRISPR technology, under conditions wherein the serine protease and the proteinaceous

Abstract: The present invention relates to a method for the recombinant production of a serine protease comprising (a) culturing a host cell comprising one or more vectors, wherein the one or more vectors encode in expressible form the serine protease and a proteinaceous inhibitor of the serine protease, wherein the proteinaceous inhibitor of the serine protease is heterologous with respect to the serine protease, under conditions wherein the serine protease and the proteinaceous inhibitor of the serine protease are expressed; or (a?) culturing a host cell the genome of which encodes in expressible form the serine protease and a proteinaceous inhibitor of the serine protease, wherein the proteinaceous inhibitor of the serine protease is heterologous with respect to the serine protease, and wherein the coding sequences of the serine protease and/or the proteinaceous inhibitor have been introduced into the host cell genome by applying a CRISPR technology, under conditions wherein the serine protease and the proteinaceous

Abstract: The invention refers to a cell free assay for determining the activity of a Na+/Ca2+ exchanger (NCX) protein by means of a cell free electrophysiological sensor chip, a kit of parts comprising the sensor chip with a NCX protein as well as the manufacturing and use of the kit of parts.

Abstract: The present invention refers to a method for determining the activity of the organic cation transporter (OCT), a method for determining the activity of or identifying a chemical compound that modulates the activity of OCT with the help of a cell free electrophysiological sensor chip containing a solid-supported sensor electrode and a lipid layer containing the OCT located in the immediate spatial vicinity to the sensor electrode, whereas the sensor electrode is electrically insulated relative to the solutions used and to the lipid layer, as well as to the sensor chip itself and a kit containing same.

Abstract: The present invention relates to a type PepT1 protein assay and in particular a process for identifying a substrate and/or a modulator of the PepT1 protein.

Abstract: The invention refers to a cell free assay for determining the activity of a Na+/Ca2+ exchanger (NCX) protein by means of a cell free electrophysiological sensor chip, a kit of parts comprising the sensor chip with a NCX protein as well as the manufacturing and use of the kit of parts.

Abstract: The invention relates to a biocompatible sensor electrode arrangement and to a process for its manufacture, at least one carrier substrate area (22), at least one intermediate substrate area (26) on the surface area (22a) of the carrier substrate area (22) and a biomaterial area (24) on the top side surface area (26a) of the intermediate substrate area (26) being provided. The biomaterial area (24) consists of at least one biologically compatible material component. The carrier substrate area (22) with the intermediate substrate area (26) is formed in the form or the manner of a wafer element or a printed circuit, as photolithographically processed structure, as structure bonded on or laminated on and/or as structure processed by printing, in particular on the carrier substrate (22) in each case.

Abstract: A biosensor arrangement and a method for producing a biosensor arrangement. The biosensor arrangement comprises at least one electrode substrate with a surface which forms an electrode of the biosensor arrangement. At least one biomaterial area is formed which is provided in and/or on the surface of the electrode substrate. The electrode substrate is formed with or of a synthetic material or with or of a polymer material, which in turn is electrically conductive.

Abstract: Inhibitors of the cellular sodium-hydrogen exchanger are employed for preparing a medicament for preventing age-related functional disorders and dysfuntional changes of organs of the body and for preventing age-related diorders and for prolonging life while maintaining an improved quality of life.